Results 31 to 40 of about 392 (169)
Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety
Journal of Chemistry, 2020 A new series of novel Biginelli compounds, 5-benzoyl-substituted phenyl-3,4-dihydropyrimidin-2(1H)-one-1H-isoindole-1,3(2H)-dione (1−10), were synthesized from enaminone, 2-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl}-1H-isoindole-1,3(2H)-dione (IV ...
Mashooq A. Bhat +3 more
doaj +1 more source
Monastrol derivatives: in silico and in vitro cytotoxicity assessments
Research in Pharmaceutical Sciences, 2020 Background and purpose: Cancer is the leading cause of death in today’s world, therefore the efforts to achieve anticancer drugs with higher potency and fewer side effects have always been conducted by researchers in the field of pharmaceutical chemistry.
Zahra Bidram +6 more
doaj +1 more source
Ethyl 4-(3-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Acta Crystallographica Section E, 2010 In the title compound, C14H15BrN2O3, the dihydropyrimidinone ring adopts a boat conformation. In the crystal, adjacent molecules are linked through N—H...O hydrogen bonds forming an R22(8) ring motif and generating a zigzag chain extending in ...
Rajesh G. Kalkhambkar +3 more
doaj +1 more source
Journal of Chemistry, 2021 In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR,
Somaye Karimian +5 more
doaj +1 more source
Journal of Saudi Chemical Society, 2021 A molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents based on a lead molecule (elinafide) is described.
M. Shaheer Malik +12 more
doaj +1 more source
Journal of Chemistry, 2019 Enaminone, (2E)-1-[4-(1H-imidazol-1-yl) phenyl]-4-methylpent-2-en-1-one (II) was synthesized by refluxing 1-[4-(1H-imidazol-1-yl) phenyl] ethan-1-one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent-free condition for 12 hours.
Mashooq Ahmad Bhat +4 more
doaj +1 more source
Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one [PDF]
Journal of Pure and Applied Chemistry Research, 2015 Indonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important ...
Masruri MASRURI, Yuga Adi Pranata
doaj
Ethyl 4-[3,5-bis(trifluoromethyl)phenyl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Acta Crystallographica Section E, 2009 In the title compound, C16H14F6N2O3, the dihydropyrimidinone ring adopts an envelope conformation. In the crystal, molecules are linked by N—H...O and C—H...O hydrogen bonds into a ribbon-like structure along the b axis. In the ribbon,
Hoong-Kun Fun +3 more
doaj +1 more source
Ethyl 6-methyl-3-(2-methylprop-1-enyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Acta Crystallographica Section E, 2011 In the molecule of the title compound, C18H22N2O3, the dihydropyrimidinone ring adopts an envelope conformation. The dihedral angle between the phenyl ring and the mean plane through the enamine fragment is 86.04 (7)°.
Xi-Cun Wang +4 more
doaj +1 more source
A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV
Archiv der Pharmazie, Volume 359, Issue 4, April 2026.This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite +11 more
wiley +1 more source