Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative [PDF]
Frontiers in Pharmacology, 2021 Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms.
Mingqian Zhou +4 more
doaj +2 more sources
Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures [PDF]
Beilstein Journal of Organic Chemistry, 2022 A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid–N,N-dimethylurea mixtures is reported.
Sangram Gore +2 more
doaj +2 more sources
Pyromellitic acid grafted to cross-linked LDH by dendritic units: An efficient and recyclable heterogeneous catalyst for green synthesis of 2,3-dihydro quinazoline and dihydropyrimidinones derivatives [PDF]
Heliyon, 2023 In this work, using layered double hydroxide (LDH) inorganic substrate, melamine as binding agent and dendrimer G1 and also pyromellitic acid (PMA) organic catalytic agent a heterogeneous acid catalyst was designed and prepared.
Nastaran Ghanbari, Hossein Ghafuri
doaj +2 more sources
Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]
ChemSusChemKnoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM +3 more
europepmc +2 more sources
Investigation of anti-diabetic potential and molecular simulation studies of dihydropyrimidinone derivatives [PDF]
Frontiers in Endocrinology, 2022 In an attempt to find new targets for α-amylase and α-glucosidase for the treatment of type 2 diabetes mellitus, the present study aims in determining the anti-diabetic potential of synthesized dihydropyrimidinone derivatives.
Umair Ilyas +9 more
doaj +2 more sources
Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties [PDF]
HeliyonObjective: The rise of drug-resistant bacteria, viruses, and fungi has prompted the search for new drugs without cross-resistance to current treatments.
Madiha Kanwal +3 more
doaj +2 more sources
Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents. [PDF]
J Oncol, 2022 The diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an interesting drug target. Because of the high incidence and mortality rate of breast cancer, there is a dire need of discovering new pharmacotherapeutic agents in managing this disease.
Altaf R +8 more
europepmc +2 more sources
Novel Dihydropyrimidinone Derivatives as Potential P-Glycoprotein Modulators. [PDF]
ACS Omega, 2022 P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared a series of novel triazole-conjugated dihydropyrimidinones using a synthetic approach that is well suited for obtaining compound libraries ...
Bijani S +8 more
europepmc +4 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Dihydropyrimidinone derivatives containing piperidine moiety were synthesised in a good yield. All the compounds were confirmed by elemental analysis and spectral data.
Mashooq A Bhat +2 more
exaly +2 more sources
Molecules, 2018 Enaminones, 4-methyl-1-[4-(piperazin/morpholin-1-yl) phenyl] pent-2-en-1-one (IIa–b) were synthesized by refluxing 1-[4-(piperazin/morpholin-1-yl) phenyl] ethan-1-one (Ia–b) with dimethylformamide dimethylacetal (DMF–DMA) without any ...
Mashooq A Bhat +2 more
exaly +3 more sources