Results 101 to 110 of about 217,358 (308)

Do We Need to Worry About Staphylococcus epidermidis ST0409KOC, a Cheese‐Isolated Strain With Bacteriocinogenic Properties?

Molecular Nutrition &Food Research, Volume 70, Issue 1, January 2026.
Bacteriocinogenic Staphylococcus epidermidis ST0409KOC was isolated from cheese and characterized as bacteriocin‐producing with strong activity versus Listeria monocytogenes and other pathogens. S. epidermidis ST0409KOC can be considered a safe strain regarding its virulence genetic background, presenting only a single virulence gene of IS257 among the
Kayque Ordonho Carneiro, João Marcos Scafuro Lima, Svetoslav Dimitrov Todorov   +2 more
wiley   +1 more source

NOX isoforms in the development of abdominal aortic aneurysm

Redox Biology, 2017
Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal role of uncoupled eNOS in this severe human disease.
Kin Lung Siu, Qiang Li, Yixuan Zhang, Jun Guo, Ji Youn Youn, Jie Du, Hua Cai   +6 more
doaj   +1 more source

High prevalence of double Plasmodium falciparum dhfr mutations at codons 108 and 59 in the Sistan-Baluchistan province, Iran [PDF]

, 2003
info:eu-repo/semantics ...
Bereckzy, S, Bjorkman, A, Djadid, ND, Gil, José Pedro, Zakeri, S   +4 more
core   +1 more source

Microbiological Safety of Probiotic Food Supplements

Food Risk Assess Europe, Volume 4, Issue 1, January 2026.
Background Probiotic food supplements (FS) containing live bacteria cultures are widespread in Switzerland. The aim of the study conducted in 2024 was to evaluate the microbiological safety of these products and to review compliance with the legal requirements in accordance with the Ordinance on Food Supplements (VNem, SR 817.022.14).
Dominik Ziegler, Jasmin Stark, Simon Meier, Peter Brodmann   +3 more
wiley   +1 more source

How native state topology affects the folding of Dihydrofolate Reductase and Interleukin-1beta

, 2000
The overall structure of the transition state and intermediate ensembles experimentally observed for Dihydrofolate Reductase and Interleukin-1beta can be obtained utilizing simplified models which have almost no energetic frustration.
Alm, C. Clementi, Dill, Galzitskaya, Heidary, J. N. Onuchic, JONES, Jones, Jones, Klimov, Kuwajima, Leopold, Li, Mirny, Munoz, Nelson, Nymeyer, Onuchic, Onuchic, Onuchic, P. A. Jennings, Plaxco, Shea, Sobolev, Varley   +24 more
core   +2 more sources

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Efficient Enrichment of Gene-Modified Primary T Cells via CCR5-Targeted Integration of Mutant Dihydrofolate Reductase

Molecular Therapy: Methods & Clinical Development, 2018
Targeted gene therapy strategies utilizing homology-driven repair (HDR) allow for greater control over transgene integration site, copy number, and expression—significant advantages over traditional vector-mediated gene therapy with random genome ...
Biswajit Paul, Guillermo S. Romano Ibarra, Nicholas Hubbard, Teresa Einhaus, Alexander Astrakhan, David J. Rawlings, Hans-Peter Kiem, Christopher W. Peterson   +7 more
doaj   +1 more source

Soluble oligomerization provides a beneficial fitness effect on destabilizing mutations. [PDF]

, 2011
Protein stability is widely recognized as a major evolutionary constraint. However, the relation between mutation-induced perturbations of protein stability and biological fitness has remained elusive.
Eugene Shakhnovich, Shimon Bershtein
core   +1 more source

Bioinformatic Analysis for the Validation of Novel Biomarkers for Cancer Diagnosis and Drug Sensitivity [PDF]

, 2015
Background: The genetic control of tumour progression presents the opportunity for bioinformatics and gene expression data to be used as a basis for tumour grading.
Lockwood, Laura Anne Rebecca
core   +2 more sources

Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum

PLoS ONE, 2011
Background Patterns of emerging drug resistance reflect the underlying adaptive landscapes for specific drugs. In Plasmodium falciparum, the parasite that causes the most serious form of malaria, antifolate drugs inhibit the function of essential enzymes
Marna S. Costanzo, Kyle M. Brown, D. Hartl   +2 more
semanticscholar   +1 more source