Results 91 to 100 of about 843 (203)

Multicomponent Biginelli's synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by SnCl2.2H2O

Journal of the Brazilian Chemical Society, 2004
The ability of SnCl2.2H2O as catalyst to promote the Biginelli three-component condensation reaction from a diversity of aromatic aldehydes, ethyl acetoacetate and urea or thiourea is described.
Russowsky Dennis, Lopes Fabrício A., Silva Victor S. S. da, Canto Karen F. S., D'Oca Marcelo G. Montes, Godoi Marla N.   +5 more
doaj  

Synthesis of 4-Aryl substituted 3,4-dihydropyrimidinones using silica-chloride under solvent free conditions

, 2014
: This paper describes an improved procedure for the efficient and facile synthesis of 4-aryl substituted 3, 4-dihydropyrimidinones under mild reaction conditions with excellent yields using inexpensive silica chloride under solvent free ...
Hitendra N. Karade, Manisha Sathe, M. P. Kaushik   +2 more
core  

Efficient and Green Microwave-Assisted Multicomponent Biginelli Reaction for the Synthesis of Dihydropyrimidinones Catalyzed by Heteropolyanion-Based Ionic Liquids Under Solvent-Free Conditions

, 2015
An efficient and green route for the synthesis of dihydropyrimidinones via microwave-assisted Biginelli reaction catalyzed by 3 mol% of heteropolyanion-based ionic liquids under solvent-free conditions has been reported.
Zhikai Chen (651674), Quan Wang (31224), Jian Zhou (28020), Renzhong Fu (651671), Wenchen Lai (651672), Rongxin Yuan (651676), Wen Chai (651675), Yang Yang (45629), Yongfeng Ma (651673)   +8 more
core   +1 more source

Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via Biginelli reaction promoted by bismuth(III)nitrate or PPh3 without solvent [PDF]

, 2016
3,4-Dihydropyrimidinones/thiones and their derivatives are synthesized via Biginelli routes involving an aldehyde, 1,3-dicarbonyl compound and urea or thiourea.
Moussaoui, Younes, ben Salem, Ridha, Younes Moussaoui, Ridha ben Salem, Hela Slimi, Slimi, Hela   +5 more
core   +1 more source

In vitro antifungal activity of dihydropyrimidinones/thiones against Candida albicans and Cryptococcus neoformans [PDF]

, 2017
Since the Monastrol discovery in 1999 as the first inhibitor of Eg5, functionalized dihydropyrimidinones/thiones (DHPMs) have emerged as prototypes for drug design in different targets.
Azambuja, Gabriel Oliveira de
core   +1 more source

Exploring substituted 3,4-dihydropyrimidinone and thione derivatives as anti-prostate cancer agents: Computational screening, synthesis, characterization, and in vitro efficacy assessment

Journal of Saudi Chemical Society
Despite decades of research, anticancer medication therapy is still largely constrained to prevent growth and limit the spread of tumour cells.
M.K.M. Abdul Lathiff, R. Suresh, R. Senthamarai, Sivakumar Annadurai, Richie R. Bhandare, Afzal B. Shaik   +5 more
doaj   +1 more source

Synthesis of 3,4-dihydropyrimidinones in the presence of water under solvent free conditions using conventional heating, microwave irradiation/ultrasound

, 2016
An efficient, simple, and environmentally clean synthesis of 3,4-dihydropyrimidinones in excellent yields in the presence of water without additional solvent/acid catalyst under conventional heating, microwave irradiation/ ultrasound is ...
Sain, Bir, Singhal, Sweety, Jain, Suman L, Joseph, Jomy K   +3 more
core  

Development of a Green Method for the Production of Dihydropyrimidinones Through a Biginelli Reaction

, 2014
In 2010 the United States spent 444 billion dollars treating many different cardiovascular diseases including strokes, artery diseases, high blood pressure, and other heart conditions.
Rozzo, Mike
core   +1 more source

Organocatalytic application of ionic liquids: [bmim][MeSO₄] as a recyclable organocatalyst in the multicomponent reaction for the preparation of dihydropyrimidinones and -thiones

, 2011
The organocatalytic potential of 1-butyl-3-methylimidazolium-based room-temperature ionic liquids has been investigated for the synthesis of dihydropyrimidinones and -thiones by a one-pot multicomponent reaction involving an aldehyde, a β-keto ester or β-
Roy, Sudipta Raha, Sudipta Roy, Kulin Sharma, Pradeep Jadhavar, Sharma, Kulin K., Kapileswar Seth, Chakraborti, Asit K., Jadhavar, Pradeep S., Seth, Kapileswar, Asit Chakraborti   +9 more
core   +1 more source

One-pot synthesis of dihydropyrimidinone and polyhydroquinoline derivatives with natural deep eutectic solvents (NADESs): Alternative to toxic organic solvents and environmental eco-friendly

Results in Chemistry
Natural deep eutectic solvents (NADESs) have emerged as a novel class of solvents with properties reminiscent of ionic liquids while offering additional advantages in terms of cost, environmental impact, and synthesis.
Sedigheh Ayazi Jannatabadi, Rahman Hosseinzadeh, Behrooz Maleki   +2 more
doaj   +1 more source