Results 31 to 40 of about 611 (196)

Synthesis of Quinazolin‐2,4,6‐triamine Derivatives as Non‐purine Xanthine Oxidase Inhibitors and Exploration of Their Toxicological Potential**

ChemMedChem, Volume 18, Issue 20, October 17, 2023., 2023
One quinazolin‐2,4,6‐triamine derivative was found to be a better bovine xanthine oxidase (bXO) inhibitor than allopurinol. Three quinazoline derivatives were not micronuclei inducers in a murine model. Three quinazolin‐2,4,6‐triamine derivatives acted as superoxide scavengers, and one 5,6‐dihydro‐3H‐pirimidin‐4‐one showed bXO inhibitory activity ...
Marcela A. Lopez‐Sanchez, María del Carmen Garcia‐Rodriguez, Rodrigo Aguayo‐Ortiz, Estefani Hernandez‐Cruz, Diego I. Figueroa‐Figueroa, Francisco Hernandez‐Luis   +5 more
wiley   +1 more source

Efficient synthesis of the optically active dihydropyrimidinone of a potent α_1A- selective adrenoceptor antagonist [PDF]

, 2002
The convergent synthesis of a potent α1A-selective adrenoceptor antagonist is described. Salient features of the synthesis include the enzymatic resolution of a racemic dihydropyrimidinone and the use of a palladium coupling reaction in the synthesis of
Michel Chartrain, Nancy Barta, Wenjie Li, Robert D Larsen, Edward G Corley, Nori Ikemoto, Louis Matty, Kozo Gbewonyo, Paul J Reider, Jeffrey S Campbell, Russell Boyd, Richard G Ball, Daniel R Sidler, Essa Hu   +13 more
core   +1 more source

Antioxidant Compounds in the Treatment of Alzheimer’s Disease: Natural, Hybrid, and Synthetic Products

Evidence-Based Complementary and Alternative Medicine, Volume 2023, Issue 1, 2023., 2023
Alzheimer’s disease (AD) which is associated with cognitive dysfunction and memory lapse has become a health concern. Various targets and pathways have been involved in AD’s progress, such as deficit of acetylcholine (ACh), oxidative stress, inflammation, β‐amyloid (Aβ) deposits, and biometal dyshomeostasis.
Maryam Hatami, Mojtaba Mortazavi, Zahra Baseri, Batool Khani, Mehdi Rahimi, Sahar Babaei, Duygu Ağagündüz   +6 more
wiley   +1 more source

5-Acetyl-4-(2,5-dimethoxyphenyl)-6-methyl-1-(prop-2-ynyl)-3,4-dihydropyrimidin-2(1H)-one

IUCrData, 2017
In the title compound, C18H20N2O4, the 3,4-dihydropyrimidin-2(1H)-one ring has a screw-boat conformation. The mean plane through this heterocycle is almost perpendicular to the prop-2-ynyl chain and to the benzene ring, with which it makes a dihedral ...
Hanane Kaoukabi, Moha Taourirte, Mohamed El Azhari, Hassan B. Lazrek, Mohamed Saadi, Lahcen El Ammari   +5 more
doaj   +1 more source

Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions

ChemSusChem, Volume 15, Issue 17, September 7, 2022., 2022
Mission impossible: Mechanosynthesis is erroneously perceived as an enabling tool for only making greener well‐known solution‐based processes. Modern mechanochemistry is, above all, an effective tool to open synthetic paths not accessible by following conventional and well‐known pathways already reported in the literature for the classical chemistry in
Federico Cuccu, Lidia De Luca, Francesco Delogu, Evelina Colacino, Niclas Solin, Rita Mocci, Andrea Porcheddu   +6 more
wiley   +1 more source

Sono-thermal oxidation of dihydropyrimidinones

Ultrasonics Sonochemistry, 2008
Combination of ultrasound and heat has been used for the oxidation of some ethyl 3,4-dihydropyrimidin-2(1H)-one-5-carboxylates to their corresponding ethyl pyrimidin-2(1H)-one-5-carboxylates by using potassium peroxydisulfate in aqueous acetonitrile. An ultrasonic probe of 24 kHz frequency has been used for this study.
Hamid Reza, Memarian, Asadollah, Farhadi
openaire   +2 more sources

Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity [PDF]

, 2021
Seven novel azo dyes with 2-pyridone and dihydropyrimidinone moieties have been synthesized and thoroughly characterized. The azo-hydrazone tautomerism has been investigated by experimental and theoretical approaches.
Vitnik, Zeljko J., Matić, Ivana Z., Stanojković, Tatjana, Vitnik, Vesna D., Tadić, Julijana D., Mijin, Dušan, Vitnik, Vesna, Mijin, Dušan Ž., Vitnik, Željko, Tadić, Julijana, Lađarević, Jelena M., Lađarević, Jelena, Stanojkovic, Tatjana P.   +12 more
core   +1 more source

Synthesis of dihydropyrimidinone (DHPM) derivatives through a multicomponent reaction (MCR) and their biological activity [PDF]

, 2023
The spread of incurable diseases, especially infectious diseases caused by antibiotic-resistant bacteria and certain cancers, has become a serious public health concern.
Saifudin, Azis, Rullah, Kamal, Fauzi, Ahmad   +2 more
core   +1 more source

Efficient synthesis of dihydropyrimidinones via a three-component Biginelli-type reaction of urea, alkylaldehyde and arylaldehyde

Beilstein Journal of Organic Chemistry, 2013
A one-pot three-component synthesis of dihydropyrimidinones via a molecular iodine-catalyzed tandem reaction of simple readily available mono-substituted urea, alkylaldehyde, and arylaldehyde has been developed. The reaction proceeds with high chemo- and
Haijun Qu, Xuejian Li, Fan Mo, Xufeng Lin   +3 more
doaj   +1 more source

Ultrasound-Assisted Synthesis of Novel 4-(2-Phenyl-1,2,3-Triazol-4-yl)-3,4-Dihydropyrimidin-2(1H)-(Thio)ones Catalyzed by Sm(ClO4)3

Molecules, 2010
An efficient synthesis of novel 4-(2-phenyl-1,2,3-triazol-4-yl)-3,4-dihydro-pyrimidin-2(1H)-(thio)ones from 1,3-dicarbonyl compounds, 2-phenyl-1,2,3-triazole-4-carbaldehyde and urea or thiourea under ultrasound irradiation and using samarium perchlorate ...
Ji-De Wang, Chen-Jiang Liu
doaj   +1 more source