Results 1 to 10 of about 217,358 (308)

Cymoxanil disrupts RNA synthesis through inhibiting the activity of dihydrofolate reductase [PDF]

Scientific Reports
The agricultural fungicide cymoxanil (CMX) is commonly used in the treatment of plant pathogens, such as Phytophthora infestans. Although the use of CMX is widespread throughout the agricultural industry and internationally, the exact mechanism of action
Thomas David Daniel Kazmirchuk, Daniel. J. Burnside, Jiashu Wang, Sasi Kumar Jagadeesan, Mustafa Al-gafari, Eshan Silva, Taylor Potter, Calvin Bradbury-Jost, Nishka Beersing Ramessur, Brittany Ellis, Sarah Takallou, Maryam Hajikarimlou, Houman Moteshareie, Kamaleldin B. Said, Bahram Samanfar, Eugene Fletcher, Ashkan Golshani   +16 more
doaj   +4 more sources

Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans

mSphere, 2020
While the folate biosynthetic pathway has provided a rich source of antibacterial, antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely antifungal agents.
Christian DeJarnette, Arturo Luna-Tapia, Leanna R. Estredge, Glen E. Palmer   +3 more
doaj   +2 more sources

Dihydrofolate Reductase [PDF]

Catalysis from A to Z, 2020
Dihydrofolate reductase (187 aa, ~21 kDa) is encoded by the human DHFR gene. This protein is involved in folate metabolism and the synthesis of nucleotides and glycine.
C. Wong
openaire   +2 more sources

Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase [PDF]

Antibiotics, 2022
Resistance to trimethoprim and other antibiotics targeting dihydrofolate reductase may arise in bacteria harboring an atypical, plasmid-encoded, homotetrameric dihydrofolate reductase, called R67 DHFR. Although developing inhibitors to this enzyme may be
Pedro J. Silva
doaj   +2 more sources

Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors

BMC Chemistry, 2019
Background Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibition dihydrofolate reductase (DHFR)
Essam M. Hussein, Munirah M. Al-Rooqi, Shimaa M. Abd El-Galil, Saleh A. Ahmed   +3 more
doaj   +2 more sources

Computational identification of candidate inhibitors for Dihydrofolate reductase in Acinetobacter baumannii [PDF]

Current Research in Structural Biology
Acinetobacter baumannii is one of the emerging causes of hospital acquired infections and this bacterium, due to multi-drug resistant and Extensive Drug resistant has been able to develop resistance against the antimicrobial agents that are being used to
Saurabh Kumar Bhati, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh   +3 more
doaj   +2 more sources

Divergent evolution of protein conformational dynamics in dihydrofolate reductase. [PDF]

Nature Structural &Molecular Biology, 2013
Molecular evolution is driven by mutations, which may affect the fitness of an organism and are then subject to natural selection or genetic drift. Analysis of primary protein sequences and tertiary structures has yielded valuable insights into the ...
Bhabha, Gira, Dyson, H Jane, Ekiert, Damian C, Godzik, Adam, Jennewein, Madeleine, Kroon, Gerard, Tuttle, Lisa M, Wilson, Ian A, Wright, Peter E, Zmasek, Christian M   +9 more
core   +3 more sources

DHFR (dihydrofolate reductase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2018
Dihydrofolate reductase (DHFR) is a member of the reductase enzyme family, which is ubiquitously expressed in all organisms. Levels of this enzyme peak at the G1/S cell cycle boundary. Autoregulation, through DHFR-RNA interactions, has also been reported.
Krajinovic, Maja, Abaji, Rachid, Sharif-Askari, Bahram   +2 more
openaire   +3 more sources

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility [PDF]

Cell Death and Disease, 2022
High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS).
Yingying Ma, Meiqi Yi, Weixuan Wang, Xiaohui Liu, Qingtao Wang, Chongdong Liu, Yuling Chen, Haiteng Deng   +7 more
doaj   +2 more sources

Unveiling the Efficacy of Sesquiterpenes from Marine Sponge Dactylospongia elegans in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies. [PDF]

Molecules, 2023
Omar AM, Mohammad KA, Sindi IA, Mohamed GA, Ibrahim SRM.   +4 more
europepmc   +3 more sources