Results 101 to 110 of about 7,944 (148)

High-affinity antibodies to the 1,4-dihydropyridine Ca2+- channel blockers (nitrendipine/nifedipine/nisoldipIne/Ca2' antgonsts/dihydropyridlne receptor)

, 2020
Antibodies with affinity and specificity for the 1,4-dihydropyridine Ca2+-channel blockers have been produced in rabbits by immunization with dihydropyridine-protein conjugates. Drugs that block these voltage-dependent Ca2' channels are used for the
Alan Sharp, Kevin P Campbell, Steven D Kahl, AND Molly Strom   +3 more
core  

Synthesis and structural conformation studies of a potent unsymmetrical 1,4-dihydropyridine

, 2008
2,6-Dimethyl-5-(phenylcarbamoyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-2-carboxylate was synthesized in two steps and was characterized spectroscopically and confirmed by X-ray diffraction studies.
Naveen, S., Arun Mishra, Shashidhara Prasad, J., Dinesh Manvar, Anandalwar, S. M., Anamik Shah   +5 more
core   +1 more source

Green MW/US‐Assisted Construction of Pyrano[2,3‐b]pyridines and Pyrazolo[3,4‐d]pyrimidinones: Pathway Control and Antibacterial Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
A rapid, green MW/US‐assisted route was developed for synthesizing coumarin/azacoumarin‐based fused heterocycles. It enables efficient construction of pyrano[2,3‐b]pyridines and pyrazolo[3,4‐d]pyrimidinones under mild conditions. FT‐IR, NMR, MS, and elemental analysis fully confirmed the structures of the new products.
Sultanah M. Alhunayhin, Ayman M. Algohary, Youssef O. Al‐Ghamdi, Mohamed Abdel‐Megid, Asmaa M. Fahim, Sameh A. Rizk   +5 more
wiley   +1 more source

Synthesis and (spectro)electrochemical investigations of coordinatively-saturated (cyclopentadienyl)ruthenium-Hantzsch pyridinium/dihydropyridine conjugates

, 2016
Complexes with the CpRu(PPh3) fragment bound by iminopyridine ligands functionalised by a Hantzsch dihydropyridine donor of hydride ion or by a Hantzsch pyridinium acceptor of hydride ion have been prepared, and their redox chemistry studied by cyclic ...
McSkimming, A, Colbran, SB, Bhadbhade, MM ; https://orcid.org/   +2 more
core   +1 more source

Stereoselective reduction of benzoin by the NADH model 3-(dimethylcarbamoyl)-1,2,4-trimethyl-1,4-dihydropyridine [PDF]

, 1990
The Mg(ClO4)2-induced reduction of racemic benzoin by the racemic NADH model compound 3-(dimethylcarbamoyl)-1,2,4-trimethyl-1,4-dihydropyridine (1), in accordance to Cram's rule, leads exclusively to meso-1,2-diphenyl-1,2-ethanediol.
Vekemans, J.A.J.M., Beijer, N.A., Buck, H.M.   +2 more
core   +1 more source

Diethyl 4-(2,4-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Acta Crystallographica Section E, 2010
In the title compound, C19H21Cl2NO4, the dihydropyridine ring adopts a flattened boat conformation. The dichlorophenyl ring is oriented almost perpendicular to the planar part of the dihydropyridine ring [dihedral angle = 89.1 (1)&#176 ...
P. Palakshi Reddy, V. Vijayakumar, J. Suresh, T. Narasimhamurthy, P. L. Nilantha Lakshman   +4 more
doaj   +1 more source

Small Molecule Therapeutic Approaches With a Greater Focus on Hearing Loss: A Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Hearing loss (HL) is one of the most common sensory impairments worldwide and has substantial effects on quality of life and daily functioning. Although cochlear implants and hearing aids have markedly improved the management of hearing impairment, these devices do not directly address the underlying pathogenic mechanisms ...
Maryam Naghinejad, Farzaneh Motallebi, Elaheh Hasani, Moein Kohkalani, Sepideh Parvizpour, Sima Mansoori Derakhshan   +5 more
wiley   +1 more source

1,4-Dihydropyridine activators in the tiamdipine series.

, 1990
The pharmacologic and radioligand binding properties of 5-nitro analogs of the 1,4-dihydropyridine Ca2+ channel antagonist, tiamdipine (2-(2-aminoethylthio)methyl-3-carbomethoxy-5-carbomethoxy-6-m ethyl-4-(3-nitrophenyl)-1,4-dihydropyridine) and its N ...
Triggle DJ, Luchowski E, GALLETTI, FERRUCCIO   +2 more
core  

Diethyl 4-(1H-indol-3-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

IUCrData, 2019
In the title compound, C21H24N2O4, the 1,4-dihydropyridine ring adopts a very flattened boat conformation, with the 3-pyridine substituent in an axial orientation.
Ji Hye Lee, Dongsoo Koh
doaj   +1 more source

Genetic and Pharmacologic Inhibition of Myostatin Restores Muscle Mass in a Dynamin 2‐Related Centronuclear Myopathy Mouse Model

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Autosomal dominant centronuclear myopathy (ADCNM), most commonly caused by mutations in the dynamin 2 (DNM2) gene, is a rare congenital myopathy characterized by progressive muscle weakness and atrophy. Myostatin, a key negative regulator of skeletal muscle mass, has shown therapeutic potential in several models of neuromuscular ...
Durieux Anne‐Cécile, Arnould David, Velarde Mathias, Allibert Valentine, Paret Chloé, Debelley Quentin, Kizilkilic Esra, Chambon Sidney, Girard Emmanuelle, Collin Louise, Gensel Alexandre, Castells Josiane, Pasternack Aja, Bowen Maximilien, Morel Baptiste, Hourdé Christophe, Laurent Schaeffer, Ritvos Olli, Bitoun Marc, Mounier Rémi, Freyssenet Damien   +20 more
wiley   +1 more source