Results 11 to 20 of about 217,358 (308)

Large cosolutes, small cosolutes, and dihydrofolate reductase activity [PDF]

Protein Science, 2017
Luis C. Acosta, Gerardo M. Perez Goncalves, Gary J. Pielak, Annelise H. Gorensek‐Benitez   +3 more
openalex   +2 more sources

Disparate selection of mutations in the dihydrofolate reductase gene (dhfr) of Plasmodium ovale curtisi and P. o. wallikeri in Africa. [PDF]

PLoS Negl Trop Dis, 2022
Chen J, Ma X, Tang J, Xu S, Gu Y, Tang F, Cao Y, Wang W, Zhou H, Zhang J, Yu X, Zhu G, Zhu M, Zhang Q, Culleton R, Liu Y, Cao J.   +16 more
europepmc   +3 more sources

Methotrexate binding to dihydrofolate reductase [PDF]

Nature, 1980
Gordon C. K. Roberts, J. Feeney, B. Birdsall, Peter Charlton, Douglas W. Young   +4 more
openalex   +3 more sources

Effects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamine. [PDF]

PLoS ONE, 2009
Sulfadoxine-pyrimethamine was a common first line drug therapy to treat uncomplicated falciparum malaria, but increasing therapeutic failures associated with the development of significant levels of resistance worldwide has prompted change to alternative
David J Bacon, Doug Tang, Carola Salas, Norma Roncal, Carmen Lucas, Lucia Gerena, Lorena Tapia, A Alejandro Llanos-Cuentas, Coralith Garcia, Lelv Solari, Dennis Kyle, Alan J Magill   +11 more
doaj   +1 more source

Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese

Journal of Research in Medical Sciences, 2020
Background: DNA methylation was considered to play an important role in hypertension. However, the direct association between dihydrofolate reductase (DHFR) promoter methylation and hypertension remains unclear.
Guodong Xu, Zhiyi Wang, Lian Li, Wenxia Li, Jingcen Hu, Shuyu Wang, Hongxia Deng, Bo Li, Changyi Wang, Zhishen Shen, Liyuan Han   +10 more
doaj   +1 more source

Identification of the molecular mechanism of christinin compounds from Arabian bidara leaves (Ziziphus spina-christi L.) on microorganisms that cause female genital problems through computational approaches [PDF]

Pharmaciana, 2020
Arabian bidara leaves (Ziziphus spina-christi, L.) are known to have strong antimicrobial activity against microorganisms that cause infection in the female genital area, namely Staphylococcus aureus bacteria and Candida albicans fungi. They contain main
Fitrianti Darusman, Taufik Muhammad Fakih   +1 more
doaj   +1 more source

The requirement of matrix ATP for the import of precursor proteins into the mitochondrial matrix and intermembrane space [PDF]

, 1994
The role of ATP in the matrix for the import of precursor proteins into the various mitochondrial subcompartments was investigated by studying protein translocation at experimentally defined ATP levels.
Gruhler, Albrecht, Guiard, Bernard, Klei, Ida J. van der, Koll, Hans, Neupert, Walter, Stuart, Rosemary A.   +5 more
core   +11 more sources

Sampling of conformational ensemble for virtual screening using molecular dynamics simulations and normal mode analysis [PDF]

, 2015
Aim: Molecular dynamics simulations and normal mode analysis are well-established approaches to generate receptor conformational ensembles (RCEs) for ligand docking and virtual screening.
David Perahia, Divij Goyal, Gautier Moroy, Karen Druart, Maria A Miteva, Miteva MA, Olivier Sperandio, Saurabh Khemka, Shakti Rielland, Trott O, Xu X   +10 more
core   +4 more sources

Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors

Journal of antibiotics (Tokyo. 1968), 2019
The development of new mechanisms of resistance among pathogens, the occurrence and transmission of genes responsible for antibiotic insensitivity, as well as cancer diseases have been a serious clinical problem around the world for over 50 years ...
Agnieszka Wróbel, Karolina Arciszewska, Dawid Maliszewski, D. Drozdowska   +3 more
semanticscholar   +1 more source

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]

, 1991
With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Becker, Karin, Guiard, Bernard, Horwich, Arthur, Neupert, Walter, Pfanner, Nikolaus, Schleyer, Manfred, Tropschug, Maximilian, Wienhues, Ulla   +7 more
core   +3 more sources