Of mixed vegetables and cardiac arrhythmias - Digitalis purpurea confused with Borago officinalis: A case series of accidental digitoxin intoxications. [PDF]
J Cardiol Cases, 2023 Iraci F +3 more
europepmc +3 more sources
The in vivo effect of digitoxin on rat heart phosphatides*
Journal of Lipid Research, 1961 Digitoxin was shown to increase the specific activity of heart ventricle phosphatides in rats receiving simultaneously radioactive orthophosphate and digitoxin as compared to control rats not receiving digitoxin.
G.V. Marinetti, K. Temple, Elmer Stotz
doaj +1 more source
Digitoxin medication and cancer; case control and internal dose-response studies
BMC Cancer, 2001 Background Digitoxin induces apoptosis in different human malignant cell lines in vitro. In this paper we investigated if patients taking digitoxin for cardiac disease have a different cancer incidence compared to the general population. Methods Computer
Spigset Olav +3 more
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Development of CPA-Catalyzed β-Selective Reductive Amination of Cardenolides for the Synthesis and Biological Evaluation of Hydrolytically Stable Analogs. [PDF]
ChemistryWe describe a new method to produce hydrolytically stable cardiotonic steroids using a CPA‐controlled diastereoselective reductive amination of cardenolide aglycones. The oleandrin and digitoxigenin analogs exhibited promising activity against various cancer cell lines in the NCI‐60 screen.
Perry N +3 more
europepmc +2 more sources
Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics [PDF]
, 2009 We consider the problem of constructing optimal designs for population pharmacokinetics which use random effect models. It is common practice in the design of experiments in such studies to assume uncorrelated errors for each subject.
Dette, Holger +2 more
core +6 more sources
Structure-based virtual screening to predict Loxosceles spider venom natural inhibitors
Digital Chinese Medicine, 2023 Objective: Loxosceles spider bite accidents are rising in wide areas of the world which necessitates the exploration of natural inhibitors to inhibit the most significant enzymes, namely sphingomyelinase D (Smase D) and hyaluronidase.
Haitham Ahmed Al-Madhagi
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Basic Research in Cardiology, 2020 Desmosomal proteins are components of the intercalated disc and mediate cardiac myocyte adhesion. Enhancement of cardiac myocyte cohesion, referred to as “positive adhesiotropy”, was demonstrated to be a function of sympathetic signaling and to be ...
C. Schinner +9 more
semanticscholar +1 more source
Molecules, 2022 The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding free ...
Wesam S. Qayed +2 more
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Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies [PDF]
, 2017 Cardiac glycosides are phytoestrogens and have been linked to the risk of estrogen sensitive cancers such as uterus cancer. However, the association between use of cardiac glycosides and risk of breast cancer remains unclear.
Ahern +26 more
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Scientific Reports, 2021 To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells.
Hung Caohuy +8 more
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