Results 41 to 50 of about 680 (195)

Monastrol derivatives: in silico and in vitro cytotoxicity assessments

Research in Pharmaceutical Sciences, 2020
Background and purpose: Cancer is the leading cause of death in today’s world, therefore the efforts to achieve anticancer drugs with higher potency and fewer side effects have always been conducted by researchers in the field of pharmaceutical chemistry.
Zahra Bidram, Hajar Sirous, Ghadam Ali Khodarahmi, Farshid Hassanzadeh, Nasim Dana, Amir Ali Hariri, Mahboubeh Rostami   +6 more
doaj   +1 more source

Evaluation of anticancer and antimicrobial activities of novel dihydropyrimidinone derivatives [PDF]

Dihydropyrimidinone (DHPM) can be synthesized through a simple one-pot Biginelli reaction. Off-late medicinal properties of DHPM have been discovered. In our recent work, we have shown that the florescent property can be appended to this molecule while ...
Thangamani, Suppan, Moorthi, Pichumani, KALLOL, MOHANTA, Sankarganesh, Jeyaraj, RamaRanjan, Bhattacharjee   +4 more
core   +1 more source

Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one [PDF]

Journal of Pure and Applied Chemistry Research, 2015
Indonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important ...
Masruri MASRURI, Yuga Adi Pranata
doaj  

Ethyl 4-[3,5-bis(trifluoromethyl)phenyl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
In the title compound, C16H14F6N2O3, the dihydropyrimidinone ring adopts an envelope conformation. In the crystal, molecules are linked by N—H...O and C—H...O hydrogen bonds into a ribbon-like structure along the b axis. In the ribbon,
Hoong-Kun Fun, Ching Kheng Quah, M. Babu, B. Kalluraya   +3 more
doaj   +1 more source

Ethyl 6-methyl-3-(2-methylprop-1-enyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2011
In the molecule of the title compound, C18H22N2O3, the dihydropyrimidinone ring adopts an envelope conformation. The dihedral angle between the phenyl ring and the mean plane through the enamine fragment is 86.04 (7)°.
Xi-Cun Wang, Xue-Hong Tang, Yu-Xia Da, Zhang Zhang, Zheng-Jun Quan   +4 more
doaj   +1 more source

Evaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza, Flávia Suelen De O. Pereira, Daniela Teixeira Rodrigues, Helder Dias Costa, Tarsila Dantas Da Rosa, Camila Machado Pires da Silva, Gilsane von Poser, Stela M. K. Rates, Favero R. Paula, Daiana Silva Ávila   +9 more
wiley   +1 more source

An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones

E-Journal of Chemistry, 2008
The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)2, as a recycling catalyst, from a diversity of aromatic aldehydes, β ...
Taoues Boumoud, Boudjemaa Boumoud, Salah Rhouati, Ali Belfaitah, Abdelmadjid Debache, Paul Mosset   +5 more
doaj   +1 more source

Ethyl 4-(2,4-difluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
In the title compound, C14H14F2N2O3, the dihydropyrimidinone ring adopts a flattened boat conformation. The difluorophenyl group is disordered over two orientations with occupancies of 0.544 (3) and 0.456 (3).
Hoong-Kun Fun, Chin Sing Yeap, M. Babu, B. Kalluraya   +3 more
doaj   +1 more source

Antibacterial Studies of Dihydropyrimidinones and Pyrimidinethiones [PDF]

Journal of Bacteriology & Mycology: Open Access, 2017
Some new dihydro pyrimidinone and pyrimidinethione compounds have been synthesized and their antibacterial activities have been studied in dimethyl formamide and dimethyl sulphoxide against some Gram positive and Gram negative bacteria For this Agar well diffusion method is used It is observed that inhibition depends on solvent bacterial strain ...
openaire   +1 more source

Topology-Controlled Selective Fe³⁺ Binding in Water by δ‑Peptides with a Dihydropyrimidinone-Containing Amino Acid

, 2020
The effect of topology on the structure, self-assembly, and selective Fe3+ binding of δ-peptides has been investigated. A series of δ-peptides with an amino acid containing dihydropyrimidinone and o-, m-, and p-aminobenzoic acids have been designed to ...
Pradip Kumar Ghorai, Sukanya Konar, Debasish Haldar, Supriya Sasmal (6649376), Debasish Podder, Debasish Podder (5612660), Sukanya Konar (6887798), Supriya Sasmal, Pradip Kumar Ghorai (8399769), Debasish Haldar (1769383)   +9 more
core   +1 more source