Results 121 to 130 of about 392 (166)
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Dihydropyrimidinones—a new class of anti-Staphylococcal antibiotics
Bioorganic & Medicinal Chemistry Letters, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael, Brands +4 more
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A recent update on the synthesis of dihydropyrimidinones/thiones
AIP Conference Proceedings, 2021Since its development in 1891 Biginelli’s three component synthesis of dihydropyrimidinones/ thiones, it is always on highlight of synthetic organic chemist. A variety of catalysts such as Lewis acid, organocatalyst, Bronsted acid catalyst, ionic liquid catalyst, microwave irradiation methods, ultrasound irradiation methods, grinding and solvent-free ...
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Synthesis and in vitro evaluation of the antifungal activities of dihydropyrimidinones
Bioorganic & Medicinal Chemistry Letters, 2008Copper (II) chloride in the absence of any solvent, efficiently catalyses the synthesis of dihydropyrimidinones (80-96% yields) by the Biginelli reaction. Six compounds were selected and examined their antifungal activities against the radial growth of three fungal species viz., Trichoderma hammatum, Trichoderma koningii and Aspergillus niger.
Okram Mukherjee, Singh +5 more
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Synthesis and anticancer activity of new dihydropyrimidinone derivatives
European Journal of Medicinal Chemistry, 2018A series of dihydropyrimidinone derivatives bearing various N-heterocyclic moieties was designed and synthesized. Twelve new compounds were screened for their cytotoxic activity using 60 cancer cell lines according to NCI (USA) protocol. Compound 19 showed a significant activity against NCI-H460, SK-MEL-5, and HL-60 (TB) cell lines with growth ...
Amany S. Mostafa, Khalid B. Selim
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Asymmetric alkylations of n-acyl dihydropyrimidinones
Tetrahedron: Asymmetry, 1991Abstract Enantiomerically pure dihydropyrimidin-4-one 1 has been employed as a chiral auxiliary for enantioselective alkylation reactions. Acylation of 1 , followed by enolate formation, alkylation and acyl cleavage, affords α-alkylated carboxylic acids in high chemical yield and enatiomeric purity.
George R. Negrete, Joseph P. Konopelski
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One‐Pot Construction of Dihydropyrimidinones in Ionic Liquids.
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Sushilkumar S. Bahekar +2 more
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A chemo- and regio-selective three-component dihydropyrimidinone synthesis
Chemical Communications, 2007A selective three-component coupling, involving co-condensation of aldehyde pairs with substituted ureas under Lewis acid catalysis, provides rapid access to highly functionalised dihydropyrimidinones; sulfamides react analogously.
Chris D, Bailey +4 more
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Biological activity of dihydropyrimidinone (DHPM) derivatives: A systematic review
European Journal of Medicinal Chemistry, 2018Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which, in recent decades, have aroused interest in medicinal chemistry due to alleged versatile biological activity. In this systematic review, we describe the currently published activities of dihydropyrimidinone derivatives.
Larizza Hellen Santana Matos +3 more
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Asymmetric Synthesis of Medicinally Important Dihydropyrimidinones
The Biginelli reaction is considered one of the well-known examples of a multicomponent reaction that is useful in the synthesis of dihydropyrimidinones (DHPMs) using aryl aldehydes, urea, and esters and these are significant compounds in medicinal chemistry and chemical synthesis.Rajni Sharma +2 more
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