Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase [PDF]
Antibiotics, 2022 Resistance to trimethoprim and other antibiotics targeting dihydrofolate reductase may arise in bacteria harboring an atypical, plasmid-encoded, homotetrameric dihydrofolate reductase, called R67 DHFR. Although developing inhibitors to this enzyme may be
Pedro J. Silva
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Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility [PDF]
Cell Death and Disease, 2022 High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS).
Yingying Ma +7 more
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Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase [PDF]
Cell Death and Disease, 2021 Metformin, the first-line drug for type II diabetes, has recently been considered an anticancer agent. However, the molecular target and underlying mechanism of metformin’s anti-cancer effects remain largely unclear.
Yinghui Wang +14 more
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The effects of exposed Black seed (Nigella sativa L.) callus by gamma rays on specific activity of dihydrofolate reductase and folate content Extracted from it [PDF]
مجلة التربية والعلم, 2008 The present study was conducted to determine the effects of gamma rays on specific activity of dihydrofolate reductase and folate content of Black seed (Nigella sativa L.) callus. The effect was dependent on doses of gamma rays.
Sajeda Abood
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Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine. [PDF]
PLoS ONE, 2009 Sulfadoxine-pyrimethamine was a common first line drug therapy to treat uncomplicated falciparum malaria, but increasing therapeutic failures associated with the development of significant levels of resistance worldwide has prompted change to alternative
David J Bacon +11 more
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mSphere, 2020 While the folate biosynthetic pathway has provided a rich source of antibacterial, antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely antifungal agents.
Christian DeJarnette +3 more
doaj +1 more source
Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
Journal of Research in Medical Sciences, 2020 Background: DNA methylation was considered to play an important role in hypertension. However, the direct association between dihydrofolate reductase (DHFR) promoter methylation and hypertension remains unclear.
Guodong Xu +10 more
doaj +1 more source
Identification of the molecular mechanism of christinin compounds from Arabian bidara leaves (Ziziphus spina-christi L.) on microorganisms that cause female genital problems through computational approaches [PDF]
Pharmaciana, 2020 Arabian bidara leaves (Ziziphus spina-christi, L.) are known to have strong antimicrobial activity against microorganisms that cause infection in the female genital area, namely Staphylococcus aureus bacteria and Candida albicans fungi. They contain main
Fitrianti Darusman +1 more
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Sampling of conformational ensemble for virtual screening using molecular dynamics simulations and normal mode analysis [PDF]
, 2015 Aim: Molecular dynamics simulations and normal mode analysis are well-established approaches to generate receptor conformational ensembles (RCEs) for ligand docking and virtual screening.
David Perahia +10 more
core +4 more sources
Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]
, 1991 With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Becker, Karin +7 more
core +3 more sources