Results 11 to 20 of about 611 (196)

Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids Against Cholinesterases: In Silico, In Vitro, and In Vivo Studies [PDF]

International Journal of Molecular Sciences
Combining the pharmacological properties of the 1,2,3-triazole and dihydropyrimidinone classes of compounds, two small families of mono- and di(1,2,3-triazole)-dihydropyrimidinone hybrids, A and B, were previously synthesized.
CARLOS M Gastalho, Ana M Sena, OSCAR Lopez   +2 more
exaly   +7 more sources

DIFFERENT ROUTES FOR THE SYNTHESIS OF BENZALDEHYDE-BASED DIHYDROPYIMIDINONES VIA BIGINELLI REACTION [PDF]

Jurnal Kimia Riset, 2023
Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli ...
Yan Alamanda Ilfahmi, Arif Fadlan
doaj   +3 more sources

Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety [PDF]

Journal of Chemistry, 2020
A new series of novel Biginelli compounds, 5-benzoyl-substituted phenyl-3,4-dihydropyrimidin-2(1H)-one-1H-isoindole-1,3(2H)-dione (1−10), were synthesized from enaminone, 2-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl}-1H-isoindole-1,3(2H)-dione (IV ...
Mashooq A. Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Abdullah Al-Dhfyan   +3 more
doaj   +2 more sources

Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety [PDF]

Journal of Chemistry, 2019
Enaminone, (2E)-1-[4-(1H-imidazol-1-yl) phenyl]-4-methylpent-2-en-1-one (II) was synthesized by refluxing 1-[4-(1H-imidazol-1-yl) phenyl] ethan-1-one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent-free condition for 12 hours.
Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Atef Kalmouch, Abdullah Al-Dhfyan   +4 more
doaj   +2 more sources

Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors [PDF]

Journal of Chemistry, 2021
In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR,
Somaye Karimian, Yasaman Moghdani, Mahsima Khoshneviszadeh, Somayeh Pirhadi, Aida Iraji, Mehdi Khoshneviszadeh   +5 more
doaj   +2 more sources

Molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents [PDF]

Journal of Saudi Chemical Society, 2021
A molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents based on a lead molecule (elinafide) is described.
M. Shaheer Malik, Syed Farooq Adil, Zaki S. Seddigi, Moataz Morad, Rabab S. Jassas, Ismail I. Thagafi, Hatem M. Altass, Qazi Mohammad Sajid Jamal, Syed Riyaz, Reem I. Alsantali, Abdulrahman A. Al-Warthan, Mohammad Azam Ansari, Saleh A. Ahmed   +12 more
doaj   +2 more sources

New Anticancer 4-Aryldihydropyrimidinone-5-Carboxylates Targeting Hsp90. [PDF]

Chem Biol Drug Des
We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Bordoni C, Elstow TZ, Brancale A, Clarkson RWE, Westwell AD.   +4 more
europepmc   +2 more sources

DES-Promoted Synthesis of 3,4-Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies. [PDF]

Chem Biodivers
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Kumar G, Mishra S, Seboletswe P, Gcabashe N, Gummidi L, Manhas N, Makhanya T, Bhargava G, Idris A, Islam MS, Singh P.   +10 more
europepmc   +2 more sources

Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound. [PDF]

Adv Healthc Mater
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Zeng Q, Du S, Yuan R, Zeng Y, Li X, Wu YW, Chen K, Tao L, Tang Z, Deng X.   +9 more
europepmc   +2 more sources

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane [PDF]

Drug Design, Development and Therapy, 2019
Mashooq Ahmad Bhat,1 Mohamed A Al-Omar,1 Azmat Ali Khan,1 Amer M Alanazi,1 Ahmed M Naglah2,31Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutical Chemistry, Drug ...
Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM   +4 more
doaj   +2 more sources