Results 31 to 40 of about 148,764 (203)

Correlations between expressions of DPD, LC3 and P62 in colorectal cancer and their clinical significance [PDF]

Zhongguo aizheng zazhi, 2022
Background and purpose: Colorectal cancer is one of the most common malignancies. The efficacy of 5-fluorouracil (5-FU) in the treatment of colorectal cancer is often affected by drug resistance or toxic side effects. Dihydropyrimidine dehydrogenase (DPD)
JIA Zhenzhen, HE Shuang, LI Yangyang, WEN Feifei, XU Xiaoyang, GUO Ningjie, WU Shuhua
doaj   +1 more source

Uridine triacetate for severe 5-fluorouracil toxicity in a patient with thymidylate synthase gene variation: Potential pharmacogenomic implications

SAGE Open Medical Case Reports, 2018
Adverse drug reactions can be unpredictable. However, pharmacogenomic testing can help identify patients who may be more susceptible to the toxic effects of certain drugs. Genetic variations in the dihydropyrimidine dehydrogenase and thymidylate synthase
Candice Baldeo, Prakash Vishnu, Kabir Mody, Pashtoon Murtaza Kasi   +3 more
doaj   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update [PDF]

, 2017
The purpose of this guideline is to provide information for the interpretation of clinical dihydropyrimidine dehydrogenase (DPYD) genotype tests so that the results can be used to guide dosing of fluoropyrimidines (5-fluorouracil and capecitabine ...
Schellens, Jan H M, Swen, Jesse J, Klein, T.E., Julia Barbarino, Kelly E. Caudle, Diasio, R.B., Caudle, K.E., Steven M. Offer, Amstutz, U., Schwab, M., Afd Pharmacoepi & Clinical Pharmacology, Barbarino, J., Schellens, J.H.M., Schwab, Matthias, Pharmacoepidemiology and Clinical Pharmacology, Linda M. Henricks, McLeod, H.L., Offer, S.M., Amstutz, Ursula, Swen, Jesse J., Jesse J. Swen, Henricks, L.M., Jan H.M. Schellens, Caudle, Kelly E, Klein, Teri E, Matthias Schwab, Barbarino, Julia, Henricks, Linda M, Robert B. Diasio, Swen, J.J., McLeod, Howard L, Howard L. McLeod, Offer, Steven M, Ursula Amstutz, Teri E. Klein, Diasio, Robert B   +35 more
core   +3 more sources

Investigation of Ivs14+1G>A Polymorphism of Dpyd Gene in a Group of Bosnian Patients Treated with 5-Fluorouracil and Capecitabine

Biomolecules & Biomedicine, 2010
Adverse drug reactions still pose an important clinical problem. Dihydropyrimidine dehydrogenase (DPD) is an enzyme that regulates 5-FU quantities available for anabolic processes and hence affects its pharmacokinetics, toxicity and efficacy. There are
Timur Cerić, Nermina Obralić, Lejla Kapur-Pojskić, Draženka Macić, Semir Bešlija, Anes Pašić, Šejla Cerić   +6 more
doaj   +1 more source

Experimental study on influence of autophagy on DPD expression and its effect on chemotherapy with 5-FU in colorectal cancer [PDF]

Zhongguo aizheng zazhi, 2022
Background and purpose: Colorectal cancer is one of the most common digestive system malignancies, and chemotherapy for colorectal cancer and drug resistance have always been concerns.
Zhongze CUI, Shuang HE, Feifei WEN, Yangyang LI, Xiaoyang XU, Lizhen LU, Shuhua WU   +6 more
doaj   +2 more sources

Dihydropyrimidine dehydrogenase deficiency caused by a novel genomic deletion c.505_513del of DPYD.

, 2021
Dihydropyrimidine dehydrogenase (DPD) deficiency is an autosomal recessive disorder of the pyrimidine degradation pathway. In a patient presenting with convulsions, psychomotor retardation and Reye like syndrome, strongly elevated levels of uracil and ...
Miny, P., Mori, A. Capone, Meijer, J., Gokcay, Gülden Fatma, Bierau, J., van Kuilenburg, A. B. P., Fowler, B., de Die-Smulders, C. E. M., Macke, K., Mul, A. N. P. M., Rubio-Gozalbo, M. E., Sass, J. O., Zoetekouw, L., Nicolai, J., Hennermann, J. B., Meinsma, R., Vijzelaar, R., Hennekam, R. C. M., Roelofsen, J., Baykal, T., Weber, P.   +20 more
core   +2 more sources

Current Development of Anti-Cancer Drug S-1 [PDF]

Journal of Clinical and Diagnostic Research, 2016
S-1 is a novel oral fluoropyrimidine derivative, widely used for treating gastric, pancreatic, lung, head, neck and breast carcinomas. It is designed to enhance the clinical utility of an oral fluoropyrimidine and is associated with low gastrointestinal
Pratima Chhetri, Anil Giri, Suraj Shakya, Sujana Shakya, Binaya Sapkota, KC Pramod   +5 more
doaj   +1 more source

Administration of adjuvant oral tegafur/uracil chemotherapy post hepatocellular carcinoma resection: A randomized controlled trial

Asian Journal of Surgery, 2016
Background: Recurrence of hepatocellular carcinoma (HCC) after surgery is frequent, and is an important factor adversely influencing the long-term survival of patients.
Mitsuru Ishizuka, Keiichi Kubota, Takehiko Nemoto, Mitsugi Shimoda, Masato Kato, Yukihiro Iso, Kazuma Tago   +6 more
doaj   +1 more source

Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects [PDF]

British Journal of Clinical Pharmacology, 1998
Aims  Dihydropyrimidine dehydrogenase (DPD) catalyses the reduction of pyrimidines, including the anticancer agent 5‐fluorouracil (5FU). Impaired 5FU degradation, through low DPD activity, has led to severe, life‐threatening or fatal toxicity after administration of 5FU.
Ridge SA, Sludden J, Brown O, Robertson L, Wei X, Sapone A, Fernadez-Salguero PM, Gonzalez FJ, Vreken P, van Kuilenburg ABP, van Gennip AH, McLeod HL   +11 more
openaire   +3 more sources

G (rs2297595) on dihydropyrimidine dehydrogenase activity: Implication for 5‐fluorouracil toxicity [PDF]

, 2021
AIMS The aim of this study was to identify risk variants and haplotypes that impair dihydropyrimidine dehydrogenase (DPD) activity and are, therefore, candidate risk variants for severe toxicity to 5-fluorouracil (5-FU) chemotherapy.
Meulendijks, Didier, Stefan Schürch, Nakas, Christos, Stefano Fontana, Dominic Schärer, Hamzic, Seid, Seid Hamzic, Largiadèr, Carlo R., Steven M. Offer, Schürch, Stefan, Robert B. Diasio, Didier Meulendijks, Offer, Steven M., Marc Wehrli, Christos Nakas, Carlo R. Largiadèr, Amstutz, Ursula, Wehrli, Marc, Ursula Amstutz, Schärer, Dominic, Diasio, Robert B, Fontana, Stefano   +21 more
core   +2 more sources