Results 111 to 120 of about 359 (135)
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In Vitro Photosensitization of Human Head and Neck Squamous Cancer Cells by Dihematoporphyrin‐Ether
Otolaryngology–Head and Neck Surgery, 1988In vitro experiments were performed to evaluate the direct cytotoxic and photosensitizing effects of dihematoporphyrin‐ether (DHE) on the head and neck squamous cancer cell line, UM‐SCC‐38. Normal fibroblasts, normal cultured keratinocytes, and the UM‐MEL‐1 pigmented malignant melanoma cell line were used as controls.
S A, Sprik, M J, Sullivan, T E, Carey
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On the Preparation of Dihematoporphyrin Ether-Free Hematoporphyrin Derivative
Biological Chemistry Hoppe-Seyler, 1988A dihematoporphyrin ether-free hematoporphyrin derivative has been prepared by a base-catalysed dehydration of hematoporphyrin with sodium hydroxide. The identification was performed by HPLC and mass spectroscopy (FD-MS). The reaction of hematoporphyrin with 1 M sodium hydroxide for 24 h yields more than 90% of the monomeric porphyrins.
H, Häberlein, P, Both, M O, Doss
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Transcutaneous Determination of Tissue Dihematoporphyrin Ether Content
Archives of Dermatology, 1991• Photodynamic therapy involves the use of light of appropriate wavelength to excite a photosensitizer resulting in tissue destruction. The photosensitizer dihematoporphyrin ether is selectively retained in tumors allowing for tumor destruction while sparing normal structures. Accessibility of skin tumors makes them well suited for photodynamic therapy.
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Photochemistry and Photobiology, 1987
Abstract Results of dihematoporphryin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40‐60 μg DHE g−1 of tissue at an injected dose of 40 mg kg−1. Previously concentrations on this order have primarily been found in organs of the reticuloendothelial system.
T S, Mang, T J, Wieman
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Abstract Results of dihematoporphryin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40‐60 μg DHE g−1 of tissue at an injected dose of 40 mg kg−1. Previously concentrations on this order have primarily been found in organs of the reticuloendothelial system.
T S, Mang, T J, Wieman
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ON THE PREPARATION and PROPERTIES OF DIHEMATOPORPHYRIN ETHER, THE TUMOR‐LOCALIZING COMPONENT OF HPD*
Photochemistry and Photobiology, 1985Abstract—A porphyrin mixture derived from hematoporphyrin and termed HPD (hematoporphyrin derivative) is used for localization and therapy of tumors. The major localizing component of HPD has been provisionally identified as a dihematoporphyrin ether (DHE).
D, Kessel, M L, Cheng
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Archives of Dermatology, 1990
• Differences in skin pigmentation may significantly affect light penetration during photodynamic therapy. This study evaluated the effect of skin pigmentation on dermatotoxic reaction to photodynamic therapy utilizing the photosensitizer dihematoporphyrin ether. Black and white guinea pigs were given 10 mg/kg of dihematoporphyrin ether, depilated, and
E F, Bernstein +8 more
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• Differences in skin pigmentation may significantly affect light penetration during photodynamic therapy. This study evaluated the effect of skin pigmentation on dermatotoxic reaction to photodynamic therapy utilizing the photosensitizer dihematoporphyrin ether. Black and white guinea pigs were given 10 mg/kg of dihematoporphyrin ether, depilated, and
E F, Bernstein +8 more
exaly +5 more sources
Photochemistry and Photobiology, 1987
Abstract Natural history studies of patients with macular subretinal neovascularization as a complication of age‐related macular degeneration have shown a poor visual outcome, with 77% losing more than 4 lines of vision and 64% losing 6 lines at 24 months after presentation.
E L, Thomas, M, Langhofer
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Abstract Natural history studies of patients with macular subretinal neovascularization as a complication of age‐related macular degeneration have shown a poor visual outcome, with 77% losing more than 4 lines of vision and 64% losing 6 lines at 24 months after presentation.
E L, Thomas, M, Langhofer
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Archives of Otolaryngology - Head and Neck Surgery, 1989
Hematoporphyrin derivative and its newly purified form, dihematoporphyrin ether, have been shown to localize selectively in malignant tissues and virally induced papillomas. Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by UV light.
M J, Shikowitz +3 more
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Hematoporphyrin derivative and its newly purified form, dihematoporphyrin ether, have been shown to localize selectively in malignant tissues and virally induced papillomas. Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by UV light.
M J, Shikowitz +3 more
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Movement Disorders, 1992
AbstractThe use of local dihematoporphyrin ether (DHE) injections, followed by laser light activation, was investigated as a potential permanent myectomy treatment for muscle spasms, in particular blepharospasm and hemifacial spasm. DHE was injected into the eyelids of rabbits, followed by laser activation, as used in photochemotherapy. Four days after
J D, Wirtschafter +4 more
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AbstractThe use of local dihematoporphyrin ether (DHE) injections, followed by laser light activation, was investigated as a potential permanent myectomy treatment for muscle spasms, in particular blepharospasm and hemifacial spasm. DHE was injected into the eyelids of rabbits, followed by laser activation, as used in photochemotherapy. Four days after
J D, Wirtschafter +4 more
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Biological Chemistry Hoppe-Seyler, 1991
Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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Rat liver cells incorporate monomeric as well as dimeric hematoporphyrin derivatives. Time-dependent incubation assays gave evidence that monomeric compounds are more efficiently incorporated compared to protoporphyrin dimethyl ester hematoporphyrin ether.
P, Both +4 more
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