Results 61 to 70 of about 611 (196)
Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.We demonstrated the application of molecular hybridization in disclosing new pyrimidine‐thiazole molecular hybrids as potential α‐glucosidase and α‐amylase inhibitors and antioxidant agents. The representative compound of the series exhibited 3‐fold more potency than the standard drug acarbose against α‐glucosidase and 2‐fold greater potency than ...
Gobind Kumar +8 more
wiley +1 more source
Ethyl 4-(4-cyanophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
Acta Crystallographica Section E, 2009 The asymmetric unit of the title compound, C15H15N3O2S, contains two independent molecules corresponding to the R and S enantiomers. The dihydropyrimidinone rings adopt a flattened boat conformation.
De-Hong Wu, You-Hong Zhang, Zhu-Feng Li
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ChemistrySelect, Volume 10, Issue 38, October 13, 2025.Thioxolone derivatives are evaluated for antibacterial and anti‐diabetic potential. Compounds T‐11, T‐12, and T‐13 exhibit potent antibacterial activity against E. coli, B. cereus, and S. aureus, with low MIC values. T‐11 and T‐3 show stronger α‐glucosidase inhibition than acarbose, while molecular docking reveals T‐13 as the strongest binder ...
Thohidjhon Khajavali SK +3 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2011 Dihydropyrimidinones and dihydropyrimidinethiones generated from the Biginelli reactions of perfluorooctanesulfonyl-attached benzaldehydes are used as common intermediates for post-condensation modifications such as cycloaddition, Liebeskind–Srogl ...
Bruno Piqani, Wei Zhang
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Acta Crystallographica Section E, 2009 In the title compound, C18H19ClN4O3, the dihydropyrimidinone ring adopts a flattened boat conformation. The dihedral angle between the phenyl and pyrazole rings is 43.39 (6)°.
Hoong-Kun Fun +3 more
doaj +1 more source
Synthesis and Characterization of Some New Bis-(Dihydropyrimidinones-5-Carboxamide) by Using Ultrasonic Irradiation [PDF]
Eurasian Journal of Science and Engineering, 2018 This investigation involves synthesis of two new series of bis-dihydropyrimidinone-5-carboxamides (4 a-k) and (5 a-k) from reaction of 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetra-hydropyrimidine-5-carbonyl chloride and its derivatives (3 a, b) with different ...
Faiq H.S.Hussain , Havall O. Abdulla
doaj +1 more source
Aromatization of differently substituted 3,4-dihydropyrimidinone derivatives [PDF]
, 2016 Biginellijevom reakcijom, pripravljeni su razliĉito supstituirani derivati 3,4-dihidropirimidinona. Koristeći modelni derivat 124-I-b provedena su opsežna preliminarna ispitivanja u svrhu pronalaska odgovarajućih uvjeta aromatizacije sintetiziranih ...
Lesjak Kolarović, Danijela
core
Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors
ChemistrySelect, Volume 10, Issue 21, June 4, 2025.1‐(2,4‐Dihydroxyphenyl)ethanone functions as a fundamental precursor in the synthesis of dihydropyrimidinone conjugates that incorporate both chromone and triazole moieties. Docking analyses are performed on 15 synthetic compounds. In silico investigations confirm high binding affinity, with docking energies of −10.7 kcal/mol for compound 5a and −10.9 ...
Kumara Swamy Taviti +6 more
wiley +1 more source
Three-Component Biginelli Cyclocondensation Reaction Using C-Glycosylated Substrates. Preparation of a Collection of Dihydropyrimidinone Glycoconjugates and the Synthesis of C-Glycosylated Monastrol Analogues† [PDF]
, 2016 The aldehyde−ketoester−urea cyclocondensation reaction has been revisited using C-glycosylated reagents with the aim of exploring a potential entry to a library of dihydropyrimidinone glycoconjugates.
Alessandro Massi (1528462) +3 more
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Zanco Journal of Pure and Applied Sciences, 2023 The Biginelli Reaction is a one-pot acid catalyzed cyclocondensation of -keto ester, urea and aromatic aldehyde which leads to the synthesis of functionalized 3,4-dihydro-2(H)-pyrimidinones (DHPMs).
Rostam R. Braiem
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