Results 41 to 50 of about 26,691 (223)

Dual‐Functional Polystyrene‐Based Borate Complexes: Recyclable Alkyl Radical Sources and Photodegradable Absorbents

Chemistry – A European Journal, EarlyView.
Dual‐functional polystyrene‐based polymers bearing 2,2′‐(pyridine‐2,6‐diyl)diphenol (PDP) moieties form photoexcitable alkyl borate complexes: (i) As recyclable radical sources, they enable Giese‐type additions with facile purification by reprecipitation and demonstrate proof‐of‐concept for polymer recovery (50% PDP regeneration).
Nami Jimba, Ryosei Ishii, Kazuki Wako, Tomoki Hirohata, Kosuke Sato, Tomohiro Kubo, Kotaro Satoh, Yuto Sumida, Hirohisa Ohmiya, Shinsuke Inagi   +9 more
wiley   +1 more source

Tetrodotoxin as a Tool to Elucidate Sensory Transduction Mechanisms: The Case for the Arterial Chemoreceptors of the Carotid Body

Marine Drugs, 2011
Carotid bodies (CBs) are secondary sensory receptors in which the sensing elements, chemoreceptor cells, are activated by decreases in arterial PO2 (hypoxic hypoxia).
Constancio Gonzalez, Ana Obeso, Ana Isabel Caceres, Asuncion Rocher   +3 more
doaj   +1 more source

Synthesis, Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET) and molecular docking studies of some pyridin-2(1H)-one derived from a Apocynin in Thi-Qar Governorate

مجلة علوم ذي قار, 2023
The present study includes synthesized of some pyridin-2(1H)- one of 1-(4-hydroxy-3-methoxyphenyl) ethan-1-one. The [ 6-(4-hydroxy-3-methoxyphenyl) - 4 - (4-methoxyphenyl) - 2 - oxo-1,2-dihydropyridine - 3- carbonitrile, 4 - (4-bromophenyl) - 6 -(4 ...
Entedhar Thejeel, Athraa Hameed Mekky
doaj   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source

Facile and rapid synthesis of piperidinium-6-amino-4-aryl-3, 5-dicyano-1,4-dihydropyridine-2-thiolate

, 2019
A fast and convenient protocol for the synthesis of a new class of piperidin-1-ium 6-amino-4-aryl-3,5-dicyano-1,4-dihydropyridine-2-thiolate (piperidinium salt) derivatives is developed by the one-pot, three-component reactions of cyanothioacetamide ...
Milad Masoumi (5771438), Mohammad Bayat (3335955), Fahimeh Sadat Hosseini (4753608)   +2 more
core   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Study on optimization of synthesis process of dihydropyridine by one-pot method

Siliao yanjiu, 2023
The experiment was to optimize the synthesis of dihydropyridine by one-pot method. Dihydropyridine was synthesized from urotropine, ethyl acetoacetate and ammonium acetate aqueous solution with ethanol as the solvent by a one-pot method.
MIN Jiang, LIANG Jing-le, LIU Zheng-guang, ZHAO Cai-bing, LOU Yan, ZHAO Teng-fei   +5 more
doaj  

Diethyl 4-(4-chloro-2-propyl-1H-imidazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate monohydrate

IUCrData, 2018
In the title hydrate, C19H26ClN3O4·H2O, the imidazole ring is nearly perpendicular [dihedral angle = 89.5 (1)°] to the dihydropyridine moiety. The propyl and one of the ethyl groups are disordered over two resolved sets of sites [occupancy factors 0.524 (
Kedila Rasheeda, Seranthimata Samshuddin, Phadke N. Swathi, Vijaya D. P. Alva, Joel T. Mague, Youssef Ramli   +5 more
doaj   +1 more source

Synthesis and Characterisation of 1,1′-{[3,5-Bis(dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) Dibromide

Molbank, 2021
In the present work, construction of double-charged cationic amphiphilic 1,1′-{[3,5-bis(dodecyl¬oxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide (7) was performed in four steps.
Martins Rucins, Karlis Pajuste, Aiva Plotniece, Nadiia Pikun, Roman Rodik, Sergiy Vyshnevskiy, Arkadij Sobolev   +6 more
doaj   +1 more source

Therapeutic‐dose verapamil‐induced cardiogenic shock in an older patient: a case report

Journal of Pharmacy Practice and Research, EarlyView.
Abstract Background Calcium channel blocker (CCB) toxicity most commonly follows deliberate overdose. However, severe toxicity at therapeutic doses may occur in susceptible individuals. Severe CCB toxicity often presents with clinical features of bradycardia, hypotension, hyperglycaemia, and lactic acidosis.
Christopher Thuring, Maria Carey, Timothy Webber, Biswadev Mitra   +3 more
wiley   +1 more source