Results 61 to 70 of about 11,104 (231)

Krisanaklan Reduces Intestinal Anion and Fluid Secretion Through Inhibition of Na+/K+‐ATPase and K+ Channel Activity

Annals of the New York Academy of Sciences, EarlyView.
Krisanaklan reduces CFTR‐dependent intestinal chloride and fluid secretion by inhibiting the Na+,K+‐ATPase and K+ channels in epithelial cells. Consequently, this natural, plant‐derived product may limit secretory diarrhea caused by a diverse array of microbial pathogens. However, by dissipating the transmembrane Na+ gradient, Krisanaklan also inhibits
Tessa A. Groeneweg, Erdene Baigal, Anny Leung, Gert‐Jan Kremers, Marcel J. C. Bijvelds   +4 more
wiley   +1 more source

In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis

Parasite, 2021
Current treatments of visceral leishmaniasis face limitations due to drug side effects and/or high cost, along with the emergence of parasite resistance. Novel and low-cost antileishmanial agents are therefore required.
Freitas Camila S., Lage Daniela P., Oliveira-da-Silva João A., Costa Rafaella R., Mendonça Débora V.C., Martins Vívian T., Reis Thiago A.R., Antinarelli Luciana M.R., Machado Amanda S., Tavares Grasiele S.V., Ramos Fernanda F., Brito Rory C.F., Ludolf Fernanda, Chávez-Fumagalli Miguel A., Roatt Bruno M., Ramos Gabriela S., Munkert Jennifer, Ottoni Flaviano M., Campana Priscilla R.V., Duarte Mariana C., Gonçalves Denise U., Coimbra Elaine S., Braga Fernão C., Pádua Rodrigo M., Coelho Eduardo A.F.   +24 more
doaj   +1 more source

Digitoxin metabolism by rat liver microsomes. [PDF]

, 1975
Background: Malnutrition among hospitalized patients increases length of stay (LOS) and carries extra hospitalization costs. Objective: To review the impact of malnutrition on hospital LOS and costs in Europe.
Benthe, H.F., Haberland, G., Schmoldt, A.   +2 more
core   +2 more sources

Tetra‐Cationic Pyridyl‐Porphyrins With Peripheral Rhenium(I) Complexes: Photophysics, Photobiological, and BSA‐Binding Properties

European Journal of Inorganic Chemistry, Volume 29, Issue 1, January 1, 2026.
Synthesis, photophysical and electrochemical characterization of tetra‐cationic porphyrins containing Re(I) complexes and BSA‐binding properties In this article, isomeric tetra‐cationic porphyrins with rhenium(I)‐carbonyl‐phenanthroline complexes at the peripheral N‐pyridyl positions 3ReP and 4ReP were evaluated for structural characterization ...
Rafaela C. Copello, André S. Polo, Rafael de Q. Garcia, Leonardo De Boni, Luiz Antônio Sodré Costa, Henrique F. V. Victória, Klaus Krambrock, Otávio A. Chaves, Bernardo A. Iglesias   +8 more
wiley   +1 more source

Investigation of Relationship Between Chemical Stress Factors and Certain Metabolites Including Cardenolides in Callus Cultures of Endemic Turkish Digitalis L. Species

International Journal of Secondary Metabolite, 2017
The aim of the present research is to obtain relationship between different stress treatments [Cu (copper) and Hg (mercury)] and content of cardiac glycosides (digoxigenin, gitoxigenin, lanatoside C, digoxin and digitoxin) as secondary metabolites of ...
Gunce Sahin, Sandeep Kumar Verma, Ekrem Gurel   +2 more
doaj   +1 more source

Steroid Glycosides Hyrcanoside and Deglucohyrcanoside: On Isolation, Structural Identification, and Anticancer Activity

Foods, 2021
Cardiac glycosides (CGs) represent a group of sundry compounds of natural origin. Most CGs are potent inhibitors of Na+/K+-ATPase, and some are routinely utilized in the treatment of various cardiac conditions. Biological activities of other lesser known
Silvie Rimpelová, Tomáš Zimmermann, Pavel B. Drašar, Bohumil Dolenský, Jiří Bejček, Eva Kmoníčková, Petra Cihlářová, Soňa Gurská, Lucie Kuklíková, Marián Hajdůch, Tomáš Ruml, Lubomír Opletal, Petr Džubák, Michal Jurášek   +13 more
doaj   +1 more source

Melanoma: Pathogenesis and Targeted Therapy

MedComm, Volume 7, Issue 1, January 2026.
The treatment landscape for advanced melanoma has evolved significantly. BRAF–MEK inhibitor combinations are standard for BRAF‐mutant melanoma, whereas targeting NRAS mutations is more challenging, with MEK inhibitors like tunlametinib emerging as an option.
Yang Fu, Jie Liu, Zeming Mo, Bin Wang, Yaotiao Deng, Yu Jiang   +5 more
wiley   +1 more source

Employment of artificial intelligence approach for optimizing the solubility of drug in the supercritical CO2 system

Case Studies in Thermal Engineering
This paper investigates the solubility behavior of digitoxin in supercritical carbon dioxide (CO2) through a comprehensive analysis employing ensemble learning techniques and various regression models.
Meixiuli Li, Wenyan Jiang, Shuang Zhao, Kai Huang, Dongxiu Liu   +4 more
doaj   +1 more source

Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death

Molecules, 2016
Despite the available chemotherapy and treatment, leukemia remains a difficult disease to cure due to frequent relapses after treatment. Among the heterogeneous leukemic cells, a rare population referred as the leukemic stem cell (LSC), is thought to be ...
Qian Feng, Wa Seng Leong, Liang Liu, Wai-In Chan   +3 more
doaj   +1 more source

The mechanisms of Chansu in inducing efficient apoptosis in colon cancer cells [PDF]

, 2013
Chansu is one of the most widely used traditional Chinese medicines in China, Japan, and other Southeast Asian countries primarily for antipain, anti-inflammation, and recently anticancer.
Cao, Siyu, Duan, Wei, Good, David, Hashimi, Saeed M., Li, Chun, Mellick, Albert S., Wei, Ming Q.   +6 more
core   +3 more sources