Results 51 to 60 of about 1,000 (202)

Ethyl 4-(3-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2010
In the title compound, C14H15BrN2O3, the dihydropyrimidinone ring adopts a boat conformation. In the crystal, adjacent molecules are linked through N—H...O hydrogen bonds forming an R22(8) ring motif and generating a zigzag chain extending in ...
Rajesh G. Kalkhambkar, Haldorai Yuvaraj, D. Velmurugan, S. Sundaramoorthy   +3 more
doaj   +1 more source

Rational Design, Synthesis, In Vitro, and In Silico Studies of Dihydropyrimidinone Derivatives as β-Glucuronidase Inhibitors

Journal of Chemistry, 2021
In the current study, a series of dihydropyrimidinone derivatives were rationally designed as β-glucuronidase inhibitors. These designed compounds were successfully synthesized and characterized through various spectroscopic techniques such as IR, 1H-NMR,
Somaye Karimian, Yasaman Moghdani, Mahsima Khoshneviszadeh, Somayeh Pirhadi, Aida Iraji, Mehdi Khoshneviszadeh   +5 more
doaj   +1 more source

Molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents

Journal of Saudi Chemical Society, 2021
A molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents based on a lead molecule (elinafide) is described.
M. Shaheer Malik, Syed Farooq Adil, Zaki S. Seddigi, Moataz Morad, Rabab S. Jassas, Ismail I. Thagafi, Hatem M. Altass, Qazi Mohammad Sajid Jamal, Syed Riyaz, Reem I. Alsantali, Abdulrahman A. Al-Warthan, Mohammad Azam Ansari, Saleh A. Ahmed   +12 more
doaj   +1 more source

Antibacterial Studies of Dihydropyrimidinones and Pyrimidinethiones [PDF]

Journal of Bacteriology & Mycology: Open Access, 2017
Some new dihydro pyrimidinone and pyrimidinethione compounds have been synthesized and their antibacterial activities have been studied in dimethyl formamide and dimethyl sulphoxide against some Gram positive and Gram negative bacteria For this Agar well diffusion method is used It is observed that inhibition depends on solvent bacterial strain ...
openaire   +1 more source

Synthesis and Characterization of Novel Biginelli Dihydropyrimidinone Derivatives Containing Imidazole Moiety

Journal of Chemistry, 2019
Enaminone, (2E)-1-[4-(1H-imidazol-1-yl) phenyl]-4-methylpent-2-en-1-one (II) was synthesized by refluxing 1-[4-(1H-imidazol-1-yl) phenyl] ethan-1-one (I) with dimethylforamide dimethylacetal (DMF–DMA) under solvent-free condition for 12 hours.
Mashooq Ahmad Bhat, Mohamed A. Al-Omar, Ahmed M. Naglah, Atef Kalmouch, Abdullah Al-Dhfyan   +4 more
doaj   +1 more source

EFFICIENT SODIUM SELENATE-CATALYZED SYNTHESIS OF 3,4-DIHYDRO-2(1H)-PYRIMIDINONES AND –THIONES UNDER SOLVENT-FREE CONDITIONS [PDF]

, 2009
Sodium selenate efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a,β-keto ester and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or –thiones in excellent ...
Baghernejad, Bita, Heidari, Maryam, Hekmatshoar, Rahim, M. Heravi, Majid   +3 more
core   +2 more sources

A Bifunctional Metal/Acid Catalyst for One-Pot Multistep Synthesis of Pharmaceuticals [PDF]

, 2020
[EN] One inhibitor of the fatty acid transporter FATP4 was synthesized in a three steps one-pot process in the presence of a bifunctional metal/acid catalyst.
Corma Canós, Avelino, López Prado, Mª Victoria, Sabater Picot, Mª José   +2 more
core   +1 more source

Ethyl 4-[3,5-bis(trifluoromethyl)phenyl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
In the title compound, C16H14F6N2O3, the dihydropyrimidinone ring adopts an envelope conformation. In the crystal, molecules are linked by N—H...O and C—H...O hydrogen bonds into a ribbon-like structure along the b axis. In the ribbon,
Hoong-Kun Fun, Ching Kheng Quah, M. Babu, B. Kalluraya   +3 more
doaj   +1 more source

Correction: Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors [PDF]

, 2016
Correction for 'Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors' by S. Teracciano et al., Chem.
A. Foglia, A. Vassallo, C. Saturnino, G. Bifulco, I. Bruno, M. C. Vaccaro, M. G. Chini, M. Strocchia, R. Riccio, S. Terracciano   +9 more
core   +1 more source

Ethyl 6-methyl-3-(2-methylprop-1-enyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2011
In the molecule of the title compound, C18H22N2O3, the dihydropyrimidinone ring adopts an envelope conformation. The dihedral angle between the phenyl ring and the mean plane through the enamine fragment is 86.04 (7)°.
Xi-Cun Wang, Xue-Hong Tang, Yu-Xia Da, Zhang Zhang, Zheng-Jun Quan   +4 more
doaj   +1 more source