Results 71 to 80 of about 611 (196)

Design, Synthesis, Photophysical, Theoretical, and Electrochemical Characterization of Novel Organochalcogen‐DHPM‐Triazole Hybrids

ChemistrySelect, Volume 10, Issue 22, June 11, 2025.
A library of novel organochalcogen‐DHPM‐triazole hybrids was developed using a rapid, simple, and ultrasound‐assisted method. Additionally, all compounds underwent comprehensive theoretical, photophysical, and electrochemical characterization, providing relevant insights for future biological applications.
Amanda R. Azevedo, Patrick C. Nobre, Mateus H. Köhler, Bernardo A. Iglesias, Vanessa Nascimento   +4 more
wiley   +1 more source

Combinatorial Synthesis of 2-Thioxo-4-dihydropyrimidinones [PDF]

, 2016
Combinatorial Synthesis of 2-Thioxo-4 ...
Cheng Leng Lee (3030528), Mui Mui Sim (3030531), Arasu Ganesan (3040221)   +2 more
core   +1 more source

A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability. [PDF]

, 2012
International audienceFollowing the previous SAR of a novel dihydropyrimidinone scaffold as HIV-1 replication inhibitors a detailed study directed towards optimizing the metabolic stability of the ester functional group in the dihydropyrimidinone (DHPM ...
Seo, Minjung, Ahn, Jiye, Liuzzi, Michel, So, Wonyoung, Ko, Yoonae, Jo, Suyeon, Yoon, Jaewan, Kim, Tae-Hee, Choi, Inhee, Kim, Junghwan, Kim, Youngmi, Jo, Mina, No, Zaesung, Ok, Taedong, Park, Youngsam, Park, Changmin, Lee, Doohyun, Han, Sung-Jun, Nam, Jiyoun, Cechetto, Jonathan, Sommer, Peter, Kim, Junwon, Ju, Moon Kyeong   +22 more
core   +1 more source

The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
Heat‐shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the critical challenges posed by its aggressive nature and therapeutic resistance. HSP70’s dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target ...
Amrita Arup Roy, Abhijeet Pandey, Namdev Dhas, Manasa Manjunath Hegde, Harendra S. Parekh, Sai Balaji Andugulapati, Krishnadas Nandakumar, Bola Sadashiva Satish Rao, Srinivas Mutalik, Farshad Mirzavi   +9 more
wiley   +1 more source

Fe+3-montmorillonite K10: As an effective and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and –thiones

Bulletin of the Chemical Society of Ethiopia, 2017
In this study, a novel, clean, convenient, appropriate and environmentally benign route to dihydropyrimidinone and thione derivatives has been developed using the reaction between various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the ...
L. Z. Fekri, M. Nikpassand, M. Movaghari
doaj   +1 more source

Human transforming growth factor β type I receptor in complex with kinase inhibitor SB505124

Acta Crystallographica Section F, Volume 80, Issue 11, Page 314-319, November 2024.
This study presents the crystal structure of transforming growth factor β type I receptor (TβR1) in complex with SB505124, highlighting the specific contacts that SB505124 makes with TβR1 and comparing these interactions with those of SB431542.The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in ...
Jhon A. Rodriguez Buitrago, Maréne Landström, Magnus Wolf-Watz   +2 more
wiley   +1 more source

Design, synthesis, and characterization of (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis

Drug Design, Development and Therapy, 2016
Katharigatta N Venugopala,1,2 G B Dharma Rao,3 Subhrajyoti Bhandary,3 Melendhran Pillay,4 Deepak Chopra,3 Bandar E Aldhubiab,1 Mahesh Attimarad,1 Osama Ibrahim Alwassil,1 Sree Harsha,1 Koleka Mlisana4 1Department of Pharmaceutical Sciences, College of ...
Venugopala KN, Dharma Rao GB, Bhandary S, Pillay M, Chopra D, Aldhubiab BE, Attimarad M, Alwassil OI, Harsha S, Mlisana K   +9 more
doaj  

Naphthyl‐Based Chalcone Derivatives: A Multifaceted Player in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 19, May 21, 2024.
This review insights the pharmacological activity of naphthyl substituted chalcone derivatives. The anticancer and antibacterial activities were more explored than other activities. The presence of methoxy and naphthyl moiety enhanced the anticancer activity. The antibacterial activity was increased by electron withdrawing groups.
Priyanka Mahesha, Nitinkumar S. Shetty
wiley   +1 more source

Synthesis And Bioactivity of Dihydropyrimidinone (DHPM) Derivatives

European Chemical Bulletin
Dihydropyrimidinones (DHPMs) is an main type of heterocyclic compounds whih shows biological activities. This review/article focuses on the synthetic strategies employed for the construction of DHPM frameworks and highlights their bioactivity profiles across various pharmacological targets.
Ganesh L. Kirdat, Onkar S. Dhindale, Tushar M. Dalimbkar, Mr. Nikhil A. Mandlik   +3 more
openaire   +2 more sources

Update on chiral recognition mechanisms in separation science

Journal of Separation Science, Volume 47, Issue 9-10, May 2024.
The stereospecific analysis of chiral molecules is an important issue in many scientific fields. In separation sciences, this is achieved via the formation of transient diastereomeric complexes between a chiral selector and the selectand enantiomers driven by molecular interactions including electrostatic, ion‐dipole, dipole‐dipole, van der Waals or π ...
Gerhard K. E. Scriba
wiley   +1 more source