Results 11 to 20 of about 1,000 (202)

Synthesis of 3,4-Dihydropyrimidin(thio)one Containing Scaffold: Biginelli-like Reactions. [PDF]

Pharmaceuticals (Basel), 2022
The interest in 3,4-dihydropyrimidine-2(1H)-(thio)ones is increasing every day, mainly due to their paramount biological relevance. The Biginelli reaction is the classical approach to reaching these scaffolds, although the product diversity suffers from ...
Sánchez-Sancho F, Escolano M, Gaviña D, Csáky AG, Sánchez-Roselló M, Díaz-Oltra S, Del Pozo C.   +6 more
europepmc   +3 more sources

Synthesis and in vivo anti-ulcer evaluation of some novel piperidine linked dihydropyrimidinone derivatives

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Dihydropyrimidinone derivatives containing piperidine moiety were synthesised in a good yield. All the compounds were confirmed by elemental analysis and spectral data.
Mashooq A Bhat, Mohamed A Al-Omar, Ahmed M NaglaH   +2 more
exaly   +2 more sources

A One-Pot Biginelli Synthesis and Characterization of Novel Dihydropyrimidinone Derivatives Containing Piperazine/Morpholine Moiety

Molecules, 2018
Enaminones, 4-methyl-1-[4-(piperazin/morpholin-1-yl) phenyl] pent-2-en-1-one (IIa–b) were synthesized by refluxing 1-[4-(piperazin/morpholin-1-yl) phenyl] ethan-1-one (Ia–b) with dimethylformamide dimethylacetal (DMF–DMA) without any ...
Mashooq A Bhat, Mohamed A Al-Omar, Hazem A Ghabbour   +2 more
exaly   +3 more sources

New Anticancer 4-Aryldihydropyrimidinone-5-Carboxylates Targeting Hsp90. [PDF]

Chem Biol Drug Des
We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Bordoni C, Elstow TZ, Brancale A, Clarkson RWE, Westwell AD.   +4 more
europepmc   +2 more sources

DES-Promoted Synthesis of 3,4-Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies. [PDF]

Chem Biodivers
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Kumar G, Mishra S, Seboletswe P, Gcabashe N, Gummidi L, Manhas N, Makhanya T, Bhargava G, Idris A, Islam MS, Singh P.   +10 more
europepmc   +2 more sources

Synthesis of some dihydropyrimidinone derivatives and study of their anti-inflammatory activity [PDF]

Journal of Applied Pharmaceutical Research, 2018
This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen containing compounds, such as quinazolines, indoles, benzimidazole, quinoxalines, coumarins and pyrimidines etc. A mixture of substituted aldehydes
Naresh Podilla, Tirthankar Choudhury
doaj   +4 more sources

Self-Healing Hydrogel Dressing with Solubilized Flavonoids for Whole Layer Regeneration of Diabetic Wound. [PDF]

Adv Healthc Mater
High glucose‐ and acid‐responsive hydrogel with dynamic covalent bond solubilized with flavonoids (Gel‐Flavonoids) is designed for diabetic wound healing. The Gel‐Flavonoids adapt to irregular wound shapes and release antioxidants in high‐glucose environments, effectively reducing reactive oxygen species.
Zeng Q, Du S, Yuan R, Zeng Y, Li X, Wu YW, Chen K, Tao L, Tang Z, Deng X.   +9 more
europepmc   +2 more sources

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane [PDF]

Drug Design, Development and Therapy, 2019
Mashooq Ahmad Bhat,1 Mohamed A Al-Omar,1 Azmat Ali Khan,1 Amer M Alanazi,1 Ahmed M Naglah2,31Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutical Chemistry, Drug ...
Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM   +4 more
doaj   +2 more sources

Magnetic polymeric ionic liquid for both catalysis application and magnetic solid phase extraction approach [PDF]

Scientific Reports
In this project, a new heterogeneous polymeric ionic liquid catalyst based on vinylimidazole, stabilized on magnetic nanoparticles )Fe3O4@Al2O3@[PBVIm]HSO4) was prepared.
Behrooz Maleki, Reza Sandaroos, Fahimeh Yousefi, Milad Ghani, Sahar Peiman   +4 more
doaj   +2 more sources

Exploring dihydropyrimidone derivatives as modulators of carbohydrate catabolic enzyme to mitigate diabetes. [PDF]

Sci Rep
Diabetes is a prevalent and serious metabolic disorder affecting millions globally, and it poses extensive health risks due to elevated blood glucose levels.
Ali SP, Mansoor F, Albaayit SFA, Ali F, Dera AA, Shahbaz M, Ullah J, Almohaimeed HM, Gahtani RM, Abdulfattah AM, Alshabrmi FM, Alam S, Ullah S.   +12 more
europepmc   +3 more sources