Results 91 to 100 of about 9,730 (212)
Multiple sclerosis: Immunopathology and treatment update [PDF]
, 2017 The treatment of multiple sclerosis (MS) has changed over the last 20 years. All immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a medical challenge in MS to develop a treatment for progressive forms.
Bielekova +9 more
core +2 more sources
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.In an organotypic cerebellar slice culture (OSC) ex vivo demyelination model, teriflunomide has been shown to positively affect myelin preservation during demyelination and enhance remyelination. This is hypothesized as being achieved by modulating the dynamics of glial cells.
Jessica Kronenberg +8 more
wiley +1 more source
The mechanisms of Fenretinide-mediated anti-cancer activity and prevention of obesity and type-2 diabetes [PDF]
, 2014 Copyright © 2014. Published by Elsevier Inc. Acknowledgments This work was supported by the British Heart Foundation Intermediate Basic Research Fellowship FS/09/026/27398 to N.M.
McIlroy, George David, Mody, Nimesh
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.This registry‐based analysis of 1183 MS clinical trials (2004–2024) shows sustained global activity and a marked increase in mainland China after 2018, predominantly driven by late‐phase and bioequivalence studies. Trial density varied across regions, and IFNAR, CD20, and S1PR1 were the most frequently investigated targets. ABSTRACT Background Multiple
Chaoyang Chen +7 more
wiley +1 more source
, 2019 The aging process includes impairment in mitochondrial function, a reduction in anti-oxidant activity, and an increase in oxidative stress, marked by an increase in reactive oxygen species (ROS) production.
Barcelos, Isabella Peixoto de +1 more
core +1 more source
Understanding the Intersections between Metabolism and Cancer Biology [PDF]
, 2017 Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth.
DeBerardinis, Ralph J. +1 more
core +1 more source
Scientific ReportsLeflunomide (LF) is an immunomodulator classified as a disease-modifying anti-rheumatic agent. Its mechanisms of action include inhibition of dihydroorotate dehydrogenase in lymphocytes, resulting in immunosuppressive effects, and blocking tyrosine ...
Carlos Alonso Leite dos Santos +8 more
doaj +1 more source
A validated bioluminescence-based assay for the rapid determination of the initial rate of kill for discovery antimalarials [PDF]
, 2016 Objectives: A future treatment for uncomplicated malaria will contain at least one component that exerts a rapid rate of kill (RoK). We describe here the validation and application of a simple, robust and rapid bioluminescence-based assay for the ...
Biagini, Giancarlo +3 more
core +4 more sources
Dihydroorotate dehydrogenases [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2000 S. Nørager +3 more
openaire +1 more source
OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens. [PDF]
, 2016 BACKGROUND The search for highly effective anti-malarial therapies has gathered pace and recent years have seen a number of promising single and combined therapies reach the late stages of development.
Aljayyoussi, Ghaith +3 more
core +3 more sources