Results 61 to 70 of about 736 (160)

Roles of Ferric Peroxide Anion Intermediates (Fe3+O2−, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model

Angewandte Chemie, Volume 136, Issue 33, August 12, 2024.
Although most cytochrome P450‐catalyzed oxidations are believed to utilize perferryl oxygen (Compound I) as a reactive iron species, the ferric peroxide species (Compound 0) is thought to catalyze some oxidative deformylations. This study revealed the dominant contribution of Compound 0 in the P450 19A1‐catalyzed steroid aromatization and P450 2B4 ...
Yasuhiro Tateishi, Kevin D. McCarty, Martha V. Martin, Francis K. Yoshimoto, F. Peter Guengerich   +4 more
wiley   +1 more source

Recent developments in fluorine‐containing pesticides

Pest Management Science, Volume 80, Issue 7, Page 3065-3087, July 2024.
In the timeframe 2016–2022, approximately 77% of the 39 launched products (herbicides, fungicides, insecticides, acaricides, and nematicides) were halogen‐substituted and from these, approximately 64% were fluorine‐containing pesticides. Abstract To ensure ongoing sustainability, the modern agrochemical industry is faced with enormous challenges. These
Peter Jeschke
wiley   +1 more source

Composition of cholesterol and its precursors in ovine milk

, 2003
International audienceIdentification and concentration of cholesterol and its precursors were investigated in ovine milk. In order to ensure a wide variety of milk composition, 45 samples were taken during the year from the bulk milk of five herds ...
Fraga, Maria, Goudjil, Hanane, Juárez, Manuela, Torrado, Susana, Fontecha, Javier, Martínez-Castro, Isabel   +5 more
core   +1 more source

Ketoconazole-mediated growth inhibition in Botrytis cinerea and Saccharomyces cerevisiae

, 1993
Minimum inhibitory concentrations (MIC) for Botrytis cinerea and Saccharomyces cerevisiae with ketoconazole were 10 μg ml- 1 and 20 μg ml- 1, respectively.
M. A. Quail, Michael A. Quail, M. W. Goosey, Deborah J. Moore, Steven L. Kelley, A. Arnoldi, D. J. Moore, Anna Arnold, Michael W. Goosey, S. L. Kelley   +9 more
core   +1 more source

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase [PDF]

, 2011
SummaryExquisite control of cholesterol synthesis is crucial for maintaining homeostasis of this vital yet potentially toxic lipid. Squalene monooxygenase (SM) catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before ...
Gill, Saloni, Julian Stevenson, Andrew J. Brown, Brown, Andrew J., Ika Kristiana, Kristiana, Ika, Saloni Gill, Stevenson, Julian   +7 more
core   +1 more source

Extraction, purification and biological activity of total triterpenes from Sanghuangporus sanghuang

Guangxi Zhiwu
In order to optimize the extraction process of total triterpenes from Sanghuangporus sanghuang, to purify total triterpenes, and to analyze its chemical components, as well as its antitumor and antioxidant activities. The response surface method was used
LIU Kun1,2, FU Xinyao1, GUO Tong1, ZHANG Wanyue1, ZHAO Qingsheng3, KONG Zejuan4, CHENG Hua4*, SONG Heng5
doaj   +1 more source

Synthesis of 15.ALPHA.-Fluoro-24,25-dihydrolanosterol as a Potential Inhibitor and/or Mechanistic Probe for Lanosterol 14.ALPHA.-Demethylase.

Chemical and Pharmaceutical Bulletin, 2000
As a potential inhibitor and/or mechanistic probe for lanosterol 14alpha-demethylase, 15alpha-fluoro-24,25-dihydrolanosterol was prepared by fluorination of 15alpha-hydroxy-24,25-dihydrolanost-7-en-3beta-yl benzoate with diethylaminosulfur trifluoride, followed by hydrogen chloride-catalyzed isomerization of the delta7 to delta8 and reductive cleavage ...
MORISAK, Masuo, IGATA, Tomoko, YAMAMOTO, Satomi   +2 more
openaire   +3 more sources

7-Oxo-24,25-dihydrolanosterol: a novel lanosterol 14α-demethylase (P-45014) inhibitor which blocks electron transfer to the oxyferro intermediate [PDF]

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
7-Oxo-24,25-dihydrolanosterol (3 beta-hydroxy-8-lanosten-7-one, 7-oxo-HDL) was a potent competitive inhibitor for lanosterol 14 alpha-demethylase (cytochrome P-45014DM) of Saccharomyces cerevisiae. Affinity of 7-oxo-DHL for the enzyme was more than 50-times higher than those of the inherent substrates, lanosterol and 24,25-dihydrolanosterol.
Y, Aoyama, Y, Yoshida, Y, Sonoda, Y, Sato   +3 more
openaire   +2 more sources

Perturbation of sterol biosynthesis by itraconazole and ketoconazole in Leishmania mexicana mexicana infected macrophages.

, 1989
The azole antifungals ketoconazole and itraconazole possess in vitro antileishmanial activity against Leishmania mexicana mexicana amastigotes in macrophages (cell line J774G8). As in yeast and fungi, the activity is likely to be due to inhibition of the
Vanden Bossche, H, Lauwers, W J, Willemsens, G, Hart, D T, Opperdoes, Frederik   +4 more
core   +1 more source

Fitoesteroles de las partes aéreas de Ipomoea trifida (convolvulaceae)

, 2023
Objective: To isolate and identify the major phytosterols present in the plant species Ipomoea trifida through different chromatographic techniques, nuclear magnetic resonance (NMR) spectroscopic techniques and mass spectrometry (MS).
Castañeda-Gómez, Jhon F, Charry-Sánchez, Paula A, Ríos-Vásquez, Eunice, Vélez-Guzmán, Daniel F   +3 more
core   +2 more sources