Results 41 to 50 of about 2,840 (150)

Investigation of Relationship Between Chemical Stress Factors and Certain Metabolites Including Cardenolides in Callus Cultures of Endemic Turkish Digitalis L. Species

International Journal of Secondary Metabolite, 2017
The aim of the present research is to obtain relationship between different stress treatments [Cu (copper) and Hg (mercury)] and content of cardiac glycosides (digoxigenin, gitoxigenin, lanatoside C, digoxin and digitoxin) as secondary metabolites of ...
Gunce Sahin, Sandeep Kumar Verma, Ekrem Gurel   +2 more
doaj   +1 more source

In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Parasite, 2021
Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required.
Freitas Camila S., Lage Daniela P., Oliveira-da-Silva João A., Costa Rafaella R., Mendonça Débora V.C., Martins Vívian T., Reis Thiago A.R., Antinarelli Luciana M.R., Machado Amanda S., Tavares Grasiele S.V., Ramos Fernanda F., Brito Rory C.F., Ludolf Fernanda, Chávez-Fumagalli Miguel A., Roatt Bruno M., Ramos Gabriela S., Munkert Jennifer, Ottoni Flaviano M., Campana Priscilla R.V., Duarte Mariana C., Gonçalves Denise U., Coimbra Elaine S., Braga Fernão C., Pádua Rodrigo M., Coelho Eduardo A.F.   +24 more
doaj   +1 more source

Tetra‐Cationic Pyridyl‐Porphyrins With Peripheral Rhenium(I) Complexes: Photophysics, Photobiological, and BSA‐Binding Properties

European Journal of Inorganic Chemistry, Volume 29, Issue 1, January 1, 2026.
Synthesis, photophysical and electrochemical characterization of tetra‐cationic porphyrins containing Re(I) complexes and BSA‐binding properties In this article, isomeric tetra‐cationic porphyrins with rhenium(I)‐carbonyl‐phenanthroline complexes at the peripheral N‐pyridyl positions 3ReP and 4ReP were evaluated for structural characterization ...
Rafaela C. Copello, André S. Polo, Rafael de Q. Garcia, Leonardo De Boni, Luiz Antônio Sodré Costa, Henrique F. V. Victória, Klaus Krambrock, Otávio A. Chaves, Bernardo A. Iglesias   +8 more
wiley   +1 more source

Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death

Molecules, 2016
Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be ...
Qian Feng, Wa Seng Leong, Liang Liu, Wai-In Chan   +3 more
doaj   +1 more source

Combined amiodarone and digitalis therapy before heart transplantation is associated with increased post‐transplant mortality

ESC Heart Failure, 2020
Aims Amiodarone and digitalis are frequently used drugs in patients with heart failure. Both have separately been linked to reduced post‐transplant survival, but their combined impact on mortality after HTX remains uncertain.
Rasmus Rivinius, Matthias Helmschrott, Ann‐Kathrin Rahm, Fabrice F. Darche, Dierk Thomas, Tom Bruckner, Andreas O. Doesch, Philipp Ehlermann, Hugo A. Katus, Edgar Zitron   +9 more
doaj   +1 more source

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

OSWALD SCHMIEDEBERG –THE “FATHER” OF EXPERIMENTAL PHARMACOLOGY [PDF]

Research Results in Pharmacology, 2017
Biography. Oswald Schmiedeberg (1838-1921) was a son of a bailiff and a maid of honour, the eldest of the six children in the family. He was born and educated in the Russian Empire. Scientific activity. All his life he was completely devoted to science,
Mikhail Pokrovskii, Tatyana Avtina, Elena Zakharova, Yulia Belousova   +3 more
doaj   +3 more sources

Repurposing Cardiac Glycosides to Potentiate CD47 Blockade through Calreticulin‐mediated Phagocytic Effects for Lung Cancer Treatment

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Repurposing cardiac glycosides (CGs) significantly strengthens the efficacy of anti‐CD47 antibody for lung cancer treatment by boosting macrophage phagocytosis. This novel combination blocks the “don't eat me” signal and increases dual “eat‐me” signals, Fc‐FcγR and cell surface expression of calreticulin (ecto‐CRT).
Zi‐Han Ye, Wei‐Bang Yu, Mu‐Yang Huang, Yan‐Yan Chen, Le‐Le Zhang, Chung‐Hang Leung, Xiao‐Lei Zhang, Zhenghai Tang, Ting Li, Jin‐Jian Lu   +9 more
wiley   +1 more source

Production of cadiotonic glycosides in Digitalis purpurea using temporary immersion systems

Biotecnología Vegetal, 2005
Digitalis purpurea, is an example of cardiotonic drug. Digoxin and digitoxin are glycosides produced by this plant which are cardiac stimulants with a wide use in the treatment of heart problems.
Naivy Pérez-Alonso, Elio Jiménez, Dirk Wilken, André Gerth, Annett Jähn, Horst-Michael Nitzsche, Gerhard Kerns   +6 more
doaj  

Clinical Impact of Digitalis Therapy in a Large Multicenter Cohort of CRT-Recipients

Journal of Cardiovascular Development and Disease
(1) Introduction: Digitalis use in patients with severe heart failure is controversial. We assessed the effects of digitalis therapy on mortality in a large, observational study in recipients of cardiac resynchronization therapy (CRT).
Julia W. Erath, Nikolett Vigh, Balazs Muk, Carsten W. Israel, Sarah Keck, David Pilecky, Gabor Z. Duray, Mate Vamos   +7 more
doaj   +1 more source