Results 41 to 50 of about 736 (160)
Cancer Science, Volume 111, Issue 10, Page 3653-3664, October 2020., 2020 Cholesterol is a risk factor for breast cancer. Our study uncovers that 24‐dehydrocholesterol reductase (DHCR24), a key enzyme in the cholesterol synthesis pathway, promotes the growth of cancer stem‐like cell populations by enhancing the Hedgehog signaling pathway in ER+ and HER2+ breast cancer.
Ting Qiu +10 more
wiley +1 more source
Sterols of skin in the normal and triparanol-treated rat
Journal of Lipid Research, 1963 Skin of normal rats and of rats treated with triparanol were incubated with acetate-2-H3 for 2 hr, and the sterols were extracted and separated chromatographically.
L. Horlick, J. Avigan
doaj +1 more source
Jurnal Biota, 2019 Cancer is estimated to be the second leading cause of death globally in 2018. The background of the study was the prevalence of cancer in Indonesia in 2018 reaching 775.120 people.
Ghea Dionita Sanora +3 more
doaj +1 more source
Journal of Lipid Research, 2013 Cytochrome P450 lanosterol 14α-demethylase (CYP51) and its products, meiosis-activating sterols (MASs), were hypothesized by previous in vitro studies to have an important role in regulating meiosis and reproduction.
Rok Keber +5 more
doaj +1 more source
Journal of Lipid Research, 2019 Sterol-regulated HMG-CoA reductase (HMGCR) degradation and SREBP-2 cleavage are two major feedback regulatory mechanisms governing cholesterol biosynthesis.
Liang Chen +10 more
doaj +1 more source
Preparation and properties of a cell-free system from rat skin that catalyzes sterol biosynthesis
Journal of Lipid Research, 1966 Homogenates of epidermis from rat skin were centrifuged at 10,000 · g for 20 min. The supernatant fraction (“whole homogenate”) catalyzed the demethylation of lanosterol (C30) to yield C27-sterols. The rate of reaction was measured by the rate of release
J.L. Gaylor +3 more
doaj +1 more source
The identification of 24-methylene-24,25-dihydrolanosterol and other possible ergosterol precursors in Phycomyces blakesleeanus and Agaricus campestris [PDF]
Phytochemistry, 1975 Abstract The following sterols have been isolated from the fungi, Phycomyces blakesleeanus and Agaricus campestris : ergosterol, lanosterol, 24-methylene-24,25-dihydrolanosterol and episterol. 4,4-Dimethyl-5α-ergosta-8.24(28)-dien-3β-ol and 4α-methyl-5α-ergosta-8,24(28)-dien-3β-ol have been tentatively identified. Evidence for the incorporation of
Geoffrey Goulston +2 more
openaire +3 more sources
Frontiers in Immunology, 2018 Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interleukin-
Ryan G. Snodgrass +8 more
doaj +1 more source
The origin of fetal sterols in second-trimester amniotic fluid: endogenous synthesis or maternal-fetal transport? [PDF]
, 2012 OBJECTIVE: Cholesterol is crucial for fetal development. To gain more insight into the origin of the fetal cholesterol pool in early human pregnancy, we determined cholesterol and its precursors in the amniotic fluid of uncomplicated, singleton human ...
Plosch, Torsten; id_orcid +10 more
core +3 more sources
Analytical Study of Lanolin as Potential Biomarker of Prehistoric Sheep‐Shearing Practice
Chemistry–Methods, Volume 5, Issue 8, August 2025.Lanolin, a complex wax found on sheep wool, accumulates on shearing tools, such as flint and obsidian blades, used since the Neolithic. This study explores lanolin's degradation patterns as a potential biomarker for prehistoric sheep‐shearing practices, employing micro‐Fourier transformed infrared spectroscopy, hyperspectral imaging, and gas ...
Claudia Adsuar Fuster +8 more
wiley +1 more source