Results 11 to 20 of about 680 (195)

Novel Dihydropyrimidinone Derivatives as Potential P-Glycoprotein Modulators [PDF]

ACS Omega, 2022
P-glycoprotein (Pgp), an ATP binding cassette (ABC) transporter, is an ATP-dependent efflux pump responsible for cancer multidrug resistance. As part of efforts to identify human Pgp (hPgp) inhibitors, we prepared a series of novel triazole-conjugated dihydropyrimidinones using a synthetic approach that is well suited for obtaining compound libraries ...
Sabera Bijani, Faraz Shaikh, Sheefa Mirza, Shirley Weng In Siu, Nayan Jain, Rakesh Rawal, Nigel G. J. Richards, Anamik Shah, Ashish Radadiya   +8 more
core   +5 more sources

Assessing the Potential of 1,2,3-Triazole-Dihydropyrimidinone Hybrids Against Cholinesterases: In Silico, In Vitro, and In Vivo Studies [PDF]

International Journal of Molecular Sciences
Combining the pharmacological properties of the 1,2,3-triazole and dihydropyrimidinone classes of compounds, two small families of mono- and di(1,2,3-triazole)-dihydropyrimidinone hybrids, A and B, were previously synthesized.
Elisabete P. Carreiro, Anthony J. Burke, Celia Antunes   +2 more
exaly   +5 more sources

DIFFERENT ROUTES FOR THE SYNTHESIS OF BENZALDEHYDE-BASED DIHYDROPYIMIDINONES VIA BIGINELLI REACTION [PDF]

Jurnal Kimia Riset, 2023
Multicomponent reactions involving three or more reactants are commonly used to prepare dihydropyrimidinone with various bioactivities. This study reports the different routes for the synthesis of benzaldehyde-based dihydropyrimidinone via the Biginelli ...
Yan Alamanda Ilfahmi, Arif Fadlan
doaj   +3 more sources

Biginelli Synthesis of Novel Dihydropyrimidinone Derivatives Containing Phthalimide Moiety

Journal of Chemistry, 2020
A new series of novel Biginelli compounds, 5-benzoyl-substituted phenyl-3,4-dihydropyrimidin-2(1H)-one-1H-isoindole-1,3(2H)-dione (1−10), were synthesized from enaminone, 2-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl}-1H-isoindole-1,3(2H)-dione (IV ...
Mashooq A. Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Abdullah Al-Dhfyan   +3 more
doaj   +2 more sources

Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety

Journal of Chemistry, 2019
Enaminone, (2E)-1-[4-(1H-imidazol-1-yl) phenyl]-4-methylpent-2-en-1-one (II) was synthesized by refluxing 1-[4-(1H-imidazol-1-yl) phenyl] ethan-1-one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent-free condition for 12 hours.
Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Atef Kalmouch, Abdullah Al-Dhfyan   +4 more
doaj   +2 more sources

Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors

Journal of Chemistry, 2021
In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR,
Somaye Karimian, Yasaman Moghdani, Mahsima Khoshneviszadeh, Somayeh Pirhadi, Aida Iraji, Mehdi Khoshneviszadeh   +5 more
doaj   +2 more sources

Molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents

Journal of Saudi Chemical Society, 2021
A molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents based on a lead molecule (elinafide) is described.
M. Shaheer Malik, Syed Farooq Adil, Zaki S. Seddigi, Moataz Morad, Rabab S. Jassas, Ismail I. Thagafi, Hatem M. Altass, Qazi Mohammad Sajid Jamal, Syed Riyaz, Reem I. Alsantali, Abdulrahman A. Al-Warthan, Mohammad Azam Ansari, Saleh A. Ahmed   +12 more
doaj   +2 more sources

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
International audienceA new series of isoniazid‐dihydropyrimidinone molecular hybrids ( 8a – 8n ) were designed, synthesized and structurally characterized using different spectroscopic techniques viz., Fourier transform infrared spectroscopy, nuclear ...
Kerru, Nagaraju, Foubert, Maëlle, Kumar, Gobind, Seboletswe, Pule, Ghumran, Safiyah, Kremer, Laurent, Bhargava, Gaurav, Mishra, Sahil, Manhas, Neha, Singh, Parvesh, Roquet-Banères, Françoise   +10 more
core   +2 more sources

Development of Dithioacetal-Modified Dihydropyrimidone Derivatives with Potential Anti-Inflammatory Activity for Inflammatory Bowel Disease. [PDF]

Chem Biodivers
This study designed and synthesized dithioacetal‐modified dihydropyrimidinone derivatives (30). Compound D3 showed optimal anti‐inflammatory activity, inhibiting the MAPK/NF‐κB pathway, reducing NO secretion (IC50 = 1.2 µM), and ameliorating DSS‐induced acute colitis in mice, offering a new candidate for inflammatory bowel disease therapy.
Jiang JW, Dong R, Cao Q, Wang H, Li SY, Zhang GP, Wang QY.   +6 more
europepmc   +2 more sources

Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients. [PDF]

ChemSusChem
Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Chatzigiannis CM, Scalzullo SM, Colacino E, Rivas ME.   +3 more
europepmc   +2 more sources