Results 31 to 40 of about 736 (160)

FoxO4 interacts with the sterol regulatory factor SREBP2 and the hypoxia inducible factor HIF2α at the CYP51 promoter

Journal of Lipid Research, 2014
The late steps of cholesterol biosynthesis are oxygen demanding, requiring eleven oxygen molecules per synthesized cholesterol molecule. A key enzymatic reaction, which occurs at the top of the Bloch and Kandutsch-Russell pathways, is the demethylation ...
Jun Zhu, Xiangning Jiang, Farid F. Chehab   +2 more
doaj   +1 more source

Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake

Journal of Lipid Research, 2010
The Forkhead transcription factors FoxO1, FoxO3a, and FoxO4 play a prominent role in regulating cell survival and cell cycle. Whereas FOXO1 was shown to mediate insulin sensitivity and adipocyte differentiation, the role of the transcription factor FoxO4
Jun Zhu, Khalid Mounzih, Eric F. Chehab, Nico Mitro, Enrique Saez, Farid F. Chehab   +5 more
doaj   +1 more source

Isolation and identification of new constituents in milk fat

Journal of Lipid Research, 1970
After removal of cholesterol on a digitonin column, the unsaponifiable matter of milk fat was examined for alcoholic substituents. Derivatization with pyruvic acid chloride 2,6-dinitrophenylhydrazone and fractionation of the derivatives gave four main ...
C.R. Brewington, E.A. Caress, D.P. Schwartz   +2 more
doaj   +1 more source

Aspergillus oryzaeproduces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol [PDF]

FEMS Microbiology Letters, 2005
The formation of cholesterol synthesis inhibiting molecules by five different strains of the koji mold Aspergillus oryzae was studied. After growing these strains on a complex liquid medium we found in crude organic phase extracts and specific fractions there from compounds inhibiting cholesterol synthesis in human hepatic T9A4 cells in vitro at enzyme
Hassan, Hajjaj, Philippe, Duboc, Laurent B, Fay, Irène, Zbinden, Katherine, Macé, Peter, Niederberger   +5 more
openaire   +2 more sources

Molecular diversity of sterol 14α-demethylase substrates in plants, fungi and humans [PDF]

, 1998
Metabolism of lanosterol (LAN), 24-methylene-24,25-dihydrolanosterol (24-methyleneDHL), dihydrolanosterol (DHL) and obtusifoliol (OBT) by purified human, plant (Sorghum bicolor) and fungal (Candida albicans) sterol 14α-demethylase (CYP51; P45014DM ...
Lamb, David C, Kelly, Diane E, Steven L Kelly, David C Lamb, Diane E Kelly, Kelly, Steven L   +5 more
core   +1 more source

Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.

Journal of Lipid Research, 1991
Lanosterol 14 alpha-demethylase (P45014DM) is the cytochrome P450 enzyme complex responsible for an early step in cholesterol biosynthesis, namely the 14 alpha-demethylation of lanosterol.
SF Tuck, H Patel, E Safi, CH Robinson
doaj   +1 more source

Sterol content of the Myxomycetes Physarum polycephalum and P. flavicomum

Journal of Lipid Research, 1976
The sterol content of two Myxomycetes, Physarum polycephalum and P. flavicomum has been examined. The sterols of the two species are apparently identical, the two major sterols in each being poriferasterol and 22-dihydroporiferasterol.
E Bullock, C J Dawson
doaj   +1 more source

Inhibitors of sterol synthesis. Submicromolar 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol causes a major modification of the sterol composition of CHO-K1 cells and a marked change in cell morphology.

Journal of Lipid Research, 1994
Incubation of Chinese hamster ovary cells (CHO-K1) with 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol (0.1 microM) in lipid-deficient medium led to a major change in cellular sterol composition, which was characterized by a very marked ...
A Izumi, F.D Pinkerton, S.O Nelson, J.S Pyrek, P.J Neill, J H Smith, G.J Schroepfer, Jr   +6 more
doaj   +1 more source

Dependence between sterols synthesis and the method of beer yeast oxygenation [PDF]

Техника и технология пищевых производств, 2018
Oxygen is necessary for yeast to synthesize membrane components (unsaturated fatty acids and sterols), but its high content in the medium during fermentation increases the concentration of cell oxidative metabolism products.
Permyakova L.
doaj   +1 more source

Oxidative demethylation of lanosterol in cholesterol biosynthesis: accumulation of sterol intermediates.

Journal of Lipid Research, 1986
With [3H-24,25]-dihydrolanosterol as substrate, large-scale metabolic formation of intermediates of lanosterol demethylation was carried out to identify all compounds in the metabolic process.
A Shafiee, J M Trzaskos, Y K Paik, J L Gaylor   +3 more
doaj   +1 more source