Results 111 to 120 of about 393 (166)

Novel chalcone 2-thiopyrimidine conjugates as dual VEGFR-2/BRAF inhibitors: design, synthesis, <i>in vitro</i> cytotoxicity, and molecular docking study. [PDF]

RSC Med Chem
Abdelaziz RAI, Allam HA, El Kerdawy AM, Abo-Elfadl MT, Abbas SE, Ghannam IAY.   +5 more
europepmc   +1 more source

How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery? [PDF]

Pharmaceuticals (Basel)
Domingues L, Duarte ARC, Jesus AR.
europepmc   +1 more source

Lung perfusion imaging in nuclear medicine with ^99mTc: a comprehensive survey of radiopharmaceuticals. [PDF]

EJNMMI Radiopharm Chem
Zareian H, Mardazad M, Kiani M, Pourshafagh N, Karimi F, Ardestani MS.   +5 more
europepmc   +1 more source

Recent synthetic and medicinal perspectives of dihydropyrimidinones: A review

European Journal of Medicinal Chemistry, 2017
Dihydropyrimidines are the most important heterocyclic ring systems which play an important role in the synthesis of DNA and RNA. Synthetically they were synthesized using Multi-component reactions like Biginelli reaction and Hantzschdihydropyridine.
Ramandeep Kaur, , Manish K Gupta
exaly   +3 more sources

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Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones

Archiv Der Pharmazie, 2021
AbstractIn this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1,3‐diones. The reaction was catalyzed by lanthanum triflate and completed within 1–1.5 h, with 74–97% yield.
Ruturajsinh M Vala, Mayank G Sharma, Divyang M Patel   +2 more
exaly   +3 more sources

Chromene-dihydropyrimidinone and xanthene-dihydropyrimidinone hybrids: design, synthesis, and antibacterial and antibiofilm activities

New Journal of Chemistry, 2023
A series of chromene-dihydropyrimidinone and xanthene-dihydropyrimidinone hybrid compounds were easily synthesized through a multicomponent reaction followed by the copper-catalyzed alkyne–azide cycloaddition reaction.
Samuel J. Santos, Fernanda C. P. Rossatto, Natália S. Jardim, Daiana S. Ávila, Rodrigo Ligabue-Braun, Luiz A. M. Fontoura, Karine R. Zimmer, Dennis Russowsky   +7 more
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SAR studies on dihydropyrimidinone antibiotics

Bioorganic & Medicinal Chemistry Letters, 2011
There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing ...
Lianhong, Xu, Lijun, Zhang, Robert, Jones, Clifford, Bryant, Nina, Boddeker, Eric, Mabery, Gina, Bahador, Julia, Watson, Jeffery, Clough, Murty, Arimilli, Wendy, Gillette, Dorothy, Colagiovanni, Keyu, Wang, Craig, Gibbs, Choung U, Kim   +14 more
openaire   +2 more sources

Evaluation of Electrochemical Behavior and Antioxidant Activity of Seleno‐Dihydropyrimidinones and Chloro‐Dihydropyrimidinones

ChemistrySelect
Abstract Organic compounds with potential antioxidant activity have attracted special attention of researchers and they have been widely studied in several areas, including pharmacology and medicinal chemistry. In this context, electrochemistry through cyclic voltammetry becomes a fast and efficient tool for the ...
Neusa Fernandes DE MOURA, Romulo Faria Santos Canto, Marcelo Godoi   +2 more
exaly   +2 more sources

Recent Advance in the Pharmacology of Dihydropyrimidinone

Mini-Reviews in Medicinal Chemistry, 2012
Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and ...
J-P, Wan, Y, Pan
openaire   +2 more sources

The Biginelli Dihydropyrimidinone Synthesis

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
C. Oliver Kappe, Alexander Stadler
openaire   +1 more source