Results 11 to 20 of about 9,730 (212)

Dihydroorotate dehydrogenase inhibitors in anti-infective drug research [PDF]

European Journal of Medicinal Chemistry, 2019
Pyrimidines are essential for the cell survival and proliferation of living parasitic organisms, such as Helicobacter pylori, Plasmodium falciparum and Schistosoma mansoni, that are able to impact upon human health. Pyrimidine building blocks, in human cells, are synthesised via both de novo biosynthesis and salvage pathways, the latter of which is an ...
Boschi D., Pippione A. C., Sainas S., Lolli M. L.   +3 more
openaire   +5 more sources

Targeting dihydroorotate dehydrogenase in acute myeloid leukemia

Haematologica, 2018
Zhihong Zeng, Marina Konopleva
doaj   +4 more sources

Unveiling the Antiviral Capabilities of Targeting Human Dihydroorotate Dehydrogenase against SARS-CoV‑2 [PDF]

ACS Omega
Aline D. Purificação, Sabrina Silva-Mendonça, Luiza V. Cruz, Carolina Q. Sacramento, Jairo R. Temerozo, Natalia Fintelman-Rodrigues, Caroline Souza de Freitas, Bruna Fleck Godoi, Miguel Menezes Vaidergorn, Juliana Almeida Leite, Luis Carlos Salazar Alvarez, Murillo V. Freitas, Meryck F. B. Silvac, Bianca A. Martin, Renata F. V. Lopez, Bruno J. Neves, Fabio T. M. Costa, Thiago M. L. Souza, Flavio da Silva Emery, Carolina Horta Andrade, M. Cristina Nonato   +20 more
doaj   +2 more sources

New Insights into rice pyrimidine catabolic enzymes

Frontiers in Plant Science, 2023
IntroductionRice is a primary global food source, and its production is affected by abiotic stress, caused by climate change and other factors. Recently, the pyrimidine reductive catabolic pathway, catalyzed by dihydropyrimidine dehydrogenase (DHPD ...
Andrea J. Lopez, Heidy Y. Narvaez-Ortiz, Maria A. Rincon-Benavides, Dania Camila Pulido, Luis Eduardo Fuentes Suarez, Barbara H. Zimmermann   +5 more
doaj   +1 more source

Ferroptosis plays a novel role in nonalcoholic steatohepatitis pathogenesis

Frontiers in Pharmacology, 2022
Ferroptosis relies on iron, and ferroptotic cell death is triggered when the balance of the oxidation-reduction system is disrupted by excessive lipid peroxide accumulation. A close relationship between ferroptosis and nonalcoholic steatohepatitis (NASH)
Fei Xiong, Qiao Zhou, Xiaobo Huang, Peng Cao, Yi Wang   +4 more
doaj   +1 more source

Recent approaches in the drug research and development of novel antimalarial drugs with new targets

Acta Pharmaceutica, 2023
Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment ...
Chinnappanna Naveen Kumar Reddy, Yennam Gopi, Chaitanya Chaitanya Budagam Haima Naga Venkata, Pottathil Shinu, Borah Pobitra, Venugopala Katharigatta N., Deb Pran Kishore, Mailavaram Raghu Prasad   +7 more
doaj   +1 more source

Regioselective Synthesis of 5- and 3-Hydroxy-N-Aryl-1H-Pyrazole-4-Carboxylates and Their Evaluation as Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

Molecules, 2022
In silico evaluation of various regioisomeric 5- and 3-hydroxy-substituted alkyl 1-aryl-1H-pyrazole-4-carboxylates and their acyclic precursors yielded promising results with respect to their binding in the active site of dihydroorotate dehydrogenase of ...
Luka Vah, Tadej Medved, Uroš Grošelj, Marina Klemenčič, Črtomir Podlipnik, Bogdan Štefane, Jernej Wagger, Marko Novinec, Jurij Svete   +8 more
doaj   +1 more source

Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

eLife, 2023
Drug resistance remains a major obstacle to malaria control and eradication efforts, necessitating the development of novel therapeutic strategies to treat this disease.
Rebecca EK Mandt, Madeline R Luth, Mark A Tye, Ralph Mazitschek, Sabine Ottilie, Elizabeth A Winzeler, Maria Jose Lafuente-Monasterio, Francisco Javier Gamo, Dyann F Wirth, Amanda K Lukens   +9 more
doaj   +1 more source

Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family. [PDF]

, 2015
BackgroundIt is now recognized that enzymatic or chemical side-reactions can convert normal metabolites to useless or toxic ones and that a suite of enzymes exists to mitigate such metabolite damage.
Cooper, Arthur JL, Downs, Diana M, ElBadawi-Sidhu, Mona, Fiehn, Oliver, Gerdes, Svetlana, Hanson, Andrew D, Hodge-Hanson, Kelsey, Niehaus, Thomas D, Zhukov, Aleksey   +8 more
core   +4 more sources

Correction: Vidofludimus inhibits porcine reproductive and respiratory syndrome virus infection by targeting dihydroorotate dehydrogenase [PDF]

Veterinary Research
Yuanqi Yang, Yanni Gao, Lujie Zhang, Xing Liu, Yangyang Sun, Juan Bai, Ping Jiang   +6 more
doaj   +2 more sources