Results 41 to 50 of about 10,900 (273)
Oncology Letters, 2020 Hepatocellular carcinoma (HCC) remains a challenge in the medical field due to its high malignancy and mortality rates particularly for HCC, which has developed multidrug resistance.
Yuhe Lei +15 more
semanticscholar +1 more source
Molecules, 2022 The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding free ...
Wesam S. Qayed +2 more
doaj +1 more source
Severity of the cardiac impairment determines whether digitalis prolongs or reduces survival of rats with heart failure due to myocardial infarction [PDF]
, 2013 Background: the aim of the present study was to evaluate if the influence of digitalis on survival depends on the severity of cardiac dysfunction in heart failure (HF).Methods and results: Doppler echocardiogram (DE) parameters were analyzed in 84 Wistar
Antonio, Ednei Luiz +4 more
core +2 more sources
Scientific Reports, 2021 To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells.
Hung Caohuy +8 more
doaj +1 more source
Effects of cardiovascular drugs on ATPase activity of P-glycoprotein in plasma membranes and in purified reconstituted form [PDF]
, 1998 Drug interactions with P-glycoprotein (Pgp) were quantitatively assessed using ATPase assay. Two experimental systems were used, (i) plasma membranes isolated from a multidrug-resistant cell line, which contained 30% Pgp as fraction of total membrane ...
Al-Shawi +49 more
core +1 more source
European Journal of Heart Failure, 2019 Despite recent advances in the treatment of chronic heart failure (HF), mortality and hospitalizations still remain high. Additional therapies to improve mortality and morbidity are urgently needed. The efficacy of cardiac glycosides – although regularly
U. Bavendiek +38 more
semanticscholar +1 more source
Intracellular Distribution of Digitoxin.
Experimental Biology and Medicine, 1953 SummaryThe hearts and livers of animals given intravenous digi toxin were homogenized and separated by centrifugation into nuclear, mitochondrial and homogeneous supernatant fractions. More than 85% of the digi toxin was found in the supernatant fractions of both heart and liver, while the mitochondria of the organs contained 3 and 0.1%.
Shirley St. George +2 more
openaire +3 more sources