Results 51 to 60 of about 736 (160)

Effect of dietary macronutrients on intestinal cholesterol absorption and endogenous cholesterol synthesis: a randomized crossover trial

, 2021
Background and aims: Extensive research showed a diurnal rhythm of endogenous cholesterol synthesis, whereas recent research reported no diurnal rhythm of intestinal cholesterol absorption in males who consumed low-fat meals.
Smeets, E.T.H.C., Schroor, M.M., Konings, M.C.J.M., Mensink, R.P., Plat, J.   +4 more
core   +1 more source

Intracellular and Plasma Membrane Events in Cholesterol Transport and Homeostasis

Journal of Lipids, Volume 2018, Issue 1, 2018., 2018
Cholesterol transport between intracellular compartments proceeds by both energy‐ and non‐energy‐dependent processes. Energy‐dependent vesicular traffic partly contributes to cholesterol flux between endoplasmic reticulum, plasma membrane, and endocytic vesicles.
Dmitry Y. Litvinov, Eugeny V. Savushkin, Alexander D. Dergunov, Xian-Cheng Jiang   +3 more
wiley   +1 more source

Altered P450 activity associated with direct selection for fungal azole resistance [PDF]

, 1995
Azole antifungals inhibit CYP51A1-mediated sterol 14α-demethylation and the mechanism(s) of resistance to such compounds in Ustilago maydis were examined.
T. Joseph-Horne, R.S.T. Loeffler, Hollomon, D., D. Hollomon, S.L. Kelly, Kelly, S.L., Joseph-Horne, T., Loeffler, R.S.T.   +7 more
core   +1 more source

Cholesterol metabolism during ketoconazole treatment in man.

Journal of Lipid Research, 1988
Ketoconazole, an antifungal antibiotic, inhibits cholesterol synthesis by blocking demethylation of lanosterol. Effects of this inhibition were studied on serum cholesterol, lipoproteins and cholesterol precursors, biliary lipid composition, and fecal ...
T A Miettinen
doaj   +1 more source

RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol‐Triggered MET Activation

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This study elucidates the role of RNASET2 in inhibiting the metastasis of HCC. RNASET2 preferentially cleaves RNA into uridine, which contributes to the salvage synthesis of UTP and the glucuronidation of bile acids, thereby maintaining a balance in cholesterol metabolism. This process is followed by the degradation of MET in the lysosome.
Yanquan Xu, Yu Chen, Jiangang Zhang, Jingchun Wang, Shuai Yang, Huakan Zhao, Lei Wu, Juan Lei, Yu Zhou, Jin Peng, Lu Jiang, Qian Chen, Rong Xin, Jianyun Zhou, Yongsheng Li   +14 more
wiley   +1 more source

Lipidomics and anti‐trypanosomatid chemotherapy

Clinical and Translational Medicine, Volume 6, Issue 1, December 2017., 2017
Abstract BackgroundTrypanosomatids such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi belong to the order Kinetoplastida and are the source of many significant human and animal diseases. Current treatment is unsatisfactory and is compromised by the rising appearance of drug resistant parasites.
Michael Biagiotti, Sedelia Dominguez, Nader Yamout, Rachel Zufferey   +3 more
wiley   +1 more source

Lipidomics and Metabolomics Reveal Novel Mechanisms of Dyslipidemia Improvement by Dendrobium huoshanense in Mice on a High‐Fat Diet

Journal of Food Biochemistry, Volume 2025, Issue 1, 2025.
Hyperlipidemia is a direct cause of atherosclerosis and can damage the heart, brain, and kidneys, leading to coronary heart disease and cerebrovascular conditions. Dendrobium huoshanense (DH) has been demonstrated to regulate lipid metabolism. This study aimed to elucidate the mechanisms through which DH prevents lipid metabolism disorders by examining
Menghua Ma, Zongcui Yue, Chuangbo Chen, Qiyan Lin, Fucheng Zhu, Lingling Bao, Yanjun Chen, Bangxing Han, Jun Dai, Muhammad Sajid Arshad   +9 more
wiley   +1 more source

A Dietary Treatment Improves Cerebral Blood Flow and Brain Connectivity in Aging apoE4 Mice

Neural Plasticity, Volume 2016, Issue 1, 2016., 2016
APOE ε4 (apoE4) polymorphism is the main genetic determinant of sporadic Alzheimer’s disease (AD). A dietary approach (Fortasyn) including docosahexaenoic acid, eicosapentaenoic acid, uridine, choline, phospholipids, folic acid, vitamins B12, B6, C, and E, and selenium has been proposed for dietary management of AD.
Maximilian Wiesmann, Valerio Zerbi, Diane Jansen, Roy Haast, Dieter Lütjohann, Laus M. Broersen, Arend Heerschap, Amanda J. Kiliaan, Tae-Jin Kim   +8 more
wiley   +1 more source

The Potential of Isoprenoids in Adjuvant Cancer Therapy to Reduce Adverse Effects of Statins

Frontiers in Pharmacology, 2019
The mevalonate pathway provides sterols for membrane structure and nonsterol intermediates for the post-translational modification and membrane anchorage of growth-related proteins, including the Ras, Rac, and Rho GTPase family.
Huanbiao Mo, Rayna Jeter, Andrea Bachmann, Sophie T. Yount, Chwan-Li Shen, Hoda Yeganehjoo   +5 more
doaj   +1 more source

A Simulation Study of the Effects of Additive, Multiplicative, Correlated, and Uncorrelated Errors on Principal Component Analysis

Journal of Chemometrics, Volume 38, Issue 12, December 2024.
ABSTRACT Measurement errors are ubiquitous in all experimental sciences. Depending on the particular experimental platform used to acquire data, different types of errors are introduced, amounting to an admixture of additive and multiplicative error components that can be uncorrelated or correlated. In this paper, we investigate the effect of different
Edoardo Saccenti, Marieke E. Timmerman, José Camacho   +2 more
wiley   +1 more source