New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. [PDF]
, 2012 CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups.
Cuff, Alison L +12 more
core +1 more source
Hamster-to-rat heart and liver xenotransplantation with FK506 plus antiproliferative drugs [PDF]
, 1993 Heterotopic hamster hearts transplanted to unmodified LEW rats underwent humoral rejection in 3 days. Survival was prolonged to a median of 4 days with 2 mg/kg/day FK506.
Cramer, D +6 more
core +1 more source
A HYPOKALEMIA CASE RES?STANT TO TREATMENT ASSOCIATED WITH LEFLUNOMIDE
Mediterranean Journal of Hematology and Infectious Diseases, 2014 Leflunomide is a disease-modifying antirheumatic drug which is used in the treatment of rheumatoid arthritis. It prevents inflammation by inhibition of dihydroorotate dehydrogenase, the enzyme responsible for de novo pyrimidine synthesis.
GÜLALİ AKTAŞ +4 more
doaj
Effect of farnesyltransferase inhibitor R115777 on mitochondria of plasmodium falciparum [PDF]
The parasite Plasmodium falciparum causes severe malaria and is the most dangerous to humans. However, it exhibits resistance to their drugs. Farnesyltransferase has been identified in pathogenic protozoa of the genera Plasmodium and the target of ...
Ha, YR +4 more
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MoleculesThe burden of human schistosomiasis, a known but neglected tropical disease in Sub-Saharan Africa, has been worrisome in recent years. It is becoming increasingly difficult to tackle schistosomiasis with praziquantel, a drug known to be effective against
Babatunji Emmanuel Oyinloye +12 more
doaj +1 more source
Alternative NAD(P)H dehydrogenase and alternative oxidase: proposed physiological roles in animals [PDF]
, 2019 The electron transport systems in mitochondria of many organisms contain alternative respiratory enzymes distinct from those of the canonical respiratory system depicted in textbooks.
Gospodaryov, Dmytro V. +1 more
core +1 more source
Synthesis and Antiplasmodial Activity of 1,2,3-Triazole-Naphthoquinone Conjugates
Molecules, 2019 A series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and against ...
Sandra Oramas-Royo +7 more
doaj +1 more source
DNA unwinding heterogeneity by RecBCD results from static molecules able to equilibrate. [PDF]
, 2013 Single-molecule studies can overcome the complications of asynchrony and ensemble-averaging in bulk-phase measurements, provide mechanistic insights into molecular activities, and reveal interesting variations between individual molecules.
Baskin, Ronald J +2 more
core
Novel Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia. [PDF]
ACS Med Chem Lett, 2023 Sabnis RW.
europepmc +2 more sources
Redox BiologyFerroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation, which plays a critical role in the pathogenesis of various diseases, including ischemic tissue injury, infectious diseases, neurodegenerative ...
Jinghao Cao +11 more
doaj +1 more source