Results 41 to 50 of about 11,104 (231)

A hydroalcoholic extract from the leaves of Nerium oleander inhibits glycolysis and induces selective killing of lung cancer cells [PDF]

, 2013
Recent evidence suggests that cardiac glycosides might be used for the treatment of cancer. The ornamental shrub Nerium oleander has been used in traditional medicine for treating several disorders including cancer, and extracts from the leaves of this ...
Burgos Morón, Estefanía, Calderón Montaño, José Manuel, López Lázaro, Miguel, Mateos Cordero, Santiago, Orta Vázquez, Manuel Luis   +4 more
core   +2 more sources

Circular dichroism spectroscopic detection of ligand binding induced subdomain IB specific structural adjustment of human serum albumin [PDF]

, 2013
This work demonstrates for the first time that binding of various compounds within subdomain IB of human serum albumin (HSA) provokes characteristic changes in the near-UV circular dichroism (CD) spectrum of the protein.
Beaven G. H., Bertucci C., Bertucci C., Bhattacharya A. A., Brock A., Buttar D., Carter D. C., Curry S., Curry S., Datta P., Dockal M., Farruggia B., Fehske K. J., Fehske K. J., Fehske K. J., Ferenc Zsila, Ghuman J., Ishida S., Koide M., Kragh-Hansen U., Krenzel E. S., Plager J. E., Ryan A. J., Ryan A. J., Sengupta A., Shi D., Simard J. R., Sjöholm I., Strickland E. H., Sudlow G., Sudlow G., Takikawa H., Wanwimolruk S., Zhu L., Zsila F., Zsila F., Zunszain P. A., Zunszain P. A.   +37 more
core   +1 more source

Consequences of toxic secondary compounds in nectar for mutualist bees and antagonist butterflies [PDF]

, 2016
Attraction of mutualists and defense against antagonists are critical challenges for most organisms and can be especially acute for plants with pollinating and non?pollinating flower visitors.
Agrawal, Anurag A., Jones, Patricia L.
core   +2 more sources

Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]

, 2015
PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David, Arana, Eloisa, Buitrago, Emiliano, Chantada, Guillermo Luis, Croxatto, Juan Oscar, del Sole, Maria Jose, Djaballah, Hakim, Francis, Jasmine, Laurent, Viviana Eunice, Mena, Hebe Agustina, Negrotto, Soledad, Schaiquevich, Paula Susana, Sgroi, Mariana, Winter, Ursula Andrea   +13 more
core   +2 more sources

Rationale and design of the DIGIT‐HF trial (DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure): a randomized, double‐blind, placebo‐controlled study

European Journal of Heart Failure, 2019
Despite recent advances in the treatment of chronic heart failure (HF), mortality and hospitalizations still remain high. Additional therapies to improve mortality and morbidity are urgently needed. The efficacy of cardiac glycosides – although regularly

semanticscholar   +1 more source

Gene therapy-emulating small molecule treatments in cystic fibrosis airway epithelial cells and patients

Respiratory Research, 2019
Background Several small molecule corrector and potentiator drugs have recently been licensed for Cystic Fibrosis (CF) therapy. However, other aspects of the disease, especially inflammation, are less effectively treated by these drugs.
Q. Yang, A. R. Soltis, G. Sukumar, X. Zhang, H. Caohuy, J. Freedy, C. L. Dalgard, M. D. Wilkerson, H. B. Pollard, B. S. Pollard   +9 more
doaj   +1 more source

Ex vivo activity of cardiac glycosides in acute leukaemia. [PDF]

PLoS ONE, 2011
BACKGROUND: Despite years of interest in the anti-cancerous effects of cardiac glycosides (CGs), and numerous studies in vitro and in animals, it has not yet been possible to utilize this potential clinically. Reports have demonstrated promising in vitro
Helene Hallböök, Jenny Felth, Anna Eriksson, Mårten Fryknäs, Lars Bohlin, Rolf Larsson, Joachim Gullbo   +6 more
doaj   +1 more source

A multicentre registry of hospitalized patients with acute and chronic heart failure: Study design of the H²-registry. [PDF]

ESC Heart Fail
The H2‐Registry: overview, first results and outlook. Abstract Aims Heart failure (HF) is a highly prevalent condition affecting 1–3% of the adult population in Europe. Despite landmark improvements in HF care over the last two decades, hospitalization and mortality rates remain relatively high.
Leiner J, König S, Nitsche A, Hohenstein S, Nagel J, Seyfarth M, Baberg H, Lauten A, Neuser H, Staudt A, Tebbenjohanns J, Andrié R, Niehaus M, Ferrari MW, Kuhlen R, Bollmann A.   +15 more
europepmc   +2 more sources

Estimulación de cardenólidos en brotes de Digitalis purpurea L. cultivados in vitro mediante elicitores

Revista Colombiana de Biotecnología, 2014
Digitalis purpurea L. es una de las principales fuentes de cardenólidos tales como digoxina y digitoxina. Estos fármacos son ampliamente usados en la disfunción cardíaca y para regular las arritmias del corazón.
Naivy Lisbet Pérez-Alonso, Franklyn Arana Labrada, Alina Capote Pérez, Anabel Pérez Pérez, Rafael Sosa, Angel Mollineda, Elio Jiménez González   +6 more
doaj   +1 more source

Chemical Composition of Methanolic Extracts of Scutellaria orientalis L.: Digitoxin and Neocurdione Detection by Gas Chromatography/Mass Spectrometry

Pharmaceutical and Biomedical Research, 2022
Background: Scutellaria orientalis subsp. virens is a species of Scutellaria genus (the Lamiaceae family). The aqueous root extract of S. orientalis has been traditionally used by Iranians to treat neurological disorders, dermatitis, and bronchitis.
Zahra Gharari, Khadijeh Bagheri, Ali Sharafi   +2 more
doaj