Results 31 to 40 of about 1,000 (202)

One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor [PDF]

, 2013
The Bohlmann–Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. In the Bohlmann–Rahtz reaction, the use
Bagley, Mark C, Fusillo, Vincenzo, Jenkins, Robert L, Lubinu, M Caterina, Mason, Christopher   +4 more
core   +2 more sources

Synthesis of Quinazolin‐2,4,6‐triamine Derivatives as Non‐purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**

ChemMedChem, Volume 18, Issue 20, October 17, 2023., 2023
One quinazolin‐2,4,6‐triamine derivative was found to be a better bovine xanthine oxidase (bXO) inhibitor than allopurinol. Three quinazoline derivatives were not micronuclei inducers in a murine model. Three quinazolin‐2,4,6‐triamine derivatives acted as superoxide scavengers, and one 5,6‐dihydro‐3H‐pirimidin‐4‐one showed bXO inhibitory activity ...
Marcela A. Lopez‐Sanchez, María del Carmen Garcia‐Rodriguez, Rodrigo Aguayo‐Ortiz, Estefani Hernandez‐Cruz, Diego I. Figueroa‐Figueroa, Francisco Hernandez‐Luis   +5 more
wiley   +1 more source

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum [PDF]

, 2009
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle.
Annette N. Chiang, Banumathy, Billy W. Day, Botha, Brian P. Mead, Chiu, Corinne Schneider, Craig, David A. Fidock, Donna M. Huryn, Ekland, Fernandez-Saiz, Fewell, Fewell, Fewell, Fidock, Frydman, Hartl, Hunt, Jeffrey L. Brodsky, Jiang, Juan-Carlos Valderramos, Maier, Matambo, Mayer, McClellan, McKerrow, Michael G. Klein, Midorikawa, Nadeau, Noedl, Pavithra, Pecoul, Peter Wipf, Raghavan Balachandran, Raj J. Chovatiya, Ramya, Rodina, Samantha L. Bell, Shonhai, Shonhai, Sidhu, Tang, Tonkin, Wellems, Werner, Wright, Xiaojiang S. Chen, Youker   +48 more
core   +1 more source

Antioxidant Compounds in the Treatment of Alzheimer’s Disease: Natural, Hybrid, and Synthetic Products

Evidence-Based Complementary and Alternative Medicine, Volume 2023, Issue 1, 2023., 2023
Alzheimer’s disease (AD) which is associated with cognitive dysfunction and memory lapse has become a health concern. Various targets and pathways have been involved in AD’s progress, such as deficit of acetylcholine (ACh), oxidative stress, inflammation, β‐amyloid (Aβ) deposits, and biometal dyshomeostasis.
Maryam Hatami, Mojtaba Mortazavi, Zahra Baseri, Batool Khani, Mehdi Rahimi, Sahar Babaei, Duygu Ağagündüz   +6 more
wiley   +1 more source

5-Acetyl-4-(2,5-dimethoxyphenyl)-6-methyl-1-(prop-2-ynyl)-3,4-dihydropyrimidin-2(1H)-one

IUCrData, 2017
In the title compound, C18H20N2O4, the 3,4-dihydropyrimidin-2(1H)-one ring has a screw-boat conformation. The mean plane through this heterocycle is almost perpendicular to the prop-2-ynyl chain and to the benzene ring, with which it makes a dihedral ...
Hanane Kaoukabi, Moha Taourirte, Mohamed El Azhari, Hassan B. Lazrek, Mohamed Saadi, Lahcen El Ammari   +5 more
doaj   +1 more source

Structure of human TRPM8 channel [PDF]

, 2022
TRPM8 is a calcium ion channel that is activated by multiple factors, such as temperature, voltage, pressure, and osmolality. It is a therapeutic target for anticancer drug development, and its modulators can be utilized for several pathological ...
Beccari, Andrea R., Czarnocki-Cieciura, Mariusz, Gervasoni, Silvia, Nowak, Elżbieta, Nowotny, Marcin, Palchevskyi, Sergii, Talarico, Carmine, Vistoli, Giulio   +7 more
core   +2 more sources

Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions

ChemSusChem, Volume 15, Issue 17, September 7, 2022., 2022
Mission impossible: Mechanosynthesis is erroneously perceived as an enabling tool for only making greener well‐known solution‐based processes. Modern mechanochemistry is, above all, an effective tool to open synthetic paths not accessible by following conventional and well‐known pathways already reported in the literature for the classical chemistry in
Federico Cuccu, Lidia De Luca, Francesco Delogu, Evelina Colacino, Niclas Solin, Rita Mocci, Andrea Porcheddu   +6 more
wiley   +1 more source

N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis [PDF]

, 2016
Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU “Substances of Very High Concern” list ...
Farmer, Thomas James, Hunt, Andrew John, Moonen, Kristof, Parker, Helen Louise, Sherwood, James Richard   +4 more
core   +1 more source

Sono-thermal oxidation of dihydropyrimidinones

Ultrasonics Sonochemistry, 2008
Combination of ultrasound and heat has been used for the oxidation of some ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates to their corresponding ethyl pyrimidin-2(1H)-one-5-carboxylates by using potassium peroxydisulfate in aqueous acetonitrile. An ultrasonic probe of 24 kHz frequency has been used for this study.
Hamid Reza, Memarian, Asadollah, Farhadi
openaire   +2 more sources

Activity of RX-04 Pyrrolocytosine Protein Synthesis Inhibitors against Multidrug-Resistant Gram-Negative Bacteria [PDF]

, 2018
Pyrrolocytosines RX-04A-D are designed to bind to the bacterial 50S ribosomal subunit differently from currently-used antibiotics. The four analogs had broad anti-Gram-negative activity: RX-04A inhibited 94.7% of clinical Enterobacteriaceae ...
Doumith, Michel, Livermore, David M, Mushtaq, Shazad, Vickers, Anna, Woodford, Neil   +4 more
core   +1 more source