Results 31 to 40 of about 10,900 (273)
International Journal of Molecular Sciences, 2022 Digitoxin has repeatedly shown to have negative effects on cancer cell viability; however, the actual mechanism is still unknown. In this study, we investigated the effects of digitoxin (1–100 nM) in four pancreatic cancer cell lines, BxPC-3, CFPAC-1 ...
H. Lindholm +2 more
semanticscholar +1 more source
Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses
Molecules, 2021 Drug repositioning is a successful approach in medicinal research. It significantly simplifies the long-term process of clinical drug evaluation, since the drug being tested has already been approved for another condition.
Jan Škubník +3 more
doaj +1 more source
Quo vadis Cardiac Glycoside Research?
Toxins, 2021 Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček +3 more
doaj +1 more source
Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation
Molecules, 2021 Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential process for mammalian cell survival. An enzyme responsible for this process, sodium-potassium ATPase (NKA), has been currently extensively studied as a potential ...
Jiří Bejček +3 more
doaj +1 more source
Classical Drug Digitoxin Inhibits Influenza Cytokine Storm, With Implications for Covid-19 Therapy
In Vivo, 2020 Background/Aim: Influenza viruses, corona viruses and related pneumotropic viruses cause sickness and death partly by inducing cytokine storm, a hyper-proinflammatory host response by immune cells and cytokines in the host airway.
B. Pollard, Jorge C. BLANCOl, J. Pollard
semanticscholar +1 more source
Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics [PDF]
, 2009 We consider the problem of constructing optimal designs for population pharmacokinetics which use random effect models. It is common practice in the design of experiments in such studies to assume uncorrelated errors for each subject.
Dette, Holger +2 more
core +6 more sources
British Journal of Clinical Pharmacology, 1982 1 Nine healthy volunteers received single 1 mg intravenous doses of digitoxin, following which serum digitoxin concentrations were measured at multiple points in time over the next 14 days. 2 Mean kinetic variables for digitoxin were: volume of distribution, 0.76 l/kg; elimination half‐life, 8 days; total clearance, 0.049 ml min‐1 kg‐1.
J Hartlapp +3 more
openaire +3 more sources
Accidental digitoxin intoxication: an interplay between laboratory and clinical medicine [PDF]
Biochemia Medica, 2012 Introduction: Two Italian adults arrived at the Emergency Department referring diarrhea, nausea and vomiting for 4 days; weakness, fatigue and visual hallucinations were also complained of. Patients reported the ingestion of some leaves of a plant, which
Luigi Mario Castello +7 more
openalex +2 more sources
Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]
, 2015 PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David +13 more
core +2 more sources
Oncology Report, 2015 Despite significant advances in the understanding of lung cancer biology, the prognosis of cancer patients remains poor. Part of the failure of anticancer therapy is due to intratumoral heterogeneity in these patients that limits the efficacy of single ...
Juan Sebastián Yakisich +7 more
openalex +3 more sources