Results 61 to 70 of about 1,000 (202)

Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review

European Journal of Medicinal Chemistry, 2017
Dihydropyrimidines are the most important heterocyclic ring systems which play an important role in the synthesis of DNA and RNA. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction and Hantzschdihydropyridine.
Kaur, Ramandeep, Chaudhary, Sandeep, Kumar, Kapil, Gupta, Manish K., Rawal, Ravindra K.   +4 more
openaire   +2 more sources

Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one [PDF]

Journal of Pure and Applied Chemistry Research, 2015
Indonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important ...
Masruri MASRURI, Yuga Adi Pranata
doaj  

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Ethyl 4-(4′-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-carboxylate Prevents Progression of Monocrotaline-induced Pulmonary Arterial Hypertension in Rats [PDF]

, 2017
Therapies to prevent onset and progression of pulmonary arterial pressure are not very effective yet. This study was designed to investigate the effects of a novel dihydropyrimidinone, ethyl 4-(4′-heptanoyloxyphenyl)-6-methyl-3,4-dihydropyrimidin-2-one-5-
Deep, Satyanarayan, Kohli, Ekta, Malik, S. M., Prasad, A. K., Prasad, Dipti N, Ranjan, Rahul, Singh, Shashi Bala   +6 more
core   +2 more sources

An Efficient and Recycling Catalyst for the One-Pot Three-Component Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-ones

E-Journal of Chemistry, 2008
The Biginelli one-pot three-component cyclocondensation was applied in this work to prepare 3,4-dihydropyrimidinone and its analogues using the first derivative of lead, Pb(NO3)2, as a recycling catalyst, from a diversity of aromatic aldehydes, β ...
Taoues Boumoud, Boudjemaa Boumoud, Salah Rhouati, Ali Belfaitah, Abdelmadjid Debache, Paul Mosset   +5 more
doaj   +1 more source

Ethyl 4-(2,4-difluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
In the title compound, C14H14F2N2O3, the dihydropyrimidinone ring adopts a flattened boat conformation. The difluorophenyl group is disordered over two orientations with occupancies of 0.544 (3) and 0.456 (3).
Hoong-Kun Fun, Chin Sing Yeap, M. Babu, B. Kalluraya   +3 more
doaj   +1 more source

Synthesis of pyrimidines, aromatic and heteroaromatic acids as Biginelli reaction catalysts [PDF]

, 2015
Aromatic as well as heteroaromatic acids were found to beexcellent catalysts for the Biginelli three component synthesisof dihydropyrimidinones. Benzoic acid, substituted benzoic acids, five- and six- membered heterocyclic acids can be used for this ...
Adnan, Muhammad, Ain Khan, Misbahul, Ain, Quratul, Amina, Humaira, Kanwal, Fareeha, Lin, Whei-Oh, Naeem Khan, Muhammad, Nazeer, Areesha, Perveen, Saima, Uzzaman, Ashar   +9 more
core  

Synthesis and antileishmanial effect of a few cyclic and non-cyclic n-aryl enamino amide derivatives

Research in Pharmaceutical Sciences, 2020
Background and purpose: The prevalence of leishmaniasis is reported in more than 98 countries and Iran is one of the endemic areas. There is no vaccine for this disease and few effective drugs are available to treat it.
Behnam Mohammadi-ghalehbin, Sima Najafi, Nima Razzaghi-Asl   +2 more
doaj   +1 more source

Antidiabetic Evaluation of New Pyrimidine‐Thiazoline Hybrids Endorsed With Enzyme Kinetic Studies and Computational Analysis

Chemical Biology &Drug Design, Volume 106, Issue 6, December 2025.
We demonstrated the application of molecular hybridization in disclosing new pyrimidine‐thiazole molecular hybrids as potential α‐glucosidase and α‐amylase inhibitors and antioxidant agents. The representative compound of the series exhibited 3‐fold more potency than the standard drug acarbose against α‐glucosidase and 2‐fold greater potency than ...
Gobind Kumar, Pule Seboletswe, Neha Manhas, Safiyah Ghumran, Nontobeko Gcabashe, Gaurav Bhargava, Almahi Idris, Md. Shahidul Islam, Parvesh Singh   +8 more
wiley   +1 more source

Ethyl 4-(4-cyanophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Acta Crystallographica Section E, 2009
The asymmetric unit of the title compound, C15H15N3O2S, contains two independent molecules corresponding to the R and S enantiomers. The dihydropyrimidinone rings adopt a flattened boat conformation.
De-Hong Wu, You-Hong Zhang, Zhu-Feng Li
doaj   +1 more source