Results 51 to 60 of about 680 (195)

Ethyl 4-(4-cyanophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
The asymmetric unit of the title compound, C15H15N3O2S, contains two independent molecules corresponding to the R and S enantiomers. The dihydropyrimidinone rings adopt a flattened boat conformation.
De-Hong Wu, You-Hong Zhang, Zhu-Feng Li
doaj   +1 more source

Synthesis and antileishmanial effect of a few cyclic and non-cyclic n-aryl enamino amide derivatives

Research in Pharmaceutical Sciences, 2020
Background and purpose: The prevalence of leishmaniasis is reported in more than 98 countries and Iran is one of the endemic areas. There is no vaccine for this disease and few effective drugs are available to treat it.
Behnam Mohammadi-ghalehbin, Sima Najafi, Nima Razzaghi-Asl   +2 more
doaj   +1 more source

A Review on Medicinal Chemistry and Biological Activity of Dihydropyrimidinones Against HIV

Archiv der Pharmazie, Volume 359, Issue 4, April 2026.
This article presents the latest advances in the development of dihydropyrimidinone (DHPM) derivatives as promising candidates against HIV. By exploring their interactions with essential viral targets and highlighting innovative compounds with potent antiviral activity, we provide an updated perspective on the opportunities for new antiretroviral ...
Debora I. Leite, Fernando B. Macedo, Murilo Marinho de C. Lima, Isabelle S. Brum, Jonathan Fragoso Miranda de Oliveira, Ana Clara S. Costa, Stella C. Duarte, Sarah Moon, Stefany de Castro B. Moura, Andressa P. de Oliveira, Nubia Boechat, Monica M. Bastos   +11 more
wiley   +1 more source

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Ethyl 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
In the title compound, C18H19ClN4O3, the dihydropyrimidinone ring adopts a flattened boat conformation. The dihedral angle between the phenyl and pyrazole rings is 43.39 (6)°.
Hoong-Kun Fun, Chin Sing Yeap, K. V. Sujith, B. Kalluraya   +3 more
doaj   +1 more source

Novel azo pyridone dyes based on dihydropyrimidinone skeleton: Synthesis, DFT study and anticancer activity

, 2021
Seven novel azo dyes with 2-pyridone and dihydropyrimidinone moieties have been synthesized and thoroughly characterized. The azo-hydrazone tautomerism has been investigated by experimental and theoretical approaches.
Vitnik, Zeljko J., Matić, Ivana Z., Stanojković, Tatjana, Vitnik, Vesna D., Tadić, Julijana D., Mijin, Dušan, Vitnik, Vesna, Mijin, Dušan Ž., Vitnik, Željko, Tadić, Julijana, Lađarević, Jelena M., Lađarević, Jelena, Stanojkovic, Tatjana P.   +12 more
core   +1 more source

Synthesis of diverse dihydropyrimidine-related scaffolds by fluorous benzaldehyde-based Biginelli reaction and post-condensation modifications

Beilstein Journal of Organic Chemistry, 2011
Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl ...
Bruno Piqani, Wei Zhang
doaj   +1 more source

Synthesis and Characterization of Some New Bis-(Dihydropyrimidinones-5-Carboxamide) by Using Ultrasonic Irradiation [PDF]

Eurasian Journal of Science and Engineering, 2018
This investigation involves synthesis of two new series of bis-dihydropyrimidinone-5-carboxamides (4 a-k) and (5 a-k) from reaction of 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetra-hydropyrimidine-5-carbonyl chloride and its derivatives (3 a, b) with different ...
Faiq H.S.Hussain , Havall O. Abdulla
doaj   +1 more source

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane

Drug Design, Development and Therapy, 2019
Mashooq Ahmad Bhat,1 Mohamed A Al-Omar,1 Azmat Ali Khan,1 Amer M Alanazi,1 Ahmed M Naglah2,31Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutical Chemistry, Drug ...
Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM   +4 more
doaj  

Antidiabetic Evaluation of New Pyrimidine‐Thiazoline Hybrids Endorsed With Enzyme Kinetic Studies and Computational Analysis

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
We demonstrated the application of molecular hybridization in disclosing new pyrimidine‐thiazole molecular hybrids as potential α‐glucosidase and α‐amylase inhibitors and antioxidant agents. The representative compound of the series exhibited 3‐fold more potency than the standard drug acarbose against α‐glucosidase and 2‐fold greater potency than ...
Gobind Kumar, Pule Seboletswe, Neha Manhas, Safiyah Ghumran, Nontobeko Gcabashe, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +8 more
wiley   +1 more source