Results 31 to 40 of about 10,909 (272)
A multicentre registry of hospitalized patients with acute and chronic heart failure: Study design of the H<sup>2</sup>-registry. [PDF]
ESC Heart FailThe H2‐Registry: overview, first results and outlook. Abstract Aims Heart failure (HF) is a highly prevalent condition affecting 1–3% of the adult population in Europe. Despite landmark improvements in HF care over the last two decades, hospitalization and mortality rates remain relatively high.
Leiner J +15 more
europepmc +2 more sources
Quo vadis Cardiac Glycoside Research?
Toxins, 2021 Cardiac glycosides (CGs), toxins well-known for numerous human and cattle poisoning, are natural compounds, the biosynthesis of which occurs in various plants and animals as a self-protective mechanism to prevent grazing and predation.
Jiří Bejček +3 more
doaj +1 more source
British Journal of Clinical Pharmacology, 1982 1 Nine healthy volunteers received single 1 mg intravenous doses of digitoxin, following which serum digitoxin concentrations were measured at multiple points in time over the next 14 days. 2 Mean kinetic variables for digitoxin were: volume of distribution, 0.76 l/kg; elimination half‐life, 8 days; total clearance, 0.049 ml min‐1 kg‐1.
J Hartlapp +3 more
openaire +3 more sources
Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation
Molecules, 2021 Maintenance of Na+ and K+ gradients across the cell plasma membrane is an essential process for mammalian cell survival. An enzyme responsible for this process, sodium-potassium ATPase (NKA), has been currently extensively studied as a potential ...
Jiří Bejček +3 more
doaj +1 more source
Classical Drug Digitoxin Inhibits Influenza Cytokine Storm, With Implications for Covid-19 Therapy
In Vivo, 2020 Background/Aim: Influenza viruses, corona viruses and related pneumotropic viruses cause sickness and death partly by inducing cytokine storm, a hyper-proinflammatory host response by immune cells and cytokines in the host airway.
B. Pollard, Jorge C. BLANCOl, J. Pollard
semanticscholar +1 more source
Simultaneous Treatment of Two Severe Acute Intoxication and Acute Kidney Injury. [PDF]
Semin DialABSTRACT Extracorporeal therapies could be required for treatment of life‐threatening severe acute intoxication. We present the case of an 82‐year‐old patient admitted to our Nephrology Unit because of metformin‐associated lactic acidosis (MALA) and acute kidney injury (AKI stage III AKIN criteria).
Zappulo F +7 more
europepmc +2 more sources
Accidental digitoxin intoxication: an interplay between laboratory and clinical medicine [PDF]
Biochemia Medica, 2012 Introduction: Two Italian adults arrived at the Emergency Department referring diarrhea, nausea and vomiting for 4 days; weakness, fatigue and visual hallucinations were also complained of. Patients reported the ingestion of some leaves of a plant, which
Luigi Mario Castello +7 more
openalex +2 more sources
Oncology Letters, 2020 Hepatocellular carcinoma (HCC) remains a challenge in the medical field due to its high malignancy and mortality rates particularly for HCC, which has developed multidrug resistance.
Yuhe Lei +15 more
semanticscholar +1 more source
Structure-based virtual screening to predict Loxosceles spider venom natural inhibitors
Digital Chinese Medicine, 2023 Objective: Loxosceles spider bite accidents are rising in wide areas of the world which necessitates the exploration of natural inhibitors to inhibit the most significant enzymes, namely sphingomyelinase D (Smase D) and hyaluronidase.
Haitham Ahmed Al-Madhagi
doaj +1 more source
Optimal designs for random effect models with correlated errors with applications in population pharmacokinetics [PDF]
, 2009 We consider the problem of constructing optimal designs for population pharmacokinetics which use random effect models. It is common practice in the design of experiments in such studies to assume uncorrelated errors for each subject.
Dette, Holger +2 more
core +6 more sources