Results 151 to 160 of about 1,311 (206)
Novel chalcone 2-thiopyrimidine conjugates as dual VEGFR-2/BRAF inhibitors: design, synthesis, <i>in vitro</i> cytotoxicity, and molecular docking study. [PDF]
RSC Med ChemAbdelaziz RAI +5 more
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How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery? [PDF]
Pharmaceuticals (Basel)Domingues L, Duarte ARC, Jesus AR.
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Synthesis and in vitro study of antiproliferative benzyloxy dihydropyrimidinones
Archiv Der Pharmazie, 2021AbstractIn this study, we report on antiproliferative benzyloxy dihydropyrimidinones (DHPMs) produced by the Biginelli reaction of benzyloxy benzaldehyde, urea, and diverse 1,3‐diones. The reaction was catalyzed by lanthanum triflate and completed within 1–1.5 h, with 74–97% yield.
Ruturajsinh M Vala +2 more
exaly +3 more sources
ChemistrySelect
Abstract Organic compounds with potential antioxidant activity have attracted special attention of researchers and they have been widely studied in several areas, including pharmacology and medicinal chemistry. In this context, electrochemistry through cyclic voltammetry becomes a fast and efficient tool for the ...
Neusa Fernandes de Moura +2 more
exaly +2 more sources
Abstract Organic compounds with potential antioxidant activity have attracted special attention of researchers and they have been widely studied in several areas, including pharmacology and medicinal chemistry. In this context, electrochemistry through cyclic voltammetry becomes a fast and efficient tool for the ...
Neusa Fernandes de Moura +2 more
exaly +2 more sources
Efficient aerobic oxidative dehydrogenation of dihydropyrimidinones and dihydropyrimidines
Tetrahedron, 2011Abstract 4-Substituted dihydropyrimidinones and dihydropyrimidines were first efficient aerobic oxidized to the corresponding pyrimidinones and pyrimidines, respectively, in high yields by molecular oxygen in the presence of catalytic amount of N -hydroxyphthalimide (NHPI) and Co(OAc) 2 in a mild and environmental benign condition.
Yu-Wei Ren, Xiao-Yong Duan
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New Journal of Chemistry, 2023
A series of chromene-dihydropyrimidinone and xanthene-dihydropyrimidinone hybrid compounds were easily synthesized through a multicomponent reaction followed by the copper-catalyzed alkyne–azide cycloaddition reaction.
Samuel J. Santos +7 more
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A series of chromene-dihydropyrimidinone and xanthene-dihydropyrimidinone hybrid compounds were easily synthesized through a multicomponent reaction followed by the copper-catalyzed alkyne–azide cycloaddition reaction.
Samuel J. Santos +7 more
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SAR studies on dihydropyrimidinone antibiotics
Bioorganic & Medicinal Chemistry Letters, 2011There is an urgent need for the development of novel antimicrobial agents that offer effective treatment against MRSA. Using a new class of dipeptide antibiotic TAN-1057A/B as lead, we designed, synthesized and evaluated analogs of TAN-1057A/B. Several novel dihydropyrimidinone antibiotics demonstrating comparable antibiotic efficacy while possessing ...
Lianhong, Xu +14 more
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Recent Advance in the Pharmacology of Dihydropyrimidinone
Mini-Reviews in Medicinal Chemistry, 2012Dihydropyrimidinones (DHPMs) are a series of highly valuable small molecules possessing versatile pharmaceutical properties. Although the first one-pot synthesis of DHPMs had been reported more than 100 years ago, the fascinating achievement in DHPMs-based pharmacology during the past century promoted durative interests to the pharmacological and ...
J-P, Wan, Y, Pan
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