Results 61 to 70 of about 680 (195)

Exploration of Thioxolone Derivatives: Synthesis, Docking Studies, and Biological Evaluation for Antibacterial and Antidiabetic Activities

ChemistrySelect, Volume 10, Issue 38, October 13, 2025.
Thioxolone derivatives are evaluated for antibacterial and anti‐diabetic potential. Compounds T‐11, T‐12, and T‐13 exhibit potent antibacterial activity against E. coli, B. cereus, and S. aureus, with low MIC values. T‐11 and T‐3 show stronger α‐glucosidase inhibition than acarbose, while molecular docking reveals T‐13 as the strongest binder ...
Thohidjhon Khajavali SK, Satya Sree Nannapaneni, Rambabu Gundla, Naresh Kumar Katari   +3 more
wiley   +1 more source

Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review

European Journal of Medicinal Chemistry, 2017
Dihydropyrimidines are the most important heterocyclic ring systems which play an important role in the synthesis of DNA and RNA. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction and Hantzschdihydropyridine.
Kaur, Ramandeep, Chaudhary, Sandeep, Kumar, Kapil, Gupta, Manish K., Rawal, Ravindra K.   +4 more
openaire   +2 more sources

STARCH SULFURIC ACID: AN ALTERNATIVE, ECO-FRIENDLY CATALYST FOR BIGINELLI REACTION [PDF]

Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2013
The one-pot multicomponent synthesis of 3,4-dihydropyrimidinone derivatives using starch sulfuric acid as an environmentally friendly biopolymer-based solid acid catalyst from aldehydes, β-keto esters and urea/ thiourea without solvent is described ...
Ramin Rezaei, Sara Malek, Mohammad Reza Sheikhi, Mohammad Kazem Mohammadi   +3 more
doaj  

Cytotoxic Evaluation, Molecular Docking, and 2D-QSAR Studies of Dihydropyrimidinone Derivatives as Potential Anticancer Agents

, 2022
The diverse pharmacological role of dihydropyrimidinone scaffold has made it to be an interesting drug target. Because of the high incidence and mortality rate of breast cancer, there is a dire need of discovering new pharmacotherapeutic agents in ...
Nadeem, Humaira, Sulaiman, Muhammad, Altaf, Reem, Zafar, Hajra, Paiva-Santos, Ana Cláudia, Raza, Faisal, Ilyas, Umair, Iqbal, Jamshed, Paracha, Rehan Zafar   +8 more
core   +1 more source

Three‐Component Biginelli Cyclocondensation Reaction Using C‐Glycosylated Substrates. Preparation of a Collection of Dihydropyrimidinone Glycoconjugates and the Synthesis of C‐Glycosylated Monastrol Analogues.

, 2002
The aldehyde-ketoester-urea cyclocondensation reaction has been revisited using C-glycosylated reagents with the aim of exploring a potential entry to a library of dihydropyrimidinone glycoconjugates.
Simona Sabbatini, BERTOLASI, Valerio, SABBATINI S, Alessandro Massi, Alessandro Dondoni, MASSI, Alessandro, DONDONI, Alessandro, Valerio Bertolasi   +7 more
core   +2 more sources

Fe+3-montmorillonite K10: As an effective and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and –thiones

Bulletin of the Chemical Society of Ethiopia, 2017
In this study, a novel, clean, convenient, appropriate and environmentally benign route to dihydropyrimidinone and thione derivatives has been developed using the reaction between various benzaldehydes, urea or thiourea, and ethyl acetoacetate in the ...
L. Z. Fekri, M. Nikpassand, M. Movaghari
doaj   +1 more source

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold

, 2015
Hsp90 C-terminal ligands are potential new anti-cancer drugs alternative to the more studied N-terminal inhibitors. Here we report the identification of a new dihydropyrimidinone binding the C-terminus, which is not structurally related to other well ...
Dal Piaz, F., RICCIO, Raffaele, Strocchia, M., Vassallo, Antonio, LEONE, ANTONIETTA, BIFULCO, Giuseppe, Terracciano, S., TERRACCIANO, Stefania, CHINI, MARIA GIOVANNA, BRUNO, Ines, Bruno, I., Vaccaro, M. C., Bifulco, G., Chini, M. G., Leone, A., Vaccaro, Maria C., STROCCHIA, MARIA, DAL PIAZ, FABRIZIO, Riccio, R.   +18 more
core   +1 more source

Dihydropyrimidinone Based Chromones as New α‐Glucosidase Inhibitors

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
1‐(2,4‐Dihydroxyphenyl)ethanone functions as a fundamental precursor in the synthesis of dihydropyrimidinone conjugates that incorporate both chromone and triazole moieties. Docking analyses are performed on 15 synthetic compounds. In silico investigations confirm high binding affinity, with docking energies of −10.7 kcal/mol for compound 5a and −10.9 ...
Kumara Swamy Taviti, T. B. Patrudu, Vishnuvardhana Kishore Polisetti, Venkatesh Bhumireddy Chinnachennaiahgari, Satyanarayana Yatam, Naresh Kumar Katari, Rambabu Gundla   +6 more
wiley   +1 more source

Design, Synthesis, Photophysical, Theoretical, and Electrochemical Characterization of Novel Organochalcogen‐DHPM‐Triazole Hybrids

ChemistrySelect, Volume 10, Issue 22, June 11, 2025.
A library of novel organochalcogen‐DHPM‐triazole hybrids was developed using a rapid, simple, and ultrasound‐assisted method. Additionally, all compounds underwent comprehensive theoretical, photophysical, and electrochemical characterization, providing relevant insights for future biological applications.
Amanda R. Azevedo, Patrick C. Nobre, Mateus H. Köhler, Bernardo A. Iglesias, Vanessa Nascimento   +4 more
wiley   +1 more source

One pot synthesis of thiazolo[2,3-b]dihydropyrimidinone possessing pyrazole moiety and evaluation of their antiinflammatory and antimicrobial activities

, 2018
A series of pyrazole integrated thiazolo[2,3-b]dihydropyrimidinone derivatives were synthesized as dual anti-inflammatory and antimicrobial agents. Among the compounds studied, 3-fluoro-4-methylphenyl analogues (3a, 3e, and 3i) are considered to be ...
Shama, P., Shama, Prasanna, Dinesha, Viveka, S., Nagaraja, G. K., Basavarajaswamy, Guru, Rao, K. P., Sreenivasa, M. Y., Rao, K. Poornachandra   +8 more
core   +1 more source