Redistribution of defective mitochondria-mediated dihydroorotate dehydrogenase imparts 5-fluorouracil resistance in colorectal cancer [PDF]
Redox BiologyAlthough 5-fluorouracil (5-FU) is the primary chemotherapy treatment for colorectal cancer (CRC), its efficacy is limited by drug resistance. Ferroptosis activation is a promising treatment for 5-FU-resistant cancer cells; however, potential therapeutic ...
Shuohui Dong +16 more
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Dihydroorotate Dehydrogenase in Mitochondrial Ferroptosis and Cancer Therapy [PDF]
CellsFerroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation. Since the identification of dihydroorotate dehydrogenase (DHODH) as a mitochondrial suppressor of ferroptosis in 2021, increasing evidence has highlighted its ...
Jaewang Lee, Jong-Lyel Roh
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Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia [PDF]
Cell Death and Disease, 2022 The development of different generations of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has led to the high overall survival of chronic myeloid leukemia (CML) patients.
Mohammad Houshmand +25 more
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Vidofludimus inhibits porcine reproductive and respiratory syndrome virus infection by targeting dihydroorotate dehydrogenase [PDF]
Veterinary Research, 2023 Porcine reproductive and respiratory syndrome virus (PRRSV) infection has caused huge economic losses in global swine industry over the last 37 years. PRRSV commercial vaccines are not effective against all epidemic PRRSV strains.
Yuanqi Yang +6 more
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Identification of Human Dihydroorotate Dehydrogenase Inhibitor by a Pharmacophore-Based Virtual Screening Study [PDF]
Molecules, 2022 Human dihydroorotate dehydrogenase (hDHODH) is an enzyme belonging to a flavin mononucleotide (FMN)-dependent family involved in de novo pyrimidine biosynthesis, a key biological pathway for highly proliferating cancer cells and pathogens.
Salvatore Galati +7 more
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Structure-Based Screening of Deep-Sea Microbial Metabolites Against Plasmodium falciparum Dihydroorotate Dehydrogenase [PDF]
BiologyMalaria is a major global health concern caused by Plasmodium parasites, among which Plasmodium falciparum is responsible for the most severe and fatal cases.
Avtar Singh +2 more
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NK-A 17E-233I: a novel competitive inhibitor of human dihydroorotate dehydrogenase (DHODH) for cancer therapy [PDF]
Journal of Experimental & Clinical Cancer ResearchHuman dihydroorotate dehydrogenase (DHODH) is the rate-limiting enzyme in pyrimidine de novo synthesis and represents a promising target for cancer therapy.
Mohammed Moustapha Anwar +15 more
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Identification of novel dihydroorotate dehydrogenase (DHODH) inhibitors for cancer: computational drug repurposing strategy [PDF]
BMC Pharmacology and ToxicologyBackground Dihydroorotate dehydrogenase (DHODH) is a crucial enzyme in de novo pyrimidine production, initially sought since its disruption is frequently observed in malignancies.
Rahamathtunnisa Rajamohamed +1 more
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Translational Pharmacokinetic-Pharmacodynamic Modeling of a Novel Oral Dihydroorotate Dehydrogenase (DHODH) Inhibitor, HOSU-53 (JBZ-001) [PDF]
PharmaceuticsBackground: HOSU-53 (JBZ-001), an orally bioavailable new chemical entity, represents a highly potent dihydroorotate dehydrogenase (DHODH) inhibitor in late preclinical development for application in cancer therapy.
Joo Young Na +6 more
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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase [PDF]
Protein & Cell, 2020 Yechun Xu, Hualiang Jiang
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