Results 41 to 50 of about 10,909 (272)

Digitoxin and its synthetic analog MonoD have potent antiproliferative effects on lung cancer cells and potentiate the effects of hydroxyurea and paclitaxel

Oncology Report, 2015
Despite significant advances in the understanding of lung cancer biology, the prognosis of cancer patients remains poor. Part of the failure of anticancer therapy is due to intratumoral heterogeneity in these patients that limits the efficacy of single ...
Juan Sebastián Yakisich, Neelam Azad, Rajkumar Venkatadri, Yogesh Kulkarni, Clayton Wright, Vivek Kaushik, George A. O’Doherty, Anand Krishnan V. Iyer   +7 more
openalex   +3 more sources

In Silico Study towards Repositioning of FDA-Approved Drug Candidates for Anticoronaviral Therapy: Molecular Docking, Molecular Dynamics and Binding Free Energy Calculations

Molecules, 2022
The SARS-CoV-2 targets were evaluated for a set of FDA-approved drugs using a combination of drug repositioning and rigorous computational modeling methodologies such as molecular docking and molecular dynamics (MD) simulations followed by binding free ...
Wesam S. Qayed, Rafaela S. Ferreira, José Rogério A. Silva   +2 more
doaj   +1 more source

DIGITOXIN [PDF]

The American Journal of the Medical Sciences, 1895
n ...
openaire   +2 more sources

Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells

Scientific Reports, 2021
To initiate SARS-CoV-2 infection, the Receptor Binding Domain (RBD) on the viral spike protein must first bind to the host receptor ACE2 protein on pulmonary and other ACE2-expressing cells.
Hung Caohuy, Ofer Eidelman, Tinghua Chen, Shufeng Liu, Qingfeng Yang, Alakesh Bera, Nathan I. Walton, Tony T. Wang, Harvey B. Pollard   +8 more
doaj   +1 more source

A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells [PDF]

, 2013
Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium oleander has been used in traditional medicine for treating several disorders including cancer, and extracts from the leaves of this ...
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, López Lázaro, Miguel, Mateos Cordero, Santiago, Orta Vázquez, Manuel Luis   +4 more
core   +2 more sources

Circular dichroism spectroscopic detection of ligand binding induced subdomain IB specific structural adjustment of human serum albumin [PDF]

, 2013
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein.
Beaven G. H., Bertucci C., Bertucci C., Bhattacharya A. A., Brock A., Buttar D., Carter D. C., Curry S., Curry S., Datta P., Dockal M., Farruggia B., Fehske K. J., Fehske K. J., Fehske K. J., Ferenc Zsila, Ghuman J., Ishida S., Koide M., Kragh-Hansen U., Krenzel E. S., Plager J. E., Ryan A. J., Ryan A. J., Sengupta A., Shi D., Simard J. R., Sjöholm I., Strickland E. H., Sudlow G., Sudlow G., Takikawa H., Wanwimolruk S., Zhu L., Zsila F., Zsila F., Zunszain P. A., Zunszain P. A.   +37 more
core   +1 more source

Rationale and design of the DIGIT‐HF trial (DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure): a randomized, double‐blind, placebo‐controlled study

European Journal of Heart Failure, 2019
Despite recent advances in the treatment of chronic heart failure (HF), mortality and hospitalizations still remain high. Additional therapies to improve mortality and morbidity are urgently needed. The efficacy of cardiac glycosides – although regularly

semanticscholar   +1 more source

Consequences of toxic secondary compounds in nectar for mutualist bees and antagonist butterflies [PDF]

, 2016
Attraction of mutualists and defense against antagonists are critical challenges for most organisms and can be especially acute for plants with pollinating and non?pollinating flower visitors.
Agrawal, Anurag A., Jones, Patricia L.
core   +2 more sources

Über Digitoxin [PDF]

Berichte der deutschen chemischen Gesellschaft, 1907
n ...
openaire   +2 more sources

Intracellular Distribution of Digitoxin.

Experimental Biology and Medicine, 1953
SummaryThe hearts and livers of animals given intravenous digi toxin were homogenized and separated by centrifugation into nuclear, mitochondrial and homogeneous supernatant fractions. More than 85% of the digi toxin was found in the supernatant fractions of both heart and liver, while the mitochondria of the organs contained 3 and 0.1%.
Shirley St. George, Meyer Friedman, Tadashi Ishida   +2 more
openaire   +3 more sources