Results 21 to 30 of about 9,730 (212)

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

Haematologica, 2018
Acute myeloid leukemia is a disorder characterized by abnormal differentiation of myeloid cells and a clonal proliferation derived from primitive hematopoietic stem cells.
Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Weiqiang Lu, Jin Huang   +13 more
doaj   +1 more source

Identifcation of small molecule enzyme inhibitors as broad-spectrum anthelmintics [PDF]

, 2019
Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites.
Aroian, Raffi V., Brindley, Paul J., Bulman, Christina A., Elfawal, Mostafa A., Helander, Jon, Janetka, James W., Mitreva, Makedonka, Rosa, Bruce A., Sakanari, Judy, Tyagi, Rahul, Wildman, Scott A.   +10 more
core   +3 more sources

Stereospecificity of the Dihydroorotate‐Dehydrogenase Reaction [PDF]

European Journal of Biochemistry, 1972
Dihydroorotate dehydrogenase from Zymobacterium oroticum is shown to catalyse the anti‐elimination of hydrogen from the substrate. In the presence of a catalytic amount of NAD+ the enzyme catalyses the exchange between the abstractable hydrogen atoms of dihydroorotate and solvent protons, the exchange of (5S)‐H atom being twice as fast as that of the
P, Blattmann, J, Rétey
openaire   +5 more sources

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Haematologica, 2019
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid ...
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng   +13 more
doaj   +1 more source

Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. [PDF]

PLoS ONE, 2014
Human dihydroorotate dehydrogenase (hDHODH) is a class-2 dihydroorotate dehydrogenase. Because it is extensively used by proliferating cells, its inhibition in autoimmune and inflammatory diseases, cancers, and multiple sclerosis is of substantial ...
Kuei-Chung Shih, Chi-Ching Lee, Chi-Neu Tsai, Yu-Shan Lin, Chuan-Yi Tang   +4 more
doaj   +1 more source

Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection. [PDF]

Eur J Clin Invest, 2020
Coelho AR, Oliveira PJ.
europepmc   +4 more sources

Synthesis, Design, and Structure–Activity Relationship of the Pyrimidone Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

Molecules, 2018
The inhibition of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) potentially represents a new treatment option for malaria, as P. falciparum relies entirely on a de novo pyrimidine biosynthetic pathway for survival.
Le Xu, Wenjie Li, Yanyan Diao, Hongxia Sun, Honglin Li, Lili Zhu, Hongchang Zhou, Zhenjiang Zhao   +7 more
doaj   +1 more source

Enzymhistochemischer Nachweis der Dihydroorotat-Dehydrogenase/ Oxidase in verschiedenen Säugerorganen [PDF]

, 2005
Enzymhistochemischer Nachweis der Dihydroorotat-Dehydrogenase/ Oxidase in verschiedenen ...
Becker-Hintermeier, Cornelia, Löffler, M. (Prof. Dr.)   +1 more
core   +1 more source

In-silico Leishmania Target Selectivity of Antiparasitic Terpenoids

Molecules, 2013
Neglected Tropical Diseases (NTDs), like leishmaniasis, are major causes of mortality in resource-limited countries. The mortality associated with these diseases is largely due to fragile healthcare systems, lack of access to medicines, and resistance by
Ifedayo Victor Ogungbe, William N. Setzer   +1 more
doaj   +1 more source

Inhibitors of Nucleotide Biosynthesis as Candidates for a Wide Spectrum of Antiviral Chemotherapy

Microorganisms, 2022
Emerging and re-emerging viruses have been a challenge in public health in recent decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved in virus multiplication represent an interesting strategy to combat viruses ...
Claudia Soledad Sepúlveda, Cybele Carina García, Elsa Beatriz Damonte   +2 more
doaj   +1 more source