Results 91 to 100 of about 48,162 (258)

Stepwise Acquisition of Pyrimethamine Resistance in the Malaria Parasite [PDF]

, 2013
The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate antimalarials. We studied the possible evolutionary pathways in the evolution of pyrimethamine resistance using an approach in which ...
Brown, Kyle M., Chookajorn, Thanat, Hartl, Daniel L., Imwong, Mallika, Kamchonwongpaisan, Sumalee, Lozovsky, Elena, Neafsey, Daniel Edward, Shaw, Philip J., Weinreich, Daniel M.   +8 more
core   +1 more source

Computational identification of candidate inhibitors for Dihydrofolate reductase in Acinetobacter baumannii

Current Research in Structural Biology
Acinetobacter baumannii is one of the emerging causes of hospital acquired infections and this bacterium, due to multi-drug resistant and Extensive Drug resistant has been able to develop resistance against the antimicrobial agents that are being used to
Saurabh Kumar Bhati, Monika Jain, Jayaraman Muthukumaran, Amit Kumar Singh   +3 more
doaj  

Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism

Viruses
Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance of the dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide reductase (
Shih-Yen Lo, Meng-Jiun Lai, Chee-Hing Yang, Hui-Chun Li   +3 more
doaj   +1 more source

Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia. [PDF]

, 2005
In the Maheba Refugee Settlement, in the clinics supported by Medecins Sans Frontieres, all children aged up to 5 years with a confirmed diagnosis of uncomplicated falciparum malaria are treated with the combination of sulfadoxine/pyrimethamine (SP) and ...
Bloland PB, Contamin H, National Malaria Control Centre, Nosten F, Peterson DS, Trape JF, Vasconcelos KF, White NJ, World Health Organisation (WHO), World Health Organisation (WHO)   +9 more
core   +2 more sources

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis [version 1; referees: 2 approved]

F1000Research, 2015
Dihydrofolate reductase from Escherichia coli (ecDHFR) serves as a model system for investigating the role of protein dynamics in enzyme catalysis. We discuss calculations predicting a network of dynamic motions that is coupled to the chemical step ...
Amnon Kohen
doaj   +1 more source

E84G mutation in dihydrofolate reductase from drug resistant strains of Mycobacterium tuberculosis (Mumbai, India) leads to increased interaction with Trimethoprim

International Journal of Mycobacteriology, 2015
Background: Dihydrofolate reductase (DHFR) (dfrA gene) is an essential enzyme for cell survival and an unexplored target in Mycobacterium tuberculosis (Mtb). This study was carried out to analyze mutations in the dfrA gene amongst 20 clinical DNA samples
Archana Raju, Savita Kulkarni, M K Ray, M G.R Rajan, Mariam S Degani   +4 more
doaj   +1 more source

Translocation arrest by reversible folding of a precursor protein imported into mitochondria [PDF]

, 1989
Passage of precursor proteins through translocation contact sites of mitochondria was investigated by studying the import of a fusion protein consisting of the NH2-terminal 167 amino acids of yeast cytochrome b2 precursor and the complete mouse ...
Guiard, Bernard, Hartl, Franz-Ulrich, Herzog, Volker, Neupert, Walter, Rassow, Joachim, Wienhues, Ulla   +5 more
core  

Old Doubts From a New Perspective: Oral Versus Subcutaneous Methotrexate

International Journal of Dermatology, Volume 64, Issue 9, Page 1535-1537, September 2025.
Laura Kiss, Rolland Gyulai
wiley   +1 more source

A Two-Enzyme Adaptive Unit within Bacterial Folate Metabolism

Cell Reports, 2019
Summary: Enzyme function and evolution are influenced by the larger context of a metabolic pathway. Deleterious mutations or perturbations in one enzyme can often be compensated by mutations to others.
Andrew F. Schober, Andrew D. Mathis, Christine Ingle, Junyoung O. Park, Li Chen, Joshua D. Rabinowitz, Ivan Junier, Olivier Rivoire, Kimberly A. Reynolds   +8 more
doaj  

Substrate Specificity Analysis of Dihydrofolate/Dihydromethanopterin Reductase Homologs in Methylotrophic α-Proteobacteria

Frontiers in Microbiology, 2018
Methane-producing archaea and methylotrophic bacteria use tetrahydromethanopterin (H4MPT) and/or tetrahydrofolate (H4F) as coenzymes in one-carbon (C1) transfer pathways.
Mark Burton, Chidinma Abanobi, Kate Tzu-Chi Wang, Yihua Ma, Madeline E. Rasche   +4 more
doaj   +1 more source