Results 151 to 160 of about 1,000 (202)
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Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones
Archiv der Pharmazie, 2021AbstractIn this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1,3‐diones. The reaction was catalyzed by lanthanum triflate and completed within 1–1.5 h, with 74–97% yield.
Ruturajsinh M. Vala +7 more
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SAR studies on dihydropyrimidinone antibiotics
Bioorganic & Medicinal Chemistry Letters, 2011There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing ...
Lianhong, Xu +14 more
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Recent Advance in the Pharmacology of Dihydropyrimidinone
Mini-Reviews in Medicinal Chemistry, 2012Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and ...
J-P, Wan, Y, Pan
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The Biginelli Dihydropyrimidinone Synthesis
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
C. Oliver Kappe, Alexander Stadler
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A Versatile Synthesis of DihydropyrimidinoneC‐Nucleosides
Nucleosides, Nucleotides and Nucleic Acids, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Ram Chandra, Mishra +3 more
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Stereoselective synthesis of new dihydropyrimidinone glycoconjugates #
Journal of Heterocyclic Chemistry, 2005AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
G. V. M. Sharma +3 more
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Dihydropyrimidinones containing boronic acids
Canadian Journal of Chemistry, 2005The addition of formylphenylboronic acid derivatives to urea and ethyl acetoacetate proceeds in the absence of an additional Lewis acid catalyst to give the corresponding dihydropyrimidinones (Biginelli products) in good yields. Novel boron-containing dihydropyrimidinones have been investigated for their ability to act as anticancer agents against the
Johanna M Blacquiere +6 more
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Dihydropyrimidinones—a new class of anti-Staphylococcal antibiotics
Bioorganic & Medicinal Chemistry Letters, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael, Brands +4 more
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A recent update on the synthesis of dihydropyrimidinones/thiones
AIP Conference Proceedings, 2021Since its development in 1891 Biginelli’s three component synthesis of dihydropyrimidinones/ thiones, it is always on highlight of synthetic organic chemist. A variety of catalysts such as Lewis acid, organocatalyst, Bronsted acid catalyst, ionic liquid catalyst, microwave irradiation methods, ultrasound irradiation methods, grinding and solvent-free ...
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Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones
Bioorganic & Medicinal Chemistry Letters, 2008Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.
Okram Mukherjee, Singh +5 more
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