Results 21 to 30 of about 680 (195)

Specific TLR4 Blocking Effect of a Novel 3,4-Dihydropyrimidinone Derivative

Frontiers in Pharmacology, 2021
Background: Toll-like receptor 4 (TLR4) initiates both innate and adaptive immune responses, which plays an important protective role in self-defense mechanisms.
Mingqian Zhou, Yiqi Wang, Xiaoying Lin, Jieping Wan, Chengping Wen   +4 more
doaj   +1 more source

Dihydropyrimidinones Against Multiresistant Bacteria

Frontiers in Microbiology, 2022
The increase in bacterial resistance to antimicrobials has led to high morbidity and mortality rates, posing a major public health problem, requiring the discovery of novel antimicrobial substances. The biological samples were identified as the Gram-negative bacilli Acinetobacter baumannii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae,
Marisa Castro Jara, Marisa Castro Jara, Allison Carlos Assunção Silva, Marina Ritter, Adriana Fernandes da Silva, Carolina Lambrecht Gonçalves, Pedro Rassier dos Santos, Luciano Sisconetto Borja, Cláudio Martin Pereira de Pereira, Patrícia da Silva Nascente, Patrícia da Silva Nascente   +10 more
openaire   +3 more sources

Oxidative Dehydrogenation of Dihydropyrimidinones and Dihydropyrimidines [PDF]

Organic Letters, 2005
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kana, Yamamoto, Ye Grace, Chen, Frédéric G, Buono   +2 more
openaire   +2 more sources

Rational Design, Synthesis, and Biological Evaluation of New Substituted Dihydropyrimidinones as Antibacterial Agents and β-Lactamase Inhibitors. [PDF]

Chem Biol Drug Des
Novel 1,6‐dihydropyrimidinones act as antibacterial agents and beta‐lactamase inhibitors. Compounds 3d, 3i, and 7b demonstrated enhanced beta‐lactamase inhibition relative to the standard reference, clavulanic acid, demonstrating significant potentiation effects to restore antibiotic efficacy and combat resistant bacterial strains. ABSTRACT A series of
Soliman AM, Allam HA, Mahmoud WR, Naguib BH.   +3 more
europepmc   +2 more sources

One pot three components solvent free synthesis of 4-substituted phenyl-2-(sulfanyl/oxo) pyrimidine-5-carboxylate derivatives

Results in Chemistry, 2022
An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed.
Sourav Handique, Priyanka Sharma
doaj   +1 more source

SbPh₃: An Efficient Catalyst for Dihydropyrimidinone and Dihydropyrimidin-5-carboxamide Synthesis Using the Biginelli Reaction

, 2023
SbPh3: An Efficient Catalyst for Dihydropyrimidinone and Dihydropyrimidin-5-carboxamide Synthesis Using the Biginelli ...
Suman Lata (369115), Santosh Kumari Bajiya (15193603), Shatabdi Basu (15193606), Anamika Khaskel (12240476), Rakesh Kumar Sharma (7271042)   +4 more
core   +1 more source

Aromatization of differently substituted 3,4-dihydropyrimidinone derivatives [PDF]

, 2016
Biginellijevom reakcijom, pripravljeni su razliĉito supstituirani derivati 3,4-dihidropirimidinona. Koristeći modelni derivat 124-I-b provedena su opsežna preliminarna ispitivanja u svrhu pronalaska odgovarajućih uvjeta aromatizacije sintetiziranih ...
Lesjak Kolarović, Danijela
core   +3 more sources

5-Acetyl-4-(2,5-dimethoxyphenyl)-6-methyl-1-(prop-2-ynyl)-3,4-dihydropyrimidin-2(1H)-one

IUCrData, 2017
In the title compound, C18H20N2O4, the 3,4-dihydropyrimidin-2(1H)-one ring has a screw-boat conformation. The mean plane through this heterocycle is almost perpendicular to the prop-2-ynyl chain and to the benzene ring, with which it makes a dihedral ...
Hanane Kaoukabi, Moha Taourirte, Mohamed El Azhari, Hassan B. Lazrek, Mohamed Saadi, Lahcen El Ammari   +5 more
doaj   +1 more source

New Anticancer 4-Aryldihydropyrimidinone-5-Carboxylates Targeting Hsp90. [PDF]

Chem Biol Drug Des
We report the computational design and early structure–activity relationship optimisation (SAR) studies on new anticancer 4‐aryldihydropyrimidinone‐5‐carboxylate derivatives as inhibitors of heat shock protein 90. Analogue 5d emerged as a useful hit compound, combining inhibition of colony formation in breast cancer cell lines with effective Hsp90 ...
Bordoni C, Elstow TZ, Brancale A, Clarkson RWE, Westwell AD.   +4 more
europepmc   +2 more sources

DES-Promoted Synthesis of 3,4-Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies. [PDF]

Chem Biodivers
DES‐promoted synthesis and antidiabetic evaluation of 3,4‐dihydropyrimidinones and their complementation with computational studies are reported. ABSTRACT A series of 3,4‐dihydropyrimidinone (DHPM) derivatives was synthesized using a green deep eutectic solvent (DES) system composed of ZnCl2 and urea, which acted simultaneously as solvent, catalyst ...
Kumar G, Mishra S, Seboletswe P, Gcabashe N, Gummidi L, Manhas N, Makhanya T, Bhargava G, Idris A, Islam MS, Singh P.   +10 more
europepmc   +2 more sources