Results 111 to 120 of about 130,200 (126)
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THYMIDINE UPTAKE, INCORPORATION AND DNA POLYMERASE ACTIVITY IN MURINE BLADDER TUMOR CELL,MBT–2, EXPOSED TO UV ACTIVATED DIHEMATOPORPHYRIN ETHER

Photochemistry and Photobiology, 1988
Abstract— Photodynamic therapy (PDT) is a new modality for treatment of malignancy. In this paper, we reported the effect of UV activated dihematoporphyrin ether (DHE) on [3H] thymidine uptake and DNA synthesis in murine bladder tumor cells,MBT–2. Exponentially growing cells were pretreated with 0.05–5μg/ml of DHE for 30 min in complete darkness prior ...
M T, Tseng, Y H, Ling, J I, Harty
exaly   +3 more sources

A Langmuir-Blodgett study of the orientation of the cancer photoradiation therapy drug dihematoporphyrin ether at water-air and water-fatty-acid-air interfaces

Thin Solid Films, 1986
Abstract The fluorescent molecule dihematoporphyrin ether (DHE), which is known to become sequestered in cells and which is currently being used for “photoradiation” cancer therapy in clinical trials, may organize into two-dimensional arrays at a water-membrane interface.
Dietmar Möbius
exaly   +3 more sources

Biodistribution of Indium-III Dihematoporphyrin Ether in Papillomas and Body Tissues and its Relevance to Photodynamic Therapy

1988
Hematoporphyrin derivative (HPD) and its newly purified form, dihematoporphyrin ether (DUE) have been shown to selectively localize in malignant tissues and virally induced papillomas (Sliikowitz et.al.). Its use as a probe to distinguish tumors from normal tissues has been largely based on its fluorescence when activated by ultraviolet light.
Mark J Shikowitz
exaly   +2 more sources

Dihematoporphyrin Ether Clearance in Primate Bladders

Journal of Urology, 1986
The techniques of in vivo tissue fluorescence photometry and chemical extractions of DHE, which have been recently developed in our laboratory, were employed to study DHE uptake and clearance in the primate bladders. Data show these techniques are readily applicable in studying porphyrin uptake and clearance in primate bladders.
U O, Nseyo, T S, Mang, W R, Potter
openaire   +2 more sources

The binding of dihematoporphyrin ether (photofrin II) to human serum albumin

Clinica Chimica Acta, 1985
The variable aggregation of porphyrins such as Hp and Hpd introduces uncertainties and errors into attempts to measure their binding to proteins. Methods such as dialysis, ultrafiltration and gel chromatography, so frequently used, proved to be unreliable when applied to the binding of Hp to serum albumin. Quenching of tryptophan fluorescence will only
J, Moan, C, Rimington, A, Western
openaire   +2 more sources

PHOTODYNAMIC THERAPY IN THE TREATMENT OF PANCREATIC CARCINOMA: DIHEMATOPORPHYRIN ETHER UPTAKE and PHOTOBLEACHING KINETICS

Photochemistry and Photobiology, 1987
Abstract Results of dihematoporphryin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40‐60 μg DHE g−1 of tissue at an injected dose of 40 mg kg−1. Previously concentrations on this order have primarily been found in organs of the reticuloendothelial system.
T S, Mang, T J, Wieman
openaire   +2 more sources

DIHEMATOPORPHYRIN ETHER‐PHOSPHOLIPID INTERACTIONS. THE ROLES OF SURFACE CHARGE and LATERAL PHASE SEPARATIONS

Photochemistry and Photobiology, 1987
Abstract Fluorescence spectroscopy was utilized to investigate the equilibrium interaction of dihem‐atoporphyrin ether(s) (DHE) with binary and ternary phospholipid mixtures of defined composition in order to define the roles of net negative surface charge and lateral phase separations in DHE‐membrane partitioning. Binary phospholipid mixtures employed
S E, Kendrick   +5 more
openaire   +2 more sources

CLOSURE OF EXPERIMENTAL SUBRETINAL NEOVASCULAR VESSELS WITH DIHEMATOPORPHYRIN ETHER AUGMENTED ARGON GREEN LASER PHOTOCOAGULATION

Photochemistry and Photobiology, 1987
Abstract Natural history studies of patients with macular subretinal neovascularization as a complication of age‐related macular degeneration have shown a poor visual outcome, with 77% losing more than 4 lines of vision and 64% losing 6 lines at 24 months after presentation.
E L, Thomas, M, Langhofer
openaire   +2 more sources

An Investigation Of Photodynamic Therapy In The Treatment Of Pancreatic Carcinoma: Dihematoporphyrin Ether Uptake And Photobleaching Kinetics

SPIE Proceedings, 1988
Results of dihematoporphyrin ether (DHE) uptake and fluorescence kinetics show that the concentration in the pancreas is on the order of 40-60 μg DHE/g of tissue at an injected dose of 40 mg/kg. Previously concentrations on this order have only been found in organs of the reticuloendothelial system.
Thomas S. Mang, Thomas J. Wieman
openaire   +1 more source

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