Results 71 to 80 of about 43,790 (236)

Drug‐Induced QT Prolongation: Associations Between Risk Classifications in a Swedish Clinical Decision Support System and Clinical Outcomes

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 503-513, February 2026.
Potential adverse drug events can be signaled in Clinical Decision Support Systems (CDSSs). This study validated a Swedish CDSS (Janusmed Risk Profile) by investigating associations between calculated risk classifications of drugs with QT‐prolonging potential and registered related clinical outcomes.
Ola Nordqvist, Olof Björneld, Patrick Bergman, Björn Wettermark, Alisa Lincke, Marine L. Andersson, Tora Hammar   +6 more
wiley   +1 more source

Digoxin treatment does not reinduce radioiodine uptake in radioiodine refractory non-medullary thyroid carcinoma

European Thyroid Journal
Objective: Patients with non-medullary thyroid carcinoma (NMTC) that are refractory to radioactive iodine (RAI) have a poor prognosis. Strategies for restoring the ability to take up iodine, so-called redifferentiation, are promising but not suitable for
Pepijn van Houten, James Nagarajah, Janneke E W Walraven, Martin Jaeger, Adriana C H van Engen-van Grunsven, Johannes W Smit, Romana T Netea-Maier   +6 more
doaj   +1 more source

Efficient removal of digoxin from aqueous solution using magnetic nanocomposite (Fe3O4–GO–SO3H) as an advanced nano-absorbent

Nanocomposites, 2020
Digoxin separation from pharmaceuticals wastes, is small piece of the larger puzzle in holistic risk assessment. In this study, a novel magnetic nano composite (graphene oxide/Fe3O4/SO3H) was synthesized and used as an absorbent for the removal of ...
Paria Pashazadeh-Panahi, Mohammad Hasanzadeh   +1 more
doaj   +1 more source

Estimation of Digoxin in Chloroform Extract of <i>Moringa concanensis</i> Leaves Using Newly Developed and Validated RP-HPLC Method

, 2023
Tanvi Dodiya, Vaishali Patil
openalex   +2 more sources

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug–Drug Interaction Predictions

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 314-317, February 2026.
Physiology Based Pharmacokinetic (PBPK) modeling is an established essential tool for predicting and/or analyzing drug–drug interactions (DDI). Uncertainty and variability associated with in vitro determined DDI‐related parameters have often been considered a limitation for predicting PBPK‐DDIs.
Kunal S. Taskar, Pradeep Sharma, Karen Rowland Yeo   +2 more
wiley   +1 more source

First‐Line Antiarrhythmic Transplacental Treatment for Fetal Tachyarrhythmia: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThere is no consensus on the most effective and best tolerated first‐line antiarrhythmic treatment for fetal tachyarrhythmia. The purpose of this systematic review and meta‐analysis was to compare the efficacy, safety, and fetal–maternal ...
Tarek Alsaied, Shankar Baskar, Munes Fares, Fares Alahdab, Richard J Czosek, Mohammad Hassan Murad, Larry J Prokop, Allison A Divanovic   +7 more
doaj   +1 more source

Effect of Testosterone Therapy on Cytochrome P450 3A and P‐Glycoprotein Activities Using Midazolam and Digoxin as Probe Substrates Among Transgender Adults

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 2, February 2026.
ABSTRACT Background Gender‐affirming testosterone therapy is one part of the standard of care for more than 1 million transgender adults in the United States. Testosterone therapy may influence the activities of drug‐metabolizing enzymes and transporters, but knowledge about its effect on the pharmacokinetics of other medications is limited.
Michiko Hunter, Rene Coig, Linda Risler, Kristen K. Patton, Radhika R. Narla, Dina N. Greene, Alson K. Burke, Elizabeth Micks, Mary F. Hebert, Lauren R. Cirrincione   +9 more
wiley   +1 more source

Inhibition of P-glycoprotein–Mediated Efflux of Digoxin and Its Metabolites by Macrolide Antibiotics

Journal of Pharmacological Sciences, 2010
This study was conducted to determine the rate of P-glycoprotein (P-gp)–mediated efflux of digoxin analogues and metabolites and to assess the effects of macrolide antibiotics on this efflux.
Jeff Hughes, Andrew Crowe
doaj   +1 more source

Predicting the serum digoxin concentrations of infants in the neonatal intensive care unit through an artificial neural network

BMC Pediatrics, 2019
Background Given its narrow therapeutic range, digoxin’s pharmacokinetic parameters in infants are difficult to predict due to variation in birth weight and gestational age, especially for critically ill newborns. There is limited evidence to support the
Shu-Hui Yao, Hsiang-Te Tsai, Wen-Lin Lin, Yu-Chieh Chen, Chiahung Chou, Hsiang-Wen Lin   +5 more
doaj   +1 more source

Association of Weight Loss Composition Following Metabolic‐Bariatric Surgery With Incident Major Adverse Cardiovascular Events and All‐Cause Mortality

Clinical Obesity, Volume 16, Issue 1, February 2026.
ABSTRACT Severe obesity is associated with an increased cardiovascular risk. Metabolic‐bariatric surgery (MBS) can reduce the risk of cardiovascular events and mortality, potentially depending on weight loss composition. This study assessed the association between post‐MBS weight loss composition and major adverse cardiovascular events (MACE) and all ...
Malou A. H. Nuijten, Bente M. de Roos, Jan H. M. Karregat, Eric J. Hazebroek, Valerie M. Monpellier, Ignace M. C. Janssen, Maria T. E. Hopman, Esmée A. Bakker, Thijs M. H. Eijsvogels   +8 more
wiley   +1 more source