Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation [PDF]
ChemMedChem, Volume 20, Issue 11, June 2, 2025.Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar +10 more
wiley +2 more sources
Magnetic polymeric ionic liquid for both catalysis application and magnetic solid phase extraction approach [PDF]
Scientific ReportsIn this project, a new heterogeneous polymeric ionic liquid catalyst based on vinylimidazole, stabilized on magnetic nanoparticles )Fe3O4@Al2O3@[PBVIm]HSO4) was prepared.
Behrooz Maleki +4 more
doaj +2 more sources
Solvothermal Synthesis of Multiple Dihydropyrimidinones at a Time as Inhibitors of Eg5
Molecules, 2021 Solvothermal synthesis of multiple dihydropyrimidinones at a time has been developed in inexpensive and green bio-based solvent lactic acid without any additional catalysts or additives.
Xiao-Qiang Jiang +5 more
doaj +3 more sources
Ethyl 4-(3-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate [PDF]
Acta Crystallographica Section E, 2010 In the title compound, C14H15BrN2O3, the dihydropyrimidinone ring adopts a boat conformation. In the crystal, adjacent molecules are linked through N—H...O hydrogen bonds forming an R22(8) ring motif and generating a zigzag chain extending in ...
Rajesh G. Kalkhambkar +3 more
doaj +2 more sources
STARCH SULFURIC ACID: AN ALTERNATIVE, ECO-FRIENDLY CATALYST FOR BIGINELLI REACTION [PDF]
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2013 The one-pot multicomponent synthesis of 3,4-dihydropyrimidinone derivatives using starch sulfuric acid as an environmentally friendly biopolymer-based solid acid catalyst from aldehydes, β-keto esters and urea/ thiourea without solvent is described ...
Ramin Rezaei +3 more
doaj +2 more sources
Dihydropyrimidinones Against Multiresistant Bacteria
Frontiers in Microbiology, 2022 The increase in bacterial resistance to antimicrobials has led to high morbidity and mortality rates, posing a major public health problem, requiring the discovery of novel antimicrobial substances. The biological samples were identified as the Gram-negative bacilli Acinetobacter baumannii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae,
Marisa Castro Jara +10 more
openaire +3 more sources
SbPh3: An Efficient Catalyst for Dihydropyrimidinone and Dihydropyrimidin-5-carboxamide Synthesis Using the Biginelli Reaction [PDF]
, 2023 SbPh3: An Efficient Catalyst for Dihydropyrimidinone and Dihydropyrimidin-5-carboxamide Synthesis Using the Biginelli ...
Suman Lata (369115) +4 more
core +1 more source
Oxidative Dehydrogenation of Dihydropyrimidinones and Dihydropyrimidines [PDF]
Organic Letters, 2005 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kana, Yamamoto +2 more
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Synthesis, Biological Evaluation, 2D-QSAR, and Molecular Simulation Studies of Dihydropyrimidinone Derivatives as Alkaline Phosphatase Inhibitors [PDF]
ACS Omega, 2022 Reem Altaf +6 more
doaj +2 more sources
Results in Chemistry, 2022 An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed.
Sourav Handique, Priyanka Sharma
doaj +1 more source