Results 91 to 100 of about 680 (195)

A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability.

, 2012
International audienceFollowing the previous SAR of a novel dihydropyrimidinone scaffold as HIV-1 replication inhibitors a detailed study directed towards optimizing the metabolic stability of the ester functional group in the dihydropyrimidinone (DHPM ...
Seo, Minjung, Ahn, Jiye, Liuzzi, Michel, So, Wonyoung, Ko, Yoonae, Jo, Suyeon, Yoon, Jaewan, Kim, Tae-Hee, Choi, Inhee, Kim, Junghwan, Kim, Youngmi, Jo, Mina, No, Zaesung, Ok, Taedong, Park, Youngsam, Park, Changmin, Lee, Doohyun, Han, Sung-Jun, Nam, Jiyoun, Cechetto, Jonathan, Sommer, Peter, Kim, Junwon, Ju, Moon Kyeong   +22 more
core   +1 more source

Characterization of a Thermally Induced Irreversible Conformational Transition of Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase in Enantioseparation of Dihydropyrimidinone Acid by Quasi-Equilibrated Liquid Chromatography and Solid-State NMR

, 2016
A thermally induced irreversible conformational transition of amylose tris(3,5-dimethylphenylcarbamate) (i.e., Chiralpak AD) chiral stationary phase (CSP) in the enantioseparation of dihydropyrimidinone (DHP) acid racemate was studied for the first time ...
Robert M. Wenslow, (2943429), Fang Wang (105926), Thomas M. Dowling (2943426), Ivan Santos (2649235), Jean M. Wyvratt (2943423), Karl T. Mueller (1487707)   +5 more
core   +1 more source

DIHYDROPYRIMIDINONE DERIVED CHALCONES AS EMERGING ANTICANCER SCAFFOLDS AGAINST A549 LUNG CANCER CELL LINES

Novel dihydropyrimidnone chalcones were synthesized by using Clasein Schmidth condensation from 5-acetyl, 6-methyl, 4- (3- ethoxy, 4-hydroxy phenyl) dihyro pyrimidine-2-one by reacting with various substituted aldehydes.
Prasanth Yarramsetti, Motupalli Sri Sai Supratheeka, Jagadeeswara Rao Batna, Nuziveeti Lakshmi Durga Bhavani, Nukala Lalitha Naga Valli Sri Chandrika, Kiran Manda, Dharmasoth Rama Devi, Suknkari Vasanthi   +7 more
core   +1 more source

Sustainable Biginelli chemistry: Indian contributions to green multicomponent synthesis

Discover Chemistry
The Biginelli Reaction is a one-pot acid-catalysed cyclo-condensation procedure that combines urea, β-ketoester, and aromatic aldehydes to create functionalised DHPMs. For more than a century, this three-component reaction has been recognised as a method
Rajni, Sahil, Neera Raghav, Anjaneyulu Bendi, G. B. Dharma Rao   +4 more
doaj   +1 more source

Exploring the binding dynamics of anticancer Dihydropyrimidinone derivatives with Serum Albumin: A multispectral approach

Chemical Physics Impact
In this work, we have investigated the synthesis and characterization of two novel anticancer agents, 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (L1) and 2-Acetyl-4-(3,4-dimethoxy-phenyl)-6-methyl-3,4-dihydro-1H-pyrimidin-2-one (L2 ...
Chandraprakash Gond, Shivani Daksh, Akanksha Mishra, Nikhil Kumar, Anupama Datta, Anjani Kumar Tiwari   +5 more
doaj   +1 more source

Epidemiological studies of multiresistant bacteria in the city of Pelotas and susceptibility to dihydropyrimidinone

, 2019
Bacterial resistance to antibiotics is a global public health problem. The indiscriminate use of antibiotics has accelerated this process, causing increased morbidity and mortality of healthcare-related infections. The increasing inefficiency of existing
Jara, Marisa Castro
core   +2 more sources

Green and Efficient Synthesis of Dihydropyrimidinone Analogues via Hpa-Clay Catalyzed Biginelli Reaction

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry
This study introduces an environmentally sustainable approach for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs), via the Biginelli reaction. A heterogeneous catalyst, Heteropolyacid-Clay (HPA-Clay), is developed by immobilizing H5PV2W10O40 on ...
Nuzhat Rehman, Ayaz Mahmood Dar, Raja Feroz Ahmad Haji, Sharief-ud-din Khan, Deepak Pareek, Saleem Farooq, Bashir Ahmad Dar   +6 more
doaj   +1 more source

Copper salt of a DABCO-based molten salt: a high-performance catalyst in the one-pot synthesis of 3,4-dihydropyrimidine and polyhydroquinoline derivatives. [PDF]

RSC Adv, 2023
Fekrat N, Mazloumi M, Shirini F.
europepmc   +1 more source

Design, synthesis, and antiproliferative evaluation of dihydropyrimidinone-pyrazole derivatives as potential SHP2 inhibitors via in silico target prediction

AIM: To design and synthesize novel dihydropyrimidinone-pyrazole hybrid compounds as potent and selective antitumor agents, exploring their potential mechanism of action.
Kou, Shibo, Yi, Hong, Li, Siqi, Peng, Xiaojiong, Sun, Lianqi, Li, Zhuorong   +5 more
core   +1 more source

Bioactivity of dihydropyrimidinone derivatives as inhibitors of cyclooxygenase-2 (COX-2): an in silico approach. [PDF]

RSC Adv, 2023
Haq KU, Sa'adah NL, Siswanto I, Suwito H.   +3 more
europepmc   +1 more source