Results 81 to 90 of about 9,730 (212)

DHODH Alleviates Heart Failure via the Modulation of CoQ-Related Ferroptotic Inhibition

Frontiers in Bioscience-Landmark
Background: Heart failure (HF) is a clinical syndrome that seriously endangers human health and quality of life as the terminal stage of cardiovascular diseases.
Chen Wang, Chuchu Chen, Jiabin Zhou, Jiayu Shi, Hanrui Sun, Jingyu Li, Pengyang Gu, Xinglin Wang, Qi Lu, Shuai Wang   +9 more
doaj   +1 more source

CO2-Induced Transcriptional Reorganization: Molecular Basis of Capnophillic Lactic Fermentation in Thermotoga neapolitana [PDF]

, 2020
Capnophilic lactic fermentation (CLF) is a novel anaplerotic pathway able to convert sugars to lactic acid (LA) and hydrogen using CO2 as carbon enhancer in the hyperthermophilic bacterium Thermotoga neapolitana.
Dipasquale, Laura, d’Ippolito, Giuliana, ESERCIZIO, NUNZIA, Fontana, Angelo, LANDI, SIMONE, Lanzilli, Mariamichella, Pradhan, Nirakar, VASTANO, MARCO   +7 more
core   +2 more sources

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Prenylcysteine Oxidase 1 Deficiency Protects the Cardiac Muscle Cell Line HL‐1 Against Ischaemic/Hypoxic Stress

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Ischaemic/hypoxic stress leads to heart remodeling and dysfunction. PCYOX1 promotes cardiomyocyte survival during injury, reducing the generation of reactive oxygen species. PCYOX1 deficiency regulates key proteins to preserve cardiomyocyte structure and function such as creatine kinase.
Cristina Banfi, Lisa Brocca, Alice Bascucci, Giulia Giusy Papaianni, Alice Mallia, Sonia Eligini   +5 more
wiley   +1 more source

Plasmodium falciparum  heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers [PDF]

, 2012
One-fourth of Plasmodium falciparum proteins have asparagine repeats that increase the propensity for aggregation, especially at elevated temperatures that occur routinely in malaria-infected patients.
Goldberg, Daniel E, Lindquist, Susan, Muralidharan, Vasant, Oksman, Anna, Pal, Priya   +4 more
core   +2 more sources

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

Viruses, 2020
Mammarenaviruses cause chronic infections in rodents, which are their predominant natural hosts. Human infection with some of these viruses causes high-consequence disease, posing significant issues in public health.
Yu-Jin Kim, Beatrice Cubitt, Yingyun Cai, Jens H. Kuhn, Daniel Vitt, Hella Kohlhof, Juan C. de la Torre   +6 more
doaj   +1 more source

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, Volume 13, Issue 22, 17 April 2026.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Gut microbial features can predict host phenotype response to protein deficiency. [PDF]

, 2018
Malnutrition remains a major health problem in low- and middle-income countries. During low protein intake, <0.67 g/kg/day, there is a loss of nitrogen (N2 ) balance, due to the unavailability of amino acid for metabolism and unbalanced protein ...
Dugas, Lara R, Forrester, Terrence, Gilbert, Jack A, Layden, Brian T, Navarro, Guadalupe, Sharma, Anukriti   +5 more
core  

Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation

Advanced Science, Volume 13, Issue 23, 23 April 2026.
The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley   +1 more source