Results 21 to 30 of about 148,764 (203)

Fluoropyrimidine-Induced Severe Toxicities Associated with Rare DPYD Polymorphisms: Case Series from Saudi Arabia and a Review of the Literature

Clinics and Practice, 2021
Dihydropyrimidine dehydrogenase (DPD) is the major enzyme in the catabolism of 5-Fluorouracil (5-FU) and its prodrug capecitabine. We report cases from our institute with colorectal cancer who experienced severe toxicities to standard dose 5-FU based ...
Nedal Bukhari, Abdulraheem Alshangiti, Emad Tashkandi, Mohammed Algarni, Humaid O. Al-Shamsi, Hamoud Al-Khallaf   +5 more
doaj   +1 more source

New Insights into rice pyrimidine catabolic enzymes

Frontiers in Plant Science, 2023
IntroductionRice is a primary global food source, and its production is affected by abiotic stress, caused by climate change and other factors. Recently, the pyrimidine reductive catabolic pathway, catalyzed by dihydropyrimidine dehydrogenase (DHPD ...
Andrea J. Lopez, Heidy Y. Narvaez-Ortiz, Maria A. Rincon-Benavides, Dania Camila Pulido, Luis Eduardo Fuentes Suarez, Barbara H. Zimmermann   +5 more
doaj   +1 more source

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

, 2022
Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil ...
Søren Feddersen (810295), Per Pfeiffer (427106), Fie Juhl Vojdeman (9559834), Claus Gyrup Nielsen (13978205), Ihab Bishara Yousef Lolas (13978217), Birgitte Bertelsen (4613584), Per Damkier (3443144), Anne Ramlov (13978202), Eva Greibe (171188), Troels K. Bergmann (13978235), Peter Plomgaard (322821), Peter Henrik Nissen (13978232), Palle B. Nielsen Fruekilde (13978223), Pernille Bøttger (13978226), Peter Clausager Petersen (13978229), Marianne Lerbaek Bergmann (13978220), Niels Herluf Paulsen (13978199), Heidi Hvid Nielsen (13978214), Stig Ejdrup Andersen (12037031), Camilla Qvortrup (645212), Elke Hoffmann-Lücke (13978208), Maria Rossing (3920183), Hanne Spangsberg Holm (13978211), Jonna Skov Madsen (5238674), Morten Mørk (2792266)   +24 more
core   +3 more sources

Impact of Guidelines Regarding Dihydropyrimidine Dehydrogenase (DPD) Deficiency Screening Using Uracil-Based Phenotyping on the Reduction of Severe Side Effect of 5-Fluorouracil-Based Chemotherapy: A Propension Score Analysis

Pharmaceutics, 2022
Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with severe fluoropyrimidines-induced toxicity. As of September 2018, French recommendations call for screening for DPD deficiency by plasma uracil quantification prior to all ...
Nicolas Laures, Céline Konecki, Mathias Brugel, Anne-Lise Giffard, Naceur Abdelli, Damien Botsen, Claire Carlier, Claire Gozalo, Catherine Feliu, Florian Slimano, Zoubir Djerada, Olivier Bouché   +11 more
doaj   +1 more source

Polymorphism of dihydropyrimidine dehydrogenase (DPYD) Cys29Arg and risk of six malignancies in Japanese [PDF]

, 2005
2005-06Dihydropyrimidine dehydrogenase (DPD) is the enzyme catalyzing the first step of pyrimidine metabolism. To date, genetic polymorphisms of pyrimidine-synthesizing enzymes have been reported to be associated with the risk of malignant lymphoma or ...
Hamajima, Nobuyuki, Kagami, Yoshitoyo, Yamamura, Yoshitaka, Shinoda, Masayuki, Iwata, Hiroji, Suyama, Motokazu, Hishida, Asahi, Hatooka, Shunzo, Mitsudomi, Tetsuya, Yamamoto, Kazuhito, Tamakoshi, Akiko, Ogura, Michinori, Tajima, Kazuo, Kato, Tomoyuki, Naito, Mariko, Tanaka, Daisuke, Matsuo, Keitaro   +16 more
core   +1 more source

Three different polymorphisms of the DPYD gene associated with severe toxicity following administration of 5-FU: a case report

Journal of Medical Case Reports, 2019
Background Dihydropyrimidine dehydrogenase deficiency secondary to polymorphisms in the DPYD gene can lead to significant toxicity associated with the administration of fluoropyrimidine chemotherapy.
Deborah Mukherji, Sarah Abdel Massih, Arafat Tfayli, Mariam Kanso, Walid Faraj   +4 more
doaj   +1 more source

Efficacy of laser capture microdissection plus RT-PCR technique in analyzing gene expression levels in human gastric cancer and colon cancer

BMC Cancer, 2008
Background Thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate phosphoribosyltransferase gene expressions are reported to be valid predictive markers for 5-fluorouracil sensitivity to gastrointestinal cancer.
Danenberg Peter V, Danenberg Kathleen, Uetake Hiroyuki, Makino Hiroshi, Sugihara Kenichi   +4 more
doaj   +1 more source

Impact of pharmacogenomic DPYD variant guided dosing on toxicity in patients receiving fluoropyrimidines for gastrointestinal cancers in a high-volume tertiary centre

BMC Cancer, 2023
Background Dihydropyrimidine dehydrogenase (DPD) is a key enzyme in the metabolism of fluoropyrimidines. Variations in the encoding DPYD gene are associated with severe fluoropyrimidine toxicity and up-front dose reductions are recommended.
David K. Lau, Caroline Fong, Faten Arouri, Lillian Cortez, Hannah Katifi, Reyes Gonzalez-Exposito, Muhammad Bilal Razzaq, Su Li, Aislinn Macklin-Doherty, Monica Arenas Hernandez, Michael Hubank, Charlotte Fribbens, David Watkins, Sheela Rao, Ian Chau, David Cunningham, Naureen Starling   +16 more
doaj   +1 more source

Potential Impact of DPYD Variation on Fluoropyrimidine Drug Response in sub-Saharan African Populations

Frontiers in Genetics, 2021
Cancer is a critical health burden in Africa, and mortality rates are rising rapidly. Treatments are expensive and often cause adverse drug reactions (ADRs).
Jorge E. B. da Rocha, Jorge E. B. da Rocha, Zané Lombard, Michèle Ramsay, Michèle Ramsay   +4 more
doaj   +1 more source

A Unique Case of a Patient with Rectal Cancer Who Developed Benign Esophageal Stenosis after Localized Rectal Radiation and Systemic Chemotherapy

Case Reports in Gastroenterology, 2015
Acute esophagitis and esophageal strictures typically occur after local radiation therapy to the thoracic field. Toxicity is usually limited to the field of radiation and potentially augmented by concomitant use of chemotherapy, however esophageal ...
Elie Chahla, Antonio Cheesman, Muhammad Hammami, Jason R. Taylor, Nishant Poddar, Robert W. Garrett, Samer Alkaade   +6 more
doaj   +1 more source