Results 61 to 70 of about 148,764 (203)

The Dual Role of the Gut Microbiota in Cancer Chemoresistance

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Comparison between Microbiota and Cancer therapy. ABSTRACT Chemoresistance is one of the primary reasons that cancer chemotherapy fails to deliver successful treatment outcomes and contributes to poor overall survival rates for patients with cancer. New research has begun to shed light on the effects of the gut microbiome (GM).
Hamed Tahmasebi, Aisa Bahar, Meisam Khazaei, Mohammad Reza Arabestani   +3 more
wiley   +1 more source

A case of a life-threatening toxicity following capecitabine treatment: advocacy for dihydropyrimidine dehydrogenase deficiency screening

, 2020
We discuss a life-threatening case of capecitabine toxicity due to the presence of a heterozygous variant on exon 14 (c.1905+1G>A, rs3918290) of the dihydropyrimidine dehydrogenase gene (DPYD).
Houssiau, Hélène, Carlier, Séverine, Whenham, Nicolas, Poncin, Renaud, Haufroid, Vincent, Duck, Lionel   +5 more
core  

Chronotherapy in Hematological Malignancies: Evaluating the Rationale and Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Hematological malignancies remain one of the leading causes of morbidity and mortality despite advances in targeted therapies, immunotherapy, and stem cell transplantation. Emerging evidence indicates that treatment efficacy and toxicity depend not only on the choice of therapy but also on its timing relative to the patient's internal ...
Andrej Belančić, Marko Skelin, Yun Wah Lam, Almir Fajkić, Bruna Perkov‐Stipičin, Rossana Roncato, Ivan Krečak, Marko Lucijanić   +7 more
wiley   +1 more source

Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers

Journal for ImmunoTherapy of Cancer
Background Tumor-associated macrophages participate in the complex network of support that favors tumor growth. Among the various strategies that have been developed to target these cells, the blockade of the colony-stimulating factor 1 receptor (CSF-1R)
Arnaud Millet, Khaldoun Gharzeddine, Cristina Gonzalez Prieto, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Fabienne Thomas, Marie-Hélène Laverriere, Edouard Girard, Gael Roth   +11 more
doaj   +1 more source

Osteogenesis Imperfecta, Pseudoachalasia, and Gastric Cancer

Case Reports in Gastrointestinal Medicine, 2015
Osteogenesis imperfecta (OI) is a rare, inherited skeletal disorder characterized by abnormalities of type 1 collagen. Malignancy is rarely reported in patients with OI and it was suggested that this disease can protect against cancer.
Dilsa Mizrak, Ali Alkan, Batuhan Erdogdu, Gungor Utkan   +3 more
doaj   +1 more source

Omics Biomarkers in Precision Oncology: From the Lens of the ASCPT Biomarkers and Translational Tools and Oncology Communities

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Omics biomarkers comprise several molecular entities, including genomic, epigenomic, transcriptomic, proteomic, and metabolomic signatures. They play an essential role in oncology drug development and clinical settings by enabling personalized medicine.
Mai Mehanna, Hardik Mody, Joy C. Hsu, Julia Quintanilha, Zachary L. Taylor, Angela James, Binita Rajbanshi, Pooja Manchandani, Lakshmi Manasa Chekka   +8 more
wiley   +1 more source

Dihydropyrimidine Dehydrogenase Testing prior to Treatment with 5-Fluorouracil, Capecitabine, and Tegafur: A Consensus Paper. [PDF]

, 2020
BACKGROUND 5-Fluorouracil (FU) is one of the most commonly used cytostatic drugs in the systemic treatment of cancer. Treatment with FU may cause severe or life-threatening side effects and the treatment-related mortality rate is 0.2-1.0%. SUMMARY
Carsten Bokemeyer, Ralf-Dieter Hofheinz, Wörmann, Bernhard, Schlegelberger, Brigitte, Lorenz Trümper, Burmeister, Thomas, Brigitte Schlegelberger, Pox, Christian, Thomas Decker, Matthias Stroth, Hofheinz, Ralf-Dieter, Volker Kunzmann, Sylvie Lorenzen, Gunnar Folprecht, Ewald Wöll, Sara Brucker, Claus-Henning Köhne, Eisterer, Wolfgang, Martin Wilhelm, Knauf, Wolfgang, Markus Borner, Cascorbi, Ingolf, Borner, Markus, Thomas Burmeister, Hoffmann, Jürgen, Wöll, Ewald, Dirk Arnold, Lüftner, Diana, Moehler, Markus, Hilbe, Wolfgang, Christian Pox, Marianne Sinn, Lorenzen, Sylvie, Bokemeyer, Carsten, Thomas Seufferlein, Köhne, Claus-Henning, Jens-Uwe Blohmer, Wolfgang Eisterer, Wilhelm, Martin, Arnold, Dirk, Folprecht, Gunnar, Andreas Dietz, Anke Reinacher-Schick, Stroth, Matthias, Markus Moehler, Reinacher-Schick, Anke, Schwab, Matthias, Nöthen, Markus M, Decker, Thomas, de Wit, Maike, Trümper, Lorenz, Sinn, Marianne, Blohmer, Jens-Uwe, Seufferlein, Thomas, Jürgen Hoffmann, Markus M. Nöthen, Dietz, Andreas, Largiadèr, Carlo R., Tamm, Ingo, Matthias Schwab, Ingolf Cascorbi, Hermann Einsele, Diana Lüftner, Brucker, Sara, Kunzmann, Volker, Wolfgang Hilbe, Bernhard Wörmann, Scharl, Anton, Maike de Wit, Wolfgang Knauf, Ingo Tamm, Anton Scharl, Einsele, Hermann, Carlo R. Largiadèr, Nöthen, Markus M.   +74 more
core   +1 more source

Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression

BMC Cancer, 2009
Background Microsatellite instability (MSI) refers to mutations in short motifs of tandemly repeated nucleotides resulting from replication errors and deficient mismatch repair (MMR).
Kruhøffer Mogens, Vainer Ben, Jensen Søren A, Sørensen Jens B   +3 more
doaj   +1 more source

Evaluation of adverse effects of chemotherapy regimens of 5-fluoropyrimidines derivatives and their association with DPYD polymorphisms in colorectal cancer patients

BMC Cancer, 2020
Background 5-Fluorouracil (5-FU) and capecitabine are fluoropyrimidine derivatives that mainly metabolized with dihydropyrimidine dehydrogenase enzyme (DPD).
Reza Negarandeh, Ebrahim Salehifar, Fatemeh Saghafi, Hossein Jalali, Ghasem Janbabaei, Mohammad Javad Abdhaghighi, Anahita Nosrati   +6 more
doaj   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, Volume 13, Issue 36, 29 June 2026.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source