Results 71 to 80 of about 680 (195)

The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
Heat‐shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the critical challenges posed by its aggressive nature and therapeutic resistance. HSP70’s dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target ...
Amrita Arup Roy, Abhijeet Pandey, Namdev Dhas, Manasa Manjunath Hegde, Harendra S. Parekh, Sai Balaji Andugulapati, Krishnadas Nandakumar, Bola Sadashiva Satish Rao, Srinivas Mutalik, Farshad Mirzavi   +9 more
wiley   +1 more source

Design, synthesis, and characterization of (1-(4-aryl)-1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis

Drug Design, Development and Therapy, 2016
Katharigatta N Venugopala,1,2 G B Dharma Rao,3 Subhrajyoti Bhandary,3 Melendhran Pillay,4 Deepak Chopra,3 Bandar E Aldhubiab,1 Mahesh Attimarad,1 Osama Ibrahim Alwassil,1 Sree Harsha,1 Koleka Mlisana4 1Department of Pharmaceutical Sciences, College of ...
Venugopala KN, Dharma Rao GB, Bhandary S, Pillay M, Chopra D, Aldhubiab BE, Attimarad M, Alwassil OI, Harsha S, Mlisana K   +9 more
doaj  

Human transforming growth factor β type I receptor in complex with kinase inhibitor SB505124

Acta Crystallographica Section F, Volume 80, Issue 11, Page 314-319, November 2024.
This study presents the crystal structure of transforming growth factor β type I receptor (TβR1) in complex with SB505124, highlighting the specific contacts that SB505124 makes with TβR1 and comparing these interactions with those of SB431542.The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in ...
Jhon A. Rodriguez Buitrago, Maréne Landström, Magnus Wolf-Watz   +2 more
wiley   +1 more source

Naphthyl‐Based Chalcone Derivatives: A Multifaceted Player in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 19, May 21, 2024.
This review insights the pharmacological activity of naphthyl substituted chalcone derivatives. The anticancer and antibacterial activities were more explored than other activities. The presence of methoxy and naphthyl moiety enhanced the anticancer activity. The antibacterial activity was increased by electron withdrawing groups.
Priyanka Mahesha, Nitinkumar S. Shetty
wiley   +1 more source

Synthesis of some dihydropyrimidinone derivatives and study of their anti-inflammatory activity

Journal of Applied Pharmaceutical Research, 2018
This research revealed that the numbers of available heterocyclic compounds are mainly focused on nitrogen containing compounds, such as quinazolines, indoles, benzimidazole, quinoxalines, coumarins and pyrimidines etc. A mixture of substituted aldehydes
Naresh Podilla, Tirthankar Choudhury
doaj   +1 more source

Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation

, 2018
WOS:000441856300062International audienceBy combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method.
Hassan B. Lazrek, Snoeck, Robert, Lazrek, Hassan B., Robert Snoeck, Vanelle, Patrice, Rodriguez-Ubis, Juan C., Christophe Curti, Moha Taourirte, Juan C. Rodriguez-Ubis, Andrei, Graciela, Kabri, Youssef, Youssef Kabri, Kaoukabi, Hanane, Patrice Vanelle, Curti, Christophe, Taourirte, Moha, Hanane Kaoukabi, Graciela Andrei   +17 more
core   +1 more source

Microwave-assisted synthesis of -CF3 functionalized 3,4-dihydropyrimidinone/thione/imine derivatives by using potassium phthalimide (PPI) as a green and reusable organocatalyst and their anti-microbial evaluation

, 2023
600-617One-pot synthesis of novel -CF3 functional group containing 3,4-dihydropyrimidinone/thione/imine derivatives 8a-l, 9a-l and 10a-l has been successfully performed in high yields through the reaction of aromatic aldehydes, β-dicarbonyl compound ...
Odiya, Suresh P, Das, Siva Prasad, Boruah, Jeena Jyoti   +2 more
core   +1 more source

Update on chiral recognition mechanisms in separation science

Journal of Separation Science, Volume 47, Issue 9-10, May 2024.
The stereospecific analysis of chiral molecules is an important issue in many scientific fields. In separation sciences, this is achieved via the formation of transient diastereomeric complexes between a chiral selector and the selectand enantiomers driven by molecular interactions including electrostatic, ion‐dipole, dipole‐dipole, van der Waals or π ...
Gerhard K. E. Scriba
wiley   +1 more source

Eg5 and Diseases: From the Well‐Known Role in Cancer to the Less‐Known Activity in Noncancerous Pathological Conditions

Biochemistry Research International, Volume 2024, Issue 1, 2024.
Eg5 is a protein encoded by KIF11 gene and is primarily involved in correct mitotic cell division. It is also involved in nonmitotic processes such as polypeptide synthesis, protein transport, and angiogenesis. The scientific literature sheds light on the ubiquitous functions of KIF11 and its involvement in the onset and progression of different ...
Alessia Ricci, Simone Carradori, Amelia Cataldi, Susi Zara, Anup Pathania   +4 more
wiley   +1 more source

(6aS*,6bS*,11R*,11aR*)-6-(2-Furylmethyl)-5,12-dioxo-5,6,6a,6b,7,11,11a,12-octahydrofuro[3′,2′:5,6]isoindolo[2,1-a]quinazoline-11-carboxylic acid

Acta Crystallographica Section E, 2011
The title compound, C23H18N2O6, is the product of an intramolecular thermal cycloaddition within 1-malein-2-[(E)-2-(2-furyl)vinyl]-4-oxo-3,4-dihydroquinazoline.
Mykola D. Obushak, Yuri I. Horak, Vladimir P. Zaytsev, Ekaterina L. Motorygina, Fedor I. Zubkov, Victor N. Khrustalev   +5 more
doaj   +1 more source