Solvothermal Synthesis of Multiple Dihydropyrimidinones at a Time as Inhibitors of Eg5
Molecules, 2021 Solvothermal synthesis of multiple dihydropyrimidinones at a time has been developed in inexpensive and green bio-based solvent lactic acid without any additional catalysts or additives.
Xiao-Qiang Jiang +5 more
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Synthesis and Characterization of Some New Bis-(Dihydropyrimidinones-5-Carboxamide) by Using Ultrasonic Irradiation [PDF]
Eurasian Journal of Science and Engineering, 2018 This investigation involves synthesis of two new series of bis-dihydropyrimidinone-5-carboxamides (4 a-k) and (5 a-k) from reaction of 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetra-hydropyrimidine-5-carbonyl chloride and its derivatives (3 a, b) with different ...
Faiq H.S.Hussain , Havall O. Abdulla
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Investigating Polypharmacology through Targeting Known Human Neutrophil Elastase Inhibitors to Proteinase 3. [PDF]
J Chem Inf ModelUsing a combination of multisite λ−dynamics (MSλD) together with in vitro IC50 assays, we evaluated the polypharmacological potential of a scaffold currently in clinical trials for inhibition of human neutrophil elastase (HNE), targeting cardiopulmonary ...
Gartan P +8 more
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Human transforming growth factor β type I receptor in complex with kinase inhibitor SB505124. [PDF]
Acta Crystallogr F Struct Biol CommunThis study presents the crystal structure of transforming growth factor β type I receptor (TβR1) in complex with SB505124, highlighting the specific contacts that SB505124 makes with TβR1 and comparing these interactions with those of SB431542.The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in ...
Rodriguez Buitrago JA +2 more
europepmc +2 more sources
Editorial: Beyond borders: exploring diverse roles of heterocyclic compounds in combatting infections and cancer. [PDF]
Front ChemThis Research Topic aimed to explore the advancements and applications of heterocyclic compounds, highlighting their importance in contemporary medicinal chemistry.
Shaik AB, Bhandare RR, Rahman MM, Dua K.
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Dihydropyrimidinones Against Multiresistant Bacteria
Frontiers in Microbiology, 2022 The increase in bacterial resistance to antimicrobials has led to high morbidity and mortality rates, posing a major public health problem, requiring the discovery of novel antimicrobial substances. The biological samples were identified as the Gram-negative bacilli Acinetobacter baumannii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae,
Marisa Castro Jara +10 more
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Oxidative Dehydrogenation of Dihydropyrimidinones and Dihydropyrimidines [PDF]
Organic Letters, 2005 AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Kana, Yamamoto +2 more
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Synthesis, Biological Evaluation, 2D-QSAR, and Molecular Simulation Studies of Dihydropyrimidinone Derivatives as Alkaline Phosphatase Inhibitors [PDF]
ACS Omega, 2022 Reem Altaf +6 more
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Exploration of the chemistry and biological properties of pyrimidine as a privileged pharmacophore in therapeutics [PDF]
, 2015 The pyrimidine moiety is one of the most widespread heterocycles in biologically occurring compounds, such as nucleic acids components (uracil, thymine and cytosine) and vitamin B1.
Ajani, Olayinka O.
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Results in Chemistry, 2022 An efficient and simple procedure for synthesis of 3,4-dihydropyrimidinone or 3,4-thioxopyrimidinone maintaining eco-friendly protocol by introducing acetic acid as an organo-catalyst in presence of molecular sieves as water absorbent is disclosed.
Sourav Handique, Priyanka Sharma
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