Results 71 to 80 of about 9,730 (212)

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

Identification of novel Plasmodium falciparum dihydroorotate dehydrogenase inhibitors for malaria using in silico studies

Scientific African, 2022
Malaria, that ancient infectious disease is considered a great health problem due to its highly infectious and mortality rates. The more harmful kind of malaria is Plasmodium falciparum (Pf), accounting for over 1M fatalities yearly; unfortunately ...
Abdulrahim A. Alzain, PhD, Zain Alsharf M. Ahmed, Mariam A. Mahadi, Elaf A khairy, Fatima A. Elbadwi   +4 more
doaj   +1 more source

Chemical control strategies for Poa annua in managed turfgrass systems

Crop, Forage &Turfgrass Management, Volume 12, Issue 1, June 2026.
Abstract Poa annua L. is a widespread and persistent weed in managed turfgrass systems, exhibiting both annual and short‐lived perennial growth habits. Effective management requires an integrated approach, with chemical herbicides remaining a primary tool.
James D. McCurdy, Rebecca G. Bowling, Aaron J. Patton, Edicarlos B. de Castro, James T. Brosnan, David E. Ervin, Shawn D. Askew, Clebson G. Gonçalves, Matthew T. Elmore, J. Scott McElroy, Brandon C. McNally, Benjamin D. Pritchard, John E. Kaminski, Travis W. Gannon, J. Bryan Unruh, Muthukumar V. Bagavathiannan   +15 more
wiley   +1 more source

Cytosolic enzymes with a mitochondrial ancestry from the anaerobic chytrid Piromyces sp. E2 [PDF]

, 1998
The anaerobic chytrid Piromyces sp. E2 lacks mitochondria, but contains hydrogen-producing organelles, the hydrogenosomes. We are interested in how the adaptation to anaerobiosis influenced enzyme compartmentalization in this organism.
Akhmanova, A.S. (Anna), Hackstein, J.H.P. (Johannes), Harhangi, B.S. (Biswadjiet), Hosea, K.M. (Ken), Vogels, G.D. (Godfried), Voncken, J.W. (Jan Willem)   +5 more
core   +1 more source

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, Volume 13, Issue 26, 8 May 2026.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

Tetflupyrolimet shows selectivity for plant dihydroorotate dehydrogenase over Aspergillus orthologs

Scientific Reports
Shared enzymatic targets between azoles used in agriculture as fungicides and clinical antifungals are hypothesized to have led to the drift of resistant fungal isolates from field to clinic, reducing efficacy of azoles in infectious disease treatment ...
Sang-Ic Kim, Venkataphanikanth Turlapati, Bhavna Agashe, Qun Lu, Sriram Satagopan, James A. Sweigard, Ryan P. Emptage   +6 more
doaj   +1 more source

Active Compound from An Indonesian Endophytic Fungus Talaromyces veruculosus BioMCC-f.EP.2165 Inhibiting Plasmodium falciparum Dihydroorotate Dehydrogenase as Antimalarial Agent [PDF]

BIO Web of Conferences
An Indonesian endophytic fungus Talaromyces veruculosus BioMCC-f.EP.2165, was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
Nugroho Nuki Bambang, Pramisandi Amila, Siska Eka, Chrisnayanti Evita, Hidayati Dyah Noor, Suryani Suryani, Nurlaila Nurlaila, Waluyo Danang, Prabandari Erwahyuni Endang, Nozaki Tomoyoshi   +9 more
doaj   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Ubiquitin‐Specific Protease 45 Inhibits Lung Adenocarcinoma Ferroptosis by Regulating Ubiquitination and Stability of Glutathione Peroxidase 4

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Lung adenocarcinoma is the most common subtype of lung cancer and the leading cause of cancer‐related mortality worldwide. Ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation, has emerged as a promising therapeutic target for lung adenocarcinoma.
Mingxiang Huang, Meilan Fang, Yao Wang, Shanshan Liu, Fengqin Li   +4 more
wiley   +1 more source