Results 51 to 60 of about 392 (169)

Synthesis and Characterization of Some New Bis-(Dihydropyrimidinones-5-Carboxamide) by Using Ultrasonic Irradiation [PDF]

Eurasian Journal of Science and Engineering, 2018
This investigation involves synthesis of two new series of bis-dihydropyrimidinone-5-carboxamides (4 a-k) and (5 a-k) from reaction of 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetra-hydropyrimidine-5-carbonyl chloride and its derivatives (3 a, b) with different ...
Faiq H.S.Hussain , Havall O. Abdulla
doaj   +1 more source

Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review

European Journal of Medicinal Chemistry, 2017
Dihydropyrimidines are the most important heterocyclic ring systems which play an important role in the synthesis of DNA and RNA. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction and Hantzschdihydropyridine.
Kaur, Ramandeep, Chaudhary, Sandeep, Kumar, Kapil, Gupta, Manish K., Rawal, Ravindra K.   +4 more
openaire   +2 more sources

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, Volume 20, Issue 11, June 2, 2025.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

Synthesis and antihepatotoxic activity of dihydropyrimidinone derivatives linked with 1,4-benzodioxane

Drug Design, Development and Therapy, 2019
Mashooq Ahmad Bhat,1 Mohamed A Al-Omar,1 Azmat Ali Khan,1 Amer M Alanazi,1 Ahmed M Naglah2,31Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 2Department of Pharmaceutical Chemistry, Drug ...
Bhat MA, Al-Omar MA, Khan AA, Alanazi AM, Naglah AM   +4 more
doaj  

A One-pot Multi-component Synthesis of some New Dihydropyrimidine Derivatives via Biginelli Condensations

Zanco Journal of Pure and Applied Sciences, 2023
The Biginelli Reaction is a one-pot acid catalyzed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalized 3,4-dihydro-2(H)-pyrimidinones (DHPMs).
Rostam R. Braiem
doaj   +1 more source

Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
1‐(2,4‐Dihydroxyphenyl)ethanone functions as a fundamental precursor in the synthesis of dihydropyrimidinone conjugates that incorporate both chromone and triazole moieties. Docking analyses are performed on 15 synthetic compounds. In silico investigations confirm high binding affinity, with docking energies of −10.7 kcal/mol for compound 5a and −10.9 ...
Kumara Swamy Taviti, T. B. Patrudu, Vishnuvardhana Kishore Polisetti, Venkatesh Bhumireddy Chinnachennaiahgari, Satyanarayana Yatam, Naresh Kumar Katari, Rambabu Gundla   +6 more
wiley   +1 more source

Design, Synthesis, Photophysical, Theoretical, and Electrochemical Characterization of Novel Organochalcogen‐DHPM‐Triazole Hybrids

ChemistrySelect, Volume 10, Issue 22, June 11, 2025.
A library of novel organochalcogen‐DHPM‐triazole hybrids was developed using a rapid, simple, and ultrasound‐assisted method. Additionally, all compounds underwent comprehensive theoretical, photophysical, and electrochemical characterization, providing relevant insights for future biological applications.
Amanda R. Azevedo, Patrick C. Nobre, Mateus H. Köhler, Bernardo A. Iglesias, Vanessa Nascimento   +4 more
wiley   +1 more source

STARCH SULFURIC ACID: AN ALTERNATIVE, ECO-FRIENDLY CATALYST FOR BIGINELLI REACTION [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2013
The one-pot multicomponent synthesis of 3,4-dihydropyrimidinone derivatives using starch sulfuric acid as an environmentally friendly biopolymer-based solid acid catalyst from aldehydes, β-keto esters and urea/ thiourea without solvent is described ...
Ramin Rezaei, Sara Malek, Mohammad Reza Sheikhi, Mohammad Kazem Mohammadi   +3 more
doaj  

Fe+3-montmorillonite K10: As an effective and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and –thiones

Bulletin of the Chemical Society of Ethiopia, 2017
In this study, a novel, clean, convenient, appropriate and environmentally benign route to dihydropyrimidinone and thione derivatives has been developed using the reaction between various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the ...
L. Z. Fekri, M. Nikpassand, M. Movaghari
doaj   +1 more source

The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
Heat‐shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the critical challenges posed by its aggressive nature and therapeutic resistance. HSP70’s dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target ...
Amrita Arup Roy, Abhijeet Pandey, Namdev Dhas, Manasa Manjunath Hegde, Harendra S. Parekh, Sai Balaji Andugulapati, Krishnadas Nandakumar, Bola Sadashiva Satish Rao, Srinivas Mutalik, Farshad Mirzavi   +9 more
wiley   +1 more source