Results 11 to 20 of about 736 (160)
Chemical and Pharmaceutical Bulletin, 1982 The metabolism of 27-nor-24, 25-dihydrolanosterol (1) which is an effective inhibitor of cholesterol biosynthesis from lanosterol was studied using the unlabeled and 24, 25-tritiated compounds. 1 was transformed into the cholesterol analog, 27-norcholesterol, to the extent of 6.5% by incubation with rat liver homogenate under conditions such that ...
SATO, YOSHIHIRO, SONODA, YOSHIKO
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Hypolipidemic effects of dietary 7-oxo-24,25-dihydrolanosterol. [PDF]
Journal of Pharmacobio-Dynamics, 1985 7-Oxo-24,25-dihydrolanosterol (7-oxo-DHL), an inhibitor of cholesterol biosynthesis from lanosterol in vitro, lowered the serum total-cholesterol and triglyceride at a level of 0.1% in a diet on male Wistar rats. This effect was slightly lower than that of clofibrate (CF) which was examined as a reference.
SONODA, YOSHIKO, SATO, YOSHIHIRO
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SeparationsThe Analytical Quality by Design (AQbD) concept was adopted to establish a quantitative analysis of multi-components with a single marker (QAMS) method for industrial lanolin alcohol, targeting cholesterol, lanosterol, and 24,25-dihydrolanosterol.
Kaidierya Abudureheman +3 more
doaj +2 more sources
Oxygenated sterols as inhibitors of enzymatic conversion of dihydrolanosterol into cholesterol. [PDF]
Chemical and Pharmaceutical Bulletin, 1984 Seven oxygenated sterols were tested for their effect on cholesterol biosynthesis from 24, 25-dihydrolanosterol by rat hepatic subcellular 10000 x g supernatant fraction. The sterols (40 μM) exhibited considerable inhibitory effects on the synthesis of cholesterol from [24, 25-3H]-24, 25-dihydrolanosterol (18 μM).
Sato, Yoshihiro +3 more
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In vitro effects of oxygenated lanosterol derivatives on cholesterol biosynthesis from 24,25-dihydrolanosterol. [PDF]
Chemical and Pharmaceutical Bulletin, 1988 The effects of oxygenated lanosterol derivatives (1-27, 5μM) including 32-oxygenated lanosterol derivatives on cholesterol biosyntheiss from [24, 25-3H2]-24, 25-dihydrolanosterol (18μM) were tested in 10000×g supernatant (S-10) fraction of rat liver homogenate.
SONODA, YOSHIKO +2 more
core +6 more sources
Solanum alkaloids as inhibitors of enzymatic conversion of dihydrolanosterol into cholesterol. [PDF]
Chemical and Pharmaceutical Bulletin, 1987 The effects of several solanum steroidal alkaloids on cholesterol biosynthesis from 24, 25- dihydrolanosterol by 10000 × g supernatant fluid of rat liver were examined. Solacongestidine (I), solafloridine (II) and solasodine (III) (40 μM each) exhibited considerable inhibitory effects (59, 51, 37% inhibition, respectively) on the synthesis of ...
KUSANO, GENJIRO +4 more
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Chemical and Pharmaceutical Bulletin, 1989 27-Nor-24,25-dihydrolanosterol (27-nor-DHL), 26,27-dinor-24,25- dihydrolanosterol (26,27-dinor-DHL), and 25,26,27-trinor-24,25-dihydrolanosterol (25,26,27-trinor-DHL), analogs of 24,25-dihydrolanosterol (DHL) which have no C-27 carbon, C-26,27 carbons and C-25,26,27 carbons, were converted to the corresponding 14-demethylated products using a ...
SONODA, Yoshiko +2 more
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Squalene through Its Post-Squalene Metabolites Is a Modulator of Hepatic Transcriptome in Rabbits. [PDF]
Int J Mol Sci, 2022 Squalene is a natural bioactive triterpene and an important intermediate in the biosynthesis of sterols. To assess the effect of this compound on the hepatic transcriptome, RNA-sequencing was carried out in two groups of male New Zealand rabbits fed ...
Abuobeid R +10 more
europepmc +3 more sources
Serum 4β-hydroxycholesterol increases during fluconazole treatment. [PDF]
Eur J Clin Pharmacol, 2021 S.659-669Purpose The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4v-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity.
Lütjohann D +4 more
europepmc +3 more sources
Roles of Ferric Peroxide Anion Intermediates (Fe3+O2 -, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model. [PDF]
Angew Chem Int Ed EnglAlthough most cytochrome P450‐catalyzed oxidations are believed to utilize perferryl oxygen (Compound I) as a reactive iron species, the ferric peroxide species (Compound 0) is thought to catalyze some oxidative deformylations. This study revealed the dominant contribution of Compound 0 in the P450 19A1‐catalyzed steroid aromatization and P450 2B4 ...
Tateishi Y +4 more
europepmc +2 more sources