Results 111 to 120 of about 1,000 (202)

Exploring the binding dynamics of anticancer Dihydropyrimidinone derivatives with Serum Albumin: A multispectral approach

Chemical Physics Impact
In this work, we have investigated the synthesis and characterization of two novel anticancer agents, 5-acetyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one (L1) and 2-Acetyl-4-(3,4-dimethoxy-phenyl)-6-methyl-3,4-dihydro-1H-pyrimidin-2-one (L2 ...
Chandraprakash Gond, Shivani Daksh, Akanksha Mishra, Nikhil Kumar, Anupama Datta, Anjani Kumar Tiwari   +5 more
doaj   +1 more source

Sustainable Biginelli chemistry: Indian contributions to green multicomponent synthesis

Discover Chemistry
The Biginelli Reaction is a one-pot acid-catalysed cyclo-condensation procedure that combines urea, β-ketoester, and aromatic aldehydes to create functionalised DHPMs. For more than a century, this three-component reaction has been recognised as a method
Rajni, Sahil, Neera Raghav, Anjaneyulu Bendi, G. B. Dharma Rao   +4 more
doaj   +1 more source

Benchtop ¹⁹F Nuclear Magnetic Resonance (NMR) Spectroscopy Provides Mechanistic Insight into the Biginelli Condensation toward the Chemical Synthesis of Novel Trifluorinated Dihydro- and Tetrahydropyrimidinones as Antiproliferative Agents. [PDF]

ACS Omega, 2023
Chen R, Singh P, Su S, Kocalar S, Wang X, Mandava N, Venkatesan S, Ferguson A, Rao A, Le E, Rojas C, Njoo E.   +11 more
europepmc   +1 more source

PRACTICAL APPROACH TO GREEN CHEMISTRY [PDF]

, 2017
Objective: The basic principles of green chemistry addresses various issues related to synthesis of chemical compounds: planning organic synthesis to maximise yield, prevention/minimization of waste, atom economy, the use of less lethal chemicals, use of
Bhandari, Meena, Raj, Seema
core   +1 more source

Studies on some Bio-active Organic Compounds [PDF]

, 2009
Not ...
Bhalodia, Rahulkumar H.
core  

Synthesis, cytotoxic effect and cell cycle analysis of novel cyclic and acyclic N-heteroaryl enamino amides on AGS, Hep-G2 and MCF-7 human cancer cell lines [PDF]

Cancer is a generic term used for a group of diseases being characterized by growth, proliferation and spread of abnormal cells. Globally, cancer is the second cause of death after cardiovascular diseases.
بهلولی, شهاب, رزاقی اصل, نیما, سپهری, ساقی, نجاتخواه, نگین   +3 more
core  

Hybrid Dihydropyrimidinones Targeting AKT Signaling: Antitumor Activity in Hormone-Dependent 2D and 3D Cancer Models. [PDF]

Pharmaceutics
Tejada AH, Santos SJ, Lobo GT, Ariwoola AA, Bezerra AJA, Stringhetta GR, Gomes INF, da Silva LS, Reis RMV, Preto DD, Russowsky D, Silva-Oliveira RJ.   +11 more
europepmc   +1 more source

Corrigendum to "Synthesis, characterization and biological profile of some new dihydropyrimidinone derivaties" [Heliyon Volume 11, Issue 1, 15 January 2025, e41152]. [PDF]

Heliyon
Kanwal M, Nadeem H, Malik S, Maqsood S.
europepmc   +1 more source

Design, synthesis and evaluation of fluorescent dihydropyridine-dihydropyrimidinone hybrids as inducers of cell-cycle arrest in a prostate cancer cell line <i>via</i> Aurora kinase interactions. [PDF]

RSC Med Chem
de Souza VP, Gomes INF, Santos SJ, Braga CB, Bezerra AJA, Philot EA, Ramos CRN, Pantaleão SQ, da Silva LS, Pilli RA, Reis RM, Oliveira RJS, Russowsky D.   +12 more
europepmc   +1 more source

An updated review of fatty acid residue-tethered heterocyclic compounds: synthetic strategies and biological significance. [PDF]

RSC Adv, 2023
Majrashi TA, Sabt A, Abd El Salam HA, Al-Ansary GH, Hamissa MF, Eldehna WM.   +5 more
europepmc   +1 more source