Results 51 to 60 of about 148,764 (203)

DPYD and UGT1A1 Genotype‐Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant‐Specific Impact on Treatment Intensity and Toxicity

International Journal of Cancer, EarlyView.
Pre‐treatment DPYD and UGT1A1 genotyping is increasingly used to prevent fluoropyrimidine‐ and irinotecan‐related toxicity, but variant‐specific real‐world effects remain unclear. In an unselected cohort of cancer patients with actionable genotypes, genotype‐driven dosing improved safety while preserving treatment exposure in high‐risk DPYD c.1905+1G>A
Martina Gambron, Elena Peruzzi, Samantha Perfler, Marcella Montico, Riccardo Cecchin, Elena De Mattia, Michele Spina, Camilla Lisanti, Serena Corsetti, Luisa Foltran, Fabio Puglisi, Rossana Roncato, Erika Cecchin   +12 more
wiley   +1 more source

Case report: 5-Fluorouracil treatment in patient with an important partial DPD deficiency

Frontiers in Oncology, 2023
Esophageal cancer is a cancer with poor prognosis and the standard 1st line treatment for metastatic or recurrent EC is systemic chemotherapy with doublet chemotherapy based on platinum and 5-fluorouracil (5-FU). However, 5-FU could be a source of severe
Antonin Schmitt, Antonin Schmitt, Bernard Royer, Romain Boidot, Joseph Berthier, François Ghiringhelli, François Ghiringhelli   +6 more
doaj   +1 more source

Advances in the Protective Effects and Mechanisms of β‐Aminoisobutyric Acid in Maintaining Multi‐Organ Homeostasis

Medicine Bulletin, EarlyView.
ABSTRACT β‐Aminoisobutyric acid (BAIBA) is an exercise‐responsive myokine/metabolite released by skeletal muscle and has attracted increasing interest as a potential exercise mimetic and therapeutic candidate in preclinical research. BAIBA acts locally in skeletal muscle and can also reach distal organs through the circulation, contributing to the ...
Hao‐Zhe Wang, Wen‐Bi He, Fei‐Peng Chen, Jiong‐Xing Huang, Lin Zhu, Xiao‐Guang Liu   +5 more
wiley   +1 more source

Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil concentrations

, 2022
Dihydropyrimidine dehydrogenase (DPD) genotype and phenotype among Danish cancer patients: prevalence and correlation between DPYD-genotype variants and P-uracil ...
Andersen, Stig Ejdrup, Nissen, Peter Henrik, Damkier, Per, Aalborg University Hospital, Department of Clinical Biochemistry, Hoffmann-Lücke, Elke, Bergmann, Marianne Lerbaek, Feddersen, Søren, Qvortrup, Camilla, Vojdeman, Fie Juhl, University of Southern Denmark, Mørk, Morten, Plomgaard, Peter, Bergmann, Troels K., Bertelsen, Birgitte, Spangsberg Holm, Hanne, Klinik Diagnostik, Paulsen, Niels Herluf, Rossing, Maria, Petersen, Peter Clausager, Lolas, Ihab Bishara Yousef, Ramlov, Anne, The Faculty of Medicine, Nielsen, Heidi Hvid, University of Copenhagen, Regional Hospital Southern Denmark, Pfeiffer, Per, Sjællands Universitetshospital, Bøttger, Pernille, Aarhus University, Department of Molecular Diagnostics, Fruekilde, Palle B. Nielsen, Madsen, Jonna Skov, Nielsen, Claus Gyrup, Aalborg University, Greibe, Eva   +35 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, Volume 20, Issue 8, Page 1913-1932, August 2026.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019

Current Oncology, 2021
The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2019 was held in Morell, Prince Edward Island, 19–21 September 2019. Experts in medical oncology, radiation oncology, and surgical oncology who are involved in the management of ...
Joanna Gotfrit, Rachel Goodwin, Timothy Asmis, Angela J. Hyde, Thierry Alcindor, Francine Aubin, Scott Berry, Dominick Bossé, Colin Brown, Ronald Burkes, Margot Burnell, Bruce Colwell, Jessica Corbett, Jeff Craswell, Nathalie Daaboul, Mark Doherty, D. A. Barry Fleming, Luisa Galvis, Rakesh Goel, Mohammed Harb, Alwin Jeyakumar, Derek Jonker, Erin Kennedy, Michael Lock, Aamer Mahmud, Patrick H. McCrea, Vimoj Nair, Rami Nassabein, Carolyn Nessim, Ravi Ramjeesingh, Muhammad Raza, Wissam Saliba, Satareh Samimi, Simron Singh, Stephanie Snow, Mustapha Tehfé, Michael Thirlwell, Mario Valdes, Stephen Welch, Michael Vickers   +39 more
doaj   +1 more source

Analysis of the dihydropyrimidine dehydrogenase polymorphism in a British population [PDF]

British Journal of Clinical Pharmacology, 1996
Subjects with low or absent dihydropyrimidine dehydrogenase activity (DPD) are at risk of excessive toxicity or death when undergoing fluoropyrimidine chemotherapy. The DPD polymorphism has not been well characterized in the general population and the frequency of the enzyme deficiency is not known.
J, McMurrough, H L, McLeod
openaire   +2 more sources

Advancing gambogic acid for translational oncology: Redox–proteostasis collapse, multidrug resistance reversal, nanodelivery and biomarker‐guided development

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Gambogic acid exerts anticancer effects through reactive oxygen species‐mediated apoptosis, suppression of nuclear factor kappa B and phosphatidylinositol‐3‐kinase–protein kinase B signalling, multidrug resistance modulation and tumour microenvironment effects.
Uttam Singh Baghel, Kajal Gurow, Geetanjali Mehara, Priyanka Kriplani, Neelam M. Patel, Abhay Sharma, Deeksha Singh, Atamjit Singh, Suchi Dave, Bhawani Singh, Lashyn N. Kiyekbayeva, William N. Setzer, Javad Sharifi‐Rad, Cheryl Grace Pratiwi Rumahorbo, Daniela Calina   +14 more
wiley   +1 more source

Thermal and photochemical reactions of dihydrodiazines [PDF]

, 1979
This thesis describes the results of an investigation into the thermal and photochemical reactivity of dihydrodiazines.In order to prepare the title compounds the diazines and some phenyldiazines are treated with phenyllithium in ether, yielding adducts ...
Stoel, R.E., van der, van der Stoel, R.E.   +1 more
core  

Characterization of the Human Dihydropyrimidine Dehydrogenase Gene

Genomics, 1998
Dihydropyrimidine dehydrogenase (DPD) catabolizes endogenous pyrimidines and pyrimidine-based antimetabolite drugs. A deficiency in human DPD is associated with congenital thymine-uraciluria in pediatric patients and severe 5-fluorouracil toxicity in cancer patients. The dihydropyrimidine dehydrogenase gene (DPYD) was isolated, and its physical map and
X, Wei, G, Elizondo, A, Sapone, H L, McLeod, H, Raunio, P, Fernandez-Salguero, F J, Gonzalez   +6 more
openaire   +2 more sources