Results 91 to 100 of about 7,944 (148)
Conformation of 1,4-dihydropyridine - planar or boat-like?
, 1988 The geometry of the 1,4-dihydropyridine molecule was completely optimized employing three different ab initio basis sets (6–31 G*, 4–31 G, STO—3G).
R. Cimiraglia +3 more
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Synthesis of 1,4-Dihydropyridine Derivatives Under Aqueous Media [PDF]
, 2010 An environmental friendly synthesis of 1,4-dihydropyridine derivatives was developed by the one-pot reaction of aldehydes, ethyl acetoacetate and ammonia in water under refluxing ...
Adeleh Moshtaghi Zonouz +1 more
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Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Many pathophysiological pathways associated with cardiovascular diseases involve multiple drug targets. This article reviews recent advances in the development of pharmacological compounds capable of simultaneously modulating multiple mechanisms. Multitarget drugs offer a promising therapeutic approach for complex cardiovascular disorders, including ...
Gyuzel Y. Mitronova +3 more
wiley +1 more source
Onset time of Ca antagonistic action of CD-349 in comparison with other dihydropyridine compounds
, 2007 AN0016561X-20071226-77We examined the relationship between the tissue distribution and the time of onset of the calcium antagonistic action of CD-349 in comparison with nicardipine and nitrendipine.
WATAJIMA, Hiroshi +12 more
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Diversity-Oriented Synthesis of 1‑Substituted 4‑Aryl-6-oxo-1,6-dihydropyridine-3-carboxamides.
, 2016 A simple five-step diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxamides was developed. Treatment of dimethyl 2-((dimethylamino)methylidene)-3-oxopentanedioate with twenty primary amines gave 1-substituted methyl ...
Jurij Svete (1447174) +6 more
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Scaffold Hopping Provides Liver X Receptor Agonist With Preference for the β Subtype
ChemMedChem, Volume 21, Issue 19, 14 October 2026.A scaffold hopping strategy was pursued to enhance the binding pocket engagement and β‐subtype selectivity of liver X receptor agonist 2. The resulting spirocyclic lead compound, (S)‐7, demonstrates superior potency, enhanced potency‐based selectivity for LXRβ, and improved microsomal stability over the existing scaffold.
Annette Kärcher +5 more
wiley +1 more source
Vascular drivers of cerebrospinal fluid movement and enlarged perivascular spaces
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract Perivascular spaces (PVSs) facilitate cerebrospinal fluid flow and waste clearance, which are critical for maintaining brain homeostasis. Enlarged PVSs (ePVSs) are an emerging marker of cerebral small vessel disease and are implicated in protein accumulation, neurodegeneration, and cognitive decline.
James D. LeFevre +2 more
wiley +1 more source
Рациональная фармакотерапия в кардиологии, 2015 The classification of calcium antagonists is presented. There were considered the results of large randomized trials, which were devoted to study of influence of dihydropyridine calcium antagonists on the risk of cardiovascular complications.
S. Y. Martsevich
doaj +1 more source
Cancer and Hypertension: Shared Mechanisms, Treatment Interactions, and Clinical Management
Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Cancer and hypertension (HTN) frequently coexist, and their relationship is increasingly recognized as a clinically relevant intersection between oncology and cardiovascular medicine. However, the extent to which this association reflects shared risk factors, common biological mechanisms, or treatment‐related effects remains incompletely ...
Peizhi Jia +5 more
wiley +1 more source
Synthesis and enantioseparation of 1,4-dihydropyridine ring containing condensed heterocycles
, 2012 Sintezētas 1,4-dihidropiridīn-6-merkaptoetiķskābes un 6-metilsulfanil-1,4-dihidropiridīn-3-karbonskābes, pētīta to diastereomēru kristalizācija ar cinhonīnu.
Adlere, Ilze
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