Selective cytotoxicity of dihydroorotate dehydrogenase inhibitors to human cancer cells under hypoxia and nutrient-deprived conditions [PDF]
, 2018 Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. It is located on the mitochondrial inner membrane and contributes to the respiratory chain by shuttling electrons to the ubiquinone pool.
Amalia, Eri +11 more
core +3 more sources
Tackling resistance: Emerging antimalarials and new parasite targets in the era of elimination [version 1; referees: 2 approved] [PDF]
, 2018 Malaria remains a significant contributor to global human mortality, and roughly half the world’s population is at risk for infection with Plasmodium spp. parasites.
Matthews, Emily S, Odom John, Audrey R
core +2 more sources
Scientific African, 2023 Malaria continues to be a major public health concern, particularly for children and pregnant women in areas where the disease is endemic. Developing safe and efficient antimalarial therapies to fight the disease is essential.
Sherif Hamidu +11 more
doaj +1 more source
Comparison of the susceptibility of Plasmodium knowlesi and Plasmodium falciparum to antimalarial agents. [PDF]
, 2017 BACKGROUND: The simian malaria parasite Plasmodium knowlesi is now a well-recognized pathogen of humans in South-East Asia. Clinical infections appear adequately treated with existing drug regimens, but the evidence base for this practice remains weak ...
Blasco, Benjamin +3 more
core +1 more source
Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]
, 2006 The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial ...
Abdul +39 more
core +4 more sources
Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways
Metabolites, 2022 Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms.
Hélène Lemieux, Pierre U. Blier
doaj +1 more source
The use of macroarray as a simple tool to follow the metabolic profile of Lactobacillus plantarum during fermentation [PDF]
, 2014 201
Ahola, Virpi +4 more
core +1 more source
The antilymphocytic activity of brequinar sodium and its potentiation by cytidine: Effects on lymphocyte proliferation and cytokine production [PDF]
, 1993 Based on its capacity to inhibit de novo pyrimidine biosynthesis by blocking dihydroorotate dehydrogenase activity, the antitumor agent brequinar sodium (BQR) has emerged as a new immunosuppressive agent.
Lemster, B +4 more
core +1 more source
Synthesis and in vitro evaluation of hydrazinyl phthalazines against malaria parasite, Plasmodium falciparum. [PDF]
, 2016 In this report, we describe the synthesis of 1-(Phthalazin-4-yl)-hydrazine using bronsted acidic ionic liquids and demonstrate their ability to inhibit asexual stage development of human malaria parasite, Plasmodium falciparum.
Anusha, S. +7 more
core +1 more source
CodY, a pleiotropic regulator, influences multicellular behaviour and efficient production of virulence factors in Bacillus cereus [PDF]
, 2012 In response to nutrient limitation in the environment, the global transcriptional regulator CodY modulates various pathways in low G+C Gram-positive bacteria.
Basset, Coraline +6 more
core +3 more sources