Results 51 to 60 of about 611 (196)

One pot synthesis of thiazolo[2,3-b]dihydropyrimidinone possessing pyrazole moiety and evaluation of their antiinflammatory and antimicrobial activities [PDF]

, 2018
A series of pyrazole integrated thiazolo[2,3-b]dihydropyrimidinone derivatives were synthesized as dual anti-inflammatory and antimicrobial agents. Among the compounds studied, 3-fluoro-4-methylphenyl analogues (3a, 3e, and 3i) are considered to be ...
Shama, P., Shama, Prasanna, Dinesha, Viveka, S., Nagaraja, G. K., Basavarajaswamy, Guru, Rao, K. P., Sreenivasa, M. Y., Rao, K. Poornachandra   +8 more
core   +1 more source

Ethyl 4-[3,5-bis(trifluoromethyl)phenyl]-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
In the title compound, C16H14F6N2O3, the dihydropyrimidinone ring adopts an envelope conformation. In the crystal, molecules are linked by N—H...O and C—H...O hydrogen bonds into a ribbon-like structure along the b axis. In the ribbon,
Hoong-Kun Fun, Ching Kheng Quah, M. Babu, B. Kalluraya   +3 more
doaj   +1 more source

Ethyl 6-methyl-3-(2-methylprop-1-enyl)-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2011
In the molecule of the title compound, C18H22N2O3, the dihydropyrimidinone ring adopts an envelope conformation. The dihedral angle between the phenyl ring and the mean plane through the enamine fragment is 86.04 (7)°.
Xi-Cun Wang, Xue-Hong Tang, Yu-Xia Da, Zhang Zhang, Zheng-Jun Quan   +4 more
doaj   +1 more source

Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review

European Journal of Medicinal Chemistry, 2017
Dihydropyrimidines are the most important heterocyclic ring systems which play an important role in the synthesis of DNA and RNA. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction and Hantzschdihydropyridine.
Kaur, Ramandeep, Chaudhary, Sandeep, Kumar, Kapil, Gupta, Manish K., Rawal, Ravindra K.   +4 more
openaire   +2 more sources

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation [PDF]

, 2018
WOS:000441856300062International audienceBy combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method.
Hassan B. Lazrek, Snoeck, Robert, Lazrek, Hassan B., Robert Snoeck, Vanelle, Patrice, Rodriguez-Ubis, Juan C., Christophe Curti, Moha Taourirte, Juan C. Rodriguez-Ubis, Andrei, Graciela, Kabri, Youssef, Youssef Kabri, Kaoukabi, Hanane, Patrice Vanelle, Curti, Christophe, Taourirte, Moha, Hanane Kaoukabi, Graciela Andrei   +17 more
core   +1 more source

Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one [PDF]

Journal of Pure and Applied Chemistry Research, 2015
Indonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important ...
Masruri MASRURI, Yuga Adi Pranata
doaj  

An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones

E-Journal of Chemistry, 2008
The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)2, as a recycling catalyst, from a diversity of aromatic aldehydes, β ...
Taoues Boumoud, Boudjemaa Boumoud, Salah Rhouati, Ali Belfaitah, Abdelmadjid Debache, Paul Mosset   +5 more
doaj   +1 more source

Ethyl 4-(2,4-difluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
In the title compound, C14H14F2N2O3, the dihydropyrimidinone ring adopts a flattened boat conformation. The difluorophenyl group is disordered over two orientations with occupancies of 0.544 (3) and 0.456 (3).
Hoong-Kun Fun, Chin Sing Yeap, M. Babu, B. Kalluraya   +3 more
doaj   +1 more source

Synthesis and antileishmanial effect of a few cyclic and non-cyclic n-aryl enamino amide derivatives

Research in Pharmaceutical Sciences, 2020
Background and purpose: The prevalence of leishmaniasis is reported in more than 98 countries and Iran is one of the endemic areas. There is no vaccine for this disease and few effective drugs are available to treat it.
Behnam Mohammadi-ghalehbin, Sima Najafi, Nima Razzaghi-Asl   +2 more
doaj   +1 more source