Results 71 to 80 of about 92,853 (340)

Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations

Journal of Pharmacology and Experimental Therapeutics, 2017
Development of submodels of organs within physiologically-based pharmacokinetic (PBPK) principles and beyond simple perfusion limitations may be challenging because of underdeveloped in vitro-in vivo extrapolation approaches or lack of suitable clinical ...
Daniel Scotcher, Christopher R. Jones, A. Galetin, A. Rostami-Hodjegan   +3 more
semanticscholar   +1 more source

Medications, epilepsy and climate change: Added layers of complexity

British Journal of Clinical Pharmacology, EarlyView.
Climate change—the global crisis with pervasive health impacts—has adverse consequences for people with epilepsy (PWE) who have low quality of life due to poor seizure control, socioeconomic disadvantages and comorbidities. This review focuses on the potential effects of climate change on the pharmacological characteristics of antiseizure medications ...
Medine I. Gulcebi, Seyhmus Gavas, Sanjay M. Sisodiya   +2 more
wiley   +1 more source

MONITORING OF SERUM DIGOXIN CONCENTRATION AND SAFETY OF THERAPY WITH DIGOXIN IN PATIENTS WITH ATRIAL FIBRILLATION

Рациональная фармакотерапия в кардиологии, 2018
Background. Monitoring of serum digoxin concentration (SDC) is one of the approaches for controlling the safety of the long-term digoxin treatment, however, the benefits from SDC monitoring in paroxysmal arrhythmias have not been studied.Aim. To evaluate
S. F. Zadvorev, A. A. Yakovlev, A. S. Pushkin, S. A. Rukavishnikova, A. E. Filippov, A. G. Obrezan   +5 more
doaj   +1 more source

Pharmacokinetic Evaluation of a Drug Transporter Cocktail Consisting of Digoxin, Furosemide, Metformin, and Rosuvastatin

Clinical pharmacology and therapy, 2016
This article reports the clinical investigation of a probe drug cocktail containing substrates of key drug transporters. Single oral doses of 0.25 mg digoxin (P‐gp), 5 mg furosemide (OAT1 and OAT3), 500 mg metformin (OCT2, MATE1, and MATE2‐K), and 10 mg ...
P. Stopfer, T. Giessmann, K. Hohl, Ashish Sharma, N. Ishiguro, M. Taub, H. Zimdahl‐Gelling, D. Gansser, M. Wein, T. Ebner, F. Müller   +10 more
semanticscholar   +1 more source

Carvedilol alone or in combination with digoxin for the management of atrial fibrillation in patients with heart failure? [PDF]

, 2003
ObjectivesThis study examined the relative merits of digoxin, carvedilol, and their combination for the management of patients with atrial fibrillation (AF) and heart failure (HF).BackgroundIn patients with AF and HF, both digoxin and beta-blockers ...
Cleland, John G.F, Gemmell, Islay, Khand, Aleem U, Martin, William, Rankin, Andrew C, Taylor, Jacqueline   +5 more
core   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

Bidirectional Tachycardia after an Acute Intravenous Administration of Digitalis for a Suicidal Gesture

Case Reports in Psychiatry, 2014
Acute digoxin intoxication is a life-threating condition associated with severe cardiotoxicity. Female gender, age, low lean body mass, hypertension, and renal insufficiency may worsen the prognosis.
Diletta Sabatini, Giovanni Truscelli, Antonio Ciccaglioni, Carlo Gaudio, Maria Caterina Grassi   +4 more
doaj   +1 more source

Preparation of Nanoparticles of Digoxin Solid Lipid

Chemical Engineering Transactions, 2017
In order to prove the role of solid lipid nanoparticles in oral absorption and bioavailability, the biodegradable monoglyceride with low toxicity and good biocompatibility is used as lipid materials to prepare nanoparticles of digoxin solid lipid and ...
Ping Luo, Yangwu Liu
doaj   +1 more source

National survey of the prevalence, incidence, primary care burden, and treatment of heart failure in Scotland [PDF]

, 2004
Objective: To examine the epidemiology, primary care burden, and treatment of heart failure in Scotland, UK. Design: Cross sectional data from primary care practices participating in the Scottish continuous morbidity recording scheme between 1 April ...
Capewell, S., Chalmers, J., Kirkpatrick, M., MacIntyre, K., McAlister, F.A., McMurray, J., Murphy, N.F., Redpath, A., Simpson, C.R., Stewart, S.   +9 more
core   +2 more sources

Kinetics of digoxin and anti‐digoxin antibody fragments during treatment of digoxin toxicity. [PDF]

British Journal of Clinical Pharmacology, 1989
Anti‐digoxin antibody fragments (ADAF, 80 mg) were infused intravenously to successfully treat severe digoxin toxicity in an 82 year old woman. During treatment, total and free digoxin were determined using an Abbot TDX analyser and an ultrafiltration technique. ADAF were measured by an enzyme‐linked immunosorbent assay.
Pc C. Johnston, Ih H. Stevenson, M. Lemon, Ds S. Hewick, Aj J. Sinclair   +4 more
openaire   +3 more sources