Results 211 to 220 of about 11,104 (231)

Stereoselective Approaches to β-Linked 2-Deoxy Sugars. [PDF]

Molecules
Bennett CS.
europepmc   +1 more source

Digoxin Attenuates Ocular Hypertension and Protects Trabecular Meshwork Cells via Ferroptosis Inhibition. [PDF]

Invest Ophthalmol Vis Sci
Zhou X, Li Z, Zhang X, Xu J, Wu P, Zhu W, Ji D, Duan X.   +7 more
europepmc   +1 more source

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Digitoxin inhibits HeLa cell growth through the induction of G2/M cell cycle arrest and apoptosis in vitro and in vivo.

International Journal of Oncology, 2020
Cervical cancer is the fourth most common gynecological malignancy affecting the health of women worldwide and the second most common cause of cancer‑related mortality among women in developing regions. Thus, the development of effective chemotherapeutic
Hua Gan, Ming Qi, C. Chan, P. Leung, Geni Ye, Yuhe Lei, A. Liu, Feifei Xue, Dongdong Liu, W. Ye, Dongmei Zhang, Lijuan Deng, Jiaxu Chen   +12 more
semanticscholar   +1 more source

Successful Treatment of Severe Digitoxin Intoxication with CytoSorb® Hemoadsorption

Blood Purification, 2020
While several intoxications can be successfully treated with specific antidotes, intoxications with the steroid glycoside digitoxin still represent a major challenge.
T. Breuer, D. Quast, Stephan Wiciok, A. Labedi, G. Ellrichmann   +4 more
semanticscholar   +1 more source

Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction.

New England Journal of Medicine
BACKGROUND The therapeutic efficacy of the cardiac glycoside digitoxin in patients with heart failure and reduced ejection fraction is not established. METHODS In this international, double-blind, placebo-controlled trial, we randomly assigned patients
U. Bavendiek, A. Grosshennig, Johannes Schwab, Dominik Berliner, Andreas Rieth, L. Maier, Thomas Gaspar, N. Thomas, Xiaofei Liu, S. Schallhorn, Eleonora Angelini, Samira Soltani, Fabian Rathje, Mircea‐Andrei Sandu, Welf Geller, Rainer Hambrecht, Marija Zdravkovic, S. Philipp, Dragana Kosevic, G. Nickenig, Daniel Scheiber, Sebastian Winkler, P. Becher, P. Lurz, Martin Hülsmann, Sören Wiesner, Christoph Schröder, Barbara Neuhaus, Anika Seltmann, Heiko von der Leyen, C. Veltmann, Stefan Störk, Michael Böhm, Armin Koch, J. Bauersachs   +34 more
semanticscholar   +1 more source

Digitoxin Attenuates Heart Failure, Reduces Myocardial Hypertrophy, and Preserves the Calcium-Binding Proteins in Infarcted Rats

Journal of Cardiovascular Pharmacology and Therapeutics, 2019
We previously showed that digitoxin prolongs the survival of rats with heart failure due to myocardial infarction (MI). In this study, we evaluated the effect of digitoxin on myocardial structure, ventricular function, and proteins involved in calcium ...
C. Picollo, Alexandra A. Santos, E. Antonio, J. A. Silva, D. Bocalini, A. Serra, S. Ihara, P. Tucci   +7 more
semanticscholar   +1 more source

Digitoxin Suppresses Store Operated Calcium Entry by Modulating Phosphorylation and the Pore Region of Orai1.

Current molecular medicine, 2019
BACKGROUND Store-operated calcium entry (SOCE), primarily mediated by Orai1 and stromal interaction molecule 1 (STIM1), is a major Ca2+ influx pathway that has been linked to human diseases including myopathy, epilepsy, immunodeficiency, and cancer ...
Lijuan Zhou, Xiangxiang Chi, Yaping Zhu, Tian Zhang, Jindou Liu, G. Ma, Lian He, Shuce Zhang, Ping Gao, Yubin Zhou, Jin Liu, Youjun Wang   +11 more
semanticscholar   +1 more source