Multigram‐Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients [PDF]
ChemSusChem, Volume 18, Issue 13, July 1, 2025.Knoevenagel condensation, Biginelli three‐component reaction and benzylic rearrangement are investigated at multi‐gram scale, by resonance acoustic mixing (RAM), to prepare biologically active molecules, also including the marketed Phenytoin (antiepileptic drug). Chem21 and DOZN 3.0 tools were used to assess the greenness of the RAM‐assisted syntheses,
Christos M. Chatzigiannis +3 more
wiley +2 more sources
Pyromellitic acid grafted to cross-linked LDH by dendritic units: An efficient and recyclable heterogeneous catalyst for green synthesis of 2,3-dihydro quinazoline and dihydropyrimidinones derivatives [PDF]
Heliyon, 2023 In this work, using layered double hydroxide (LDH) inorganic substrate, melamine as binding agent and dendrimer G1 and also pyromellitic acid (PMA) organic catalytic agent a heterogeneous acid catalyst was designed and prepared.
Nastaran Ghanbari, Hossein Ghafuri
doaj +2 more sources
DES‐Promoted Synthesis of 3,4‐Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies [PDF]
Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Gobind Kumar +10 more
wiley +2 more sources
New Anticancer 4‐Aryldihydropyrimidinone‐5‐Carboxylates Targeting Hsp90 [PDF]
Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Cinzia Bordoni +4 more
wiley +2 more sources
Investigation of anti-diabetic potential and molecular simulation studies of dihydropyrimidinone derivatives [PDF]
Frontiers in Endocrinology, 2022 In an attempt to find new targets for α-amylase and α-glucosidase for the treatment of type 2 diabetes mellitus, the present study aims in determining the anti-diabetic potential of synthesized dihydropyrimidinone derivatives.
Umair Ilyas +9 more
doaj +2 more sources
Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties [PDF]
HeliyonObjective: The rise of drug-resistant bacteria, viruses, and fungi has prompted the search for new drugs without cross-resistance to current treatments.
Madiha Kanwal +3 more
doaj +2 more sources
Self‐Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound [PDF]
Advanced Healthcare Materials, Volume 14, Issue 11, April 25, 2025.High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Qiang Zeng +9 more
wiley +2 more sources
Human transforming growth factor β type I receptor in complex with kinase inhibitor SB505124 [PDF]
Acta Crystallographica Section F, Volume 80, Issue 11, Page 314-319, November 2024.This study presents the crystal structure of transforming growth factor β type I receptor (TβR1) in complex with SB505124, highlighting the specific contacts that SB505124 makes with TβR1 and comparing these interactions with those of SB431542.The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in ...
Jhon A. Rodriguez Buitrago +2 more
wiley +2 more sources
Magnetic polymeric ionic liquid for both catalysis application and magnetic solid phase extraction approach [PDF]
Scientific ReportsIn this project, a new heterogeneous polymeric ionic liquid catalyst based on vinylimidazole, stabilized on magnetic nanoparticles )Fe3O4@Al2O3@[PBVIm]HSO4) was prepared.
Behrooz Maleki +4 more
doaj +2 more sources
ChemMedChem, Volume 18, Issue 20, October 17, 2023., 2023 One quinazolin‐2,4,6‐triamine derivative was found to be a better bovine xanthine oxidase (bXO) inhibitor than allopurinol. Three quinazoline derivatives were not micronuclei inducers in a murine model. Three quinazolin‐2,4,6‐triamine derivatives acted as superoxide scavengers, and one 5,6‐dihydro‐3H‐pirimidin‐4‐one showed bXO inhibitory activity ...
Marcela A. Lopez‐Sanchez +5 more
wiley +1 more source