Results 101 to 110 of about 48,162 (258)

A silent sulfonamide-resistant microbial world: The curious case of missing DHPS in candidate phyla radiation

Journal of Global Antimicrobial Resistance
Candidate phyla radiation (CPR) microbes exhibit minimal genomes, episymbiotic/parasitic lifestyles, and metabolic dependencies on host cells. In this study, we look for the presence of dihydropteroate synthase (DHPS) and dihydrofolate reductase, key ...
Riyad Razzouk, Adel Azour, Jean-Marc Rolain, Fadi Bittar   +3 more
doaj  

Cloning and expression of ricin a- and b-subunits genes in fusion constructions with dihydrofolate reductase gene in escheriсhia coli.

Тонкие химические технологии, 2007
Recombinant chimeric constructions RTA-DHFR and RTВ-DHFR consisting of ricin Aand B-subunits genes (RTA and RTB) and dihydrofolate reductase (DHFR) gene were cloned and expressed in Escheriсhia coli.
M. А. Gracheva, Z. М. Galushkina, N. N. Poletaeva, L. V. Verhovskaya, V. G. Lunin, V. I. Shvets   +5 more
doaj  

Multiparameter Screening on SlipChip Used for Nanoliter Protein Crystallization Combining Free Interface Diffusion and Microbatch Methods [PDF]

, 2010
This paper describes two SlipChip-based approaches to protein crystallization: a SlipChip-based free interface diffusion (FID) method and a SlipChip-based composite method that simultaneously performs microbatch and FID crystallization methods in a ...
Du, Wenbin, Ismagilov, Rustem F., Li, Liang   +2 more
core   +1 more source

Pyrimido-Pyrimidines: A Novel Class of Dihydrofolate Reductase Inhibitors

Food Technology and Biotechnology, 2009
Inhibitors of dihydrofolate reductase (DHFR), an enzyme that catalyzes 5,6,7,8-tetrahydrofolate synthesis, have been used as antimicrobial as well as antimetabolite drugs for a long time. Although structurally belonging to different classes, the majority
Iva Tatic, Zrinka Ivezic, Sanja Tomic, Jerka Dumic, Mihailo Banjanac   +4 more
doaj  

Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Scientia Pharmaceutica, 2017
Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in ...
Pimonluck Sittikornpaiboon, Pisanu Toochinda, Luckhana Lawtrakul   +2 more
doaj   +1 more source

Antibacterial Potential of Ximenia americana L. Olacaceae: Molecular Docking, Molecular Dynamics, and ADMET Prediction

Journal of Pharmacy
Introduction:  The devastating effect of persistent and recurrent bacterial infections coupled with antibiotic resistance is a driving force for prospects into alternative antibacterial therapeutics to achieve treatment.
Mubarak Muhammad Dahiru, Abdulazeez Mumsiri Abaka, Ibrahim Ya'u   +2 more
doaj   +1 more source

Inhibitors of dihydrofolate reductase in leishmania and trypanosomes

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002
The protozoan diseases leishmaniasis, Chagas' disease and African trypanosomiasis are major health problems in many countries, particularly developing countries, and there are few drugs available to treat these diseases. Dihydrofolate reductase (DHFR) inhibitors have been used successfully in the treatment of a number of other diseases such as cancer ...
openaire   +4 more sources

A Direct Assay for Dihydrofolate Reductase in Human Leukocytes [PDF]

, 1964
D. K. MISRA
openalex   +1 more source

A single-domain protein catenane of dihydrofolate reductase. [PDF]

Natl Sci Rev, 2023
Fang J, Li T, Lee J, Im D, Xu L, Liu Y, Seo J, Zhang WB.   +7 more
europepmc   +1 more source

A Case of Diverticular Perforation in a Young Patient with Rheumatoid Arthritis on Methotrexate

Case Reports in Medicine, 2015
Background. Disease-modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX), are associated with gastrointestinal toxicity. MTX inhibits dihydrofolate reductase, but it is unclear if polymorphisms of the methylenetetrahydrofolate reductase ...
Ian Chang, Carla Guggenheim, Heather Laird-Fick   +2 more
doaj   +1 more source