Results 41 to 50 of about 7,944 (148)

Synthesis, Absorption, Distribution, Metabolism, Excretion, Toxicology (ADMET) and molecular docking studies of some pyridin-2(1H)-one derived from a Apocynin in Thi-Qar Governorate

مجلة علوم ذي قار, 2023
The present study includes synthesized of some pyridin-2(1H)- one of 1-(4-hydroxy-3-methoxyphenyl) ethan-1-one. The [ 6-(4-hydroxy-3-methoxyphenyl) - 4 - (4-methoxyphenyl) - 2 - oxo-1,2-dihydropyridine - 3- carbonitrile, 4 - (4-bromophenyl) - 6 -(4 ...
Entedhar Thejeel, Athraa Hameed Mekky
doaj   +1 more source

Dihydropyridine Isomerism in the Chemical Delivery System Series [PDF]

, 1993
A theoretical study was performed for three structured isomers of the dihydropyridine-targetor btised chemical delivery systems of estradiol euid azidothymine.
Bodor, Nicholas, Brewster, Marcus E., Huang, Ming-Ju, Pop, Emil   +3 more
core   +1 more source

Study on optimization of synthesis process of dihydropyridine by one-pot method

Siliao yanjiu, 2023
The experiment was to optimize the synthesis of dihydropyridine by one-pot method. Dihydropyridine was synthesized from urotropine, ethyl acetoacetate and ammonium acetate aqueous solution with ethanol as the solvent by a one-pot method.
MIN Jiang, LIANG Jing-le, LIU Zheng-guang, ZHAO Cai-bing, LOU Yan, ZHAO Teng-fei   +5 more
doaj  

Diels–Alder Reactions of α‑Amido Acrylates with N‑Cbz-1,2-dihydropyridine and Cyclopentadiene

, 2016
Thermal Diels–Alder reactions of α-amido acrylates with N-Cbz-1,2-dihydropyridine and cyclopentadiene have been explored to investigate the factors influencing the endo/exo selectivity.
Hossay Abas (3188169), Christopher S. Frampton (1329555), Alan C. Spivey (1883209)   +2 more
core   +2 more sources

Diethyl 4-(4-chloro-2-propyl-1H-imidazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate monohydrate

IUCrData, 2018
In the title hydrate, C19H26ClN3O4·H2O, the imidazole ring is nearly perpendicular [dihedral angle = 89.5 (1)°] to the dihydropyridine moiety. The propyl and one of the ethyl groups are disordered over two resolved sets of sites [occupancy factors 0.524 (
Kedila Rasheeda, Seranthimata Samshuddin, Phadke N. Swathi, Vijaya D. P. Alva, Joel T. Mague, Youssef Ramli   +5 more
doaj   +1 more source

Synthesis and Characterisation of 1,1′-{[3,5-Bis(dodecyloxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) Dibromide

Molbank, 2021
In the present work, construction of double-charged cationic amphiphilic 1,1′-{[3,5-bis(dodecyl¬oxy-carbonyl)-4-(thiophen-3-yl)-1,4-dihydropyridine-2,6-diyl]bis-(methylene)}bis(pyridin-1-ium) dibromide (7) was performed in four steps.
Martins Rucins, Karlis Pajuste, Aiva Plotniece, Nadiia Pikun, Roman Rodik, Sergiy Vyshnevskiy, Arkadij Sobolev   +6 more
doaj   +1 more source

Dual‐Functional Polystyrene‐Based Borate Complexes: Recyclable Alkyl Radical Sources and Photodegradable Absorbents

Chemistry – A European Journal, EarlyView.
Dual‐functional polystyrene‐based polymers bearing 2,2′‐(pyridine‐2,6‐diyl)diphenol (PDP) moieties form photoexcitable alkyl borate complexes: (i) As recyclable radical sources, they enable Giese‐type additions with facile purification by reprecipitation and demonstrate proof‐of‐concept for polymer recovery (50% PDP regeneration).
Nami Jimba, Ryosei Ishii, Kazuki Wako, Tomoki Hirohata, Kosuke Sato, Tomohiro Kubo, Kotaro Satoh, Yuto Sumida, Hirohisa Ohmiya, Shinsuke Inagi   +9 more
wiley   +1 more source

Synthesis and crystal structures of four new dihydropyridine derivatives

, 2013
Four new Hantzsch 1,4-dihydropyridine derivatives, dimethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3, 5-dicarboxylate, (I), dimethyl 4-(4-bromophenyl)-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarboxylate, (II), dimethyl 4-(3-bromo ...
Butcher, Ray J., Pek, A. E., Narayana, B., Jasinski, J. P., Samshuddin, S., Guild, Curtis J., Yathirajan, H. S.   +6 more
core   +1 more source

RELATIONSHIP BETWEEN THE IN SILICO AND IN VIVO ANTIDIABETIC AND ANTIATHEROSCLEROTIC PROPERTIES OF NOVEL DIHYDROPYRIDINE AND THIENOPYRIDINE DERIVATIVES

Паёми Сино
Objective: To evaluate the relationship between the in silico and in vivo antidiabetic and antiatherosclerotic properties of novel dihydropyridine and thienopyridine derivatives using an experimental model of combined dietary loading followed by ...
Bibik Elena Yurievna, Ketova Elena Sergeevna, Krivokolysko Sergey Gennadievich   +2 more
doaj   +1 more source

Considerations for drug trials in hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1095-1112, April 2025.
Abstract Hypertrophic cardiomyopathy (HCM) is a heterogeneous condition with potentially serious manifestations. Management has traditionally comprised therapies to palliate symptoms and implantable cardioverter‐defibrillators to prevent sudden cardiac death. The need for disease‐modifying therapies has been recognized for decades.
John P. Farrant, Matthias Schmitt, Anna B. Reid, Clifford J. Garratt, William G. Newman, Aneil Malhotra, Rhys Beynon, Masliza Mahmod, Betty Raman, Robert M. Cooper, Dana Dawson, Thomas Green, Sanjay K. Prasad, Anvesha Singh, Susanna Dodd, Hugh Watkins, Stefan Neubauer, Christopher A. Miller   +17 more
wiley   +1 more source