Results 1 to 10 of about 392 (169)

Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative [PDF]

Frontiers in Pharmacology, 2021
Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms.
Mingqian Zhou, Yiqi Wang, Xiaoying Lin, Jieping Wan, Chengping Wen   +4 more
doaj   +2 more sources

Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures [PDF]

Beilstein Journal of Organic Chemistry, 2022
A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported.
Sangram Gore, Sundarababu Baskaran, Burkhard König   +2 more
doaj   +2 more sources

A One-Pot Biginelli Synthesis and Characterization of Novel Dihydropyrimidinone Derivatives Containing Piperazine/Morpholine Moiety

Molecules, 2018
Enaminones, 4-methyl-1-[4-(piperazin/morpholin-1-yl) phenyl] pent-2-en-1-one (IIa–b) were synthesized by refluxing 1-[4-(piperazin/morpholin-1-yl) phenyl] ethan-1-one (Ia–b) with dimethylformamide dimethylacetal (DMF–DMA) without any ...
Mashooq Ahmad Bhat, Hazem Ghabbour, Mohamed Al-Omar   +2 more
exaly   +3 more sources

Synthesis and in vivo anti-ulcer evaluation of some novel piperidine linked dihydropyrimidinone derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Dihydropyrimidinone derivatives containing piperidine moiety were synthesised in a good yield. All the compounds were confirmed by elemental analysis and spectral data.
Mashooq Ahmad Bhat, Mohamed Al-Omar, Ahmed Naglah   +2 more
exaly   +2 more sources

Novel Dihydropyrimidinone Derivatives as Potential P-Glycoprotein Modulators [PDF]

ACS Omega, 2022
P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared a series of novel triazole-conjugated dihydropyrimidinones using a synthetic approach that is well suited for obtaining compound libraries ...
Sabera Bijani, Faraz Shaikh, Sheefa Mirza, Shirley Weng In Siu, Nayan Jain, Rakesh Rawal, Nigel G. J. Richards, Anamik Shah, Ashish Radadiya   +8 more
openaire   +3 more sources

Solvothermal Synthesis of Multiple Dihydropyrimidinones at a Time as Inhibitors of Eg5

Molecules, 2021
Solvothermal synthesis of multiple dihydropyrimidinones at a time has been developed in inexpensive and green bio-based solvent lactic acid without any additional catalysts or additives.
Xiao-Qiang Jiang, Shi-Quan Chen, Yan-Fei Liu, Xin-Guang Pan, Dan Chen, Shi-Fan Wang   +5 more
doaj   +3 more sources

DIFFERENT ROUTES FOR THE SYNTHESIS OF BENZALDEHYDE-BASED DIHYDROPYIMIDINONES VIA BIGINELLI REACTION

Jurnal Kimia Riset, 2023
Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli ...
Yan Alamanda Ilfahmi, Arif Fadlan
doaj   +1 more source

Dihydropyrimidinones Against Multiresistant Bacteria

Frontiers in Microbiology, 2022
The increase in bacterial resistance to antimicrobials has led to high morbidity and mortality rates, posing a major public health problem, requiring the discovery of novel antimicrobial substances. The biological samples were identified as the Gram-negative bacilli Acinetobacter baumannii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae,
Marisa Castro Jara, Marisa Castro Jara, Allison Carlos Assunção Silva, Marina Ritter, Adriana Fernandes da Silva, Carolina Lambrecht Gonçalves, Pedro Rassier dos Santos, Luciano Sisconetto Borja, Cláudio Martin Pereira de Pereira, Patrícia da Silva Nascente, Patrícia da Silva Nascente   +10 more
openaire   +3 more sources

Oxidative Dehydrogenation of Dihydropyrimidinones and Dihydropyrimidines [PDF]

Organic Letters, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kana, Yamamoto, Ye Grace, Chen, Frédéric G, Buono   +2 more
openaire   +2 more sources

One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives

Results in Chemistry, 2022
An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed.
Sourav Handique, Priyanka Sharma
doaj   +1 more source