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Tetrahydroindolone‐Dihydropyrimidinone Hybrids as Promising Antibiofilm and Antibacterial Agents
ChemMedChemIn the pursuit of novel therapeutic agents with enhanced antimicrobial properties, a new series of hybrid compounds combining the tetrahydroindolones and dihydropyrimidinones scaffolds is designed and synthesized in good yields. The hybridization strategy aims to merge the distinct biological functionalities of each pharmacophore ...
Vinicius Vendrusculo +6 more
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ChemInform Abstract: Recent Progress in the Chemistry of Dihydropyrimidinones
ChemInform, 2014AbstractReview: 24 refs.
Hirenkumar D. Shah, Dhrubo Jyoti Sen
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Medicinal perspective of a promising scaffold – dihydropyrimidinones: A review
Journal of Heterocyclic ChemistryAbstractDihydropyrimidinones (DHMPs) are the most important pharmacophore in Medicinal Chemistry. The synthetic approach for deriving DHMPs involves the Biginelli reaction or a combination of it with other multi‐component reactions (MCRs). The scaffold has received considerable attention due to its diverse therapeutic activity.
Bhavesh H. Sarvaiya +3 more
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Asymmetric Synthesis of Medicinally Important Dihydropyrimidinones
The Biginelli reaction is considered one of the well-known examples of a multicomponent reaction that is useful in the synthesis of dihydropyrimidinones (DHPMs) using aryl aldehydes, urea, and esters and these are significant compounds in medicinal chemistry and chemical synthesis.Rajni Sharma +2 more
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Synthesis and ct-DNA binding study of a donor-π-acceptor dihydropyrimidinone fluorophore
Journal of Molecular Structure, 2023Sankhadeep Dutta, Mohabul A Mondal
exaly
Introduction of dihydropyrimidinones: a medicinal chemistry perspective
2023Netra Prasad Neupane +2 more
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