Results 41 to 50 of about 9,730 (212)

E. coli Dihydroorotate Dehydrogenase Reveals Structural and Functional Distinctions between Different Classes of Dihydroorotate Dehydrogenases [PDF]

Structure, 2002
The flavoenzymes dihydroorotate dehydrogenases (DHODs) catalyze the fourth and only redox step in the de novo biosynthesis of UMP. Enzymes belonging to class 2, according to their amino acid sequence, are characterized by having a serine residue as the catalytic base and a longer N terminus. The structure of class 2 E.
Nørager, Sofie, Jensen, Kaj Frank, Björnberg, Olof, Larsen, Sine   +3 more
openaire   +3 more sources

Host reticulocytes provide metabolic reservoirs that can be exploited by malaria parasites [PDF]

, 2015
Human malaria parasites proliferate in different erythroid cell types during infection. Whilst Plasmodium vivax exhibits a strong preference for immature reticulocytes, the more pathogenic P. falciparum primarily infects mature erythrocytes.
Barrett, Michael P., Creek, Darren J., De Souza, David, Evans, Krystal J., McConville, Malcolm J., Muller, Sylke, Schofield, Louis, Srivastava, Anubhav, Waters, Andrew P.   +8 more
core   +1 more source

Histone deacetylase inhibitors: A new mode for inhibition of cholesterol metabolism [PDF]

, 2008
Background Eukaryotic gene expression is a complex process involving multiple cis and trans activating molecules to either facilitate or inhibit transcription.
Sridar V Chittur, Niquiche Sangster-Guity, Paulette J McCormick   +2 more
core   +1 more source

Evaluation of Antigens for Development of a Serological Test for Human African Trypanosomiasis [PDF]

, 2016
BACKGROUND: Control and elimination of human African trypanosomiasis (HAT) can be accelerated through the use of diagnostic tests that are more accurate and easier to deploy.
Albertini, A, Bangs, J, Barrett, MP, Bishop, R, Biéler, S, Büscher, P, Carrington, M, Ferguson, M, McCulloch, R, McKerrow, J, Michel, G, Michels, PA, Mottram, JC, Ndung'u, JM, Nerima, B, Phillips, MA, Radwandska, M, Robinson, DR, Sanchez, J-C, Schwaeble, W, Waltenberger, H   +20 more
core   +19 more sources

SOX2-dependent expression of dihydroorotate dehydrogenase regulates oral squamous cell carcinoma cell proliferation

International Journal of Oral Science, 2021
Summary Oral squamous cell carcinoma (OSCC) become a heavy burden of public health, with approximately 300 000 newly diagnosed cases and 145 000 deaths worldwide per year.
Xuemei Qiu, Sheng Jiang, Yanxuan Xiao, Yumin He, Tao Ren, Lu Jiang, Rui Liu, Qianming Chen   +7 more
doaj   +1 more source

Pyrimidine biosynthesis is not an essential function for trypanosoma brucei bloodstream forms [PDF]

, 2013
<p>Background: African trypanosomes are capable of both pyrimidine biosynthesis and salvage of preformed pyrimidines from the host, but it is unknown whether either process is essential to the parasite.</p> <p>Methodology/Principal ...
A Hofer, Anne Donachie, B Aronow, B Rodenko, BA Fox, Ben L. Kelly, CC Wang, D Bi, Daniel N. A. Tagoe, DB Longley, DJ Hammond, ET Larson, G Gao, G Priotto, H Hirumi, Harry P. de Koning, HF Hassan, HMS Ibrahim, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, HP De Koning, IG Papageorgiou, JA Ali, Jane C. Munday, JB French, Juma A. M. Ali, K Van Dyke, KL Martin, Liam J. Morrison, LJ Wallace, M Balasegaram, M Berg, M Berg, MD Scahill, MI Al-Salabi, MJ Natto, MK Gould, N Sienkiewicz, N Sternberg, PI Fields, R Brun, R Brun, S Gudin, S Lillico, SM Landfear, TL Arakaki, V Bellofatto, VM Castillo-Acosta, ZN Wilson   +51 more
core   +4 more sources

Peripheral Membrane Proteins: Promising Therapeutic Targets across Domains of Life

Membranes, 2021
Membrane proteins can be classified into two main categories—integral and peripheral membrane proteins—depending on the nature of their membrane interaction.
Deborah M. Boes, Albert Godoy-Hernandez, Duncan G. G. McMillan   +2 more
doaj   +1 more source

A double‐blind, randomized, placebo‐controlled phase 2 trial evaluating the selective dihydroorotate dehydrogenase inhibitor vidofludimus calcium in relapsing‐remitting multiple sclerosis

Annals of Clinical and Translational Neurology, 2022
Objective Inhibition of dihydroorotate dehydrogenase suppresses magnetic resonance imaging brain lesions and disease activity in multiple sclerosis but has limiting tolerability.
Robert J. Fox, Heinz Wiendl, Christian Wolf, Nicola De Stefano, Johann Sellner, Viktoriia Gryb, Konrad Rejdak, Plamen Stoyanov Bozhinov, Nataliya Tomakh, Iryna Skrypchenko, Andreas R. Muehler   +10 more
doaj   +1 more source

Respiratory electron transfer pathways in plant mitochondria [PDF]

, 2014
The respiratory electron transport chain (ETC) couples electron transfer from organic substrates onto molecular oxygen with proton translocation across the inner mitochondrial membrane.
Braun, Hans-Peter, Schertl, Peter
core   +4 more sources

Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Zhongliu Fangzhi Yanjiu
Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism.
CHE Xin, HU Zhen, WANG Yonggang, LI Yaoping   +3 more
doaj   +1 more source