Results 151 to 160 of about 2,730,714 (181)

Alterations in Epoxyeicosatrienoic Acids Metabolism in Type 2 Diabetes Mellitus and Potential Association with Retinopathy Progression. [PDF]

Curr Med Chem
Sarı I, Ozmen E, Zor KR, Ersan S, Kucuk E, Ayan D, Abasıkeles İ.   +6 more
europepmc   +1 more source

Zinc-mediated Inhibition of Soluble Epoxide Hydrolase Promotes Pulmonary Hypertension. [PDF]

Am J Respir Crit Care Med
Simoes de Jesus D, Buffonge S, Abis G, Buccafusca R, Baliga R, Warren HR, Hobbs A, Ruppert C, Weiss A, Schermuly RT, Eaton P, Charles RL.   +11 more
europepmc   +1 more source

Reprogramming inflammation: Mechanisms and therapeutic targeting of eicosanoids and pro-resolving mediators. [PDF]

Eur J Pharmacol
Kolawole OR, Kashfi K.
europepmc   +1 more source

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Transformation of 15-Hete to 14,15-Dihydroxyeicosatrienoic Acid and 11,14,15- and 13,14,15-Trihydroxyeicosatrienoic Acid

Tetrahedron Letters, 1983
Abstract The erythro and threo 13,14-epoxides of 15(S)-HETE were transformed to 14,15-dihydroxyeicostrienoic acid (14,15-DHET) by regiospecific reduction and to a mixture of 11,14,15- and 13,14,15-trihydroxyeicosatrienoic acids (THET) by hydrolysis.
John D. Buynak, S Manna, J R Falck
exaly   +2 more sources

Determination of 14,15-Epoxyeicosatrienoic Acid and 14,15-Dihydroxyeicosatrienoic Acid by Fluoroimmunoassay

Analytical Biochemistry, 1997
A fluoroimmunoassay (FIA) for 14,15-epoxyeicosatrienoic acid (14,15-EET) and 14,15-dihydroxyeicosatrienoic acid (14,15-DHET), cytochrome P450 epoxygenase products of arachidonic acid, was developed using fluorescence polarization. 14-15-EET was hydrolyzed and analyzed as 14,15-DHET. 14,15-DHET was conjugated to thyroglobulin and a specific antibody was
John R. Falck, Kasem Nithipatikom, Rama K Bhatt   +2 more
exaly   +3 more sources

14,15-Dihydroxyeicosatrienoic Acid Activates Peroxisome Proliferator-Activated Receptor-α

American Journal of Physiology - Heart and Circulatory Physiology, 2006
Epoxyeicosatrienoic acids (EETs), lipid mediators synthesized from arachidonic acid by cytochrome P-450 epoxygenases, are converted by soluble epoxide hydrolase (SEH) to the corresponding dihydroxyeicosatrienoic acids (DHETs). Originally considered as inactive degradation products of EETs, DHETs have biological activity in some systems.
Neal L Weintraub, John R. Falck, Arthur A Spector   +2 more
exaly   +3 more sources

Development of a Semi-Automated LC/MS/MS Method for the Simultaneous Quantitation of 14,15-Epoxyeicosatrienoic Acid, 14,15-Dihydroxyeicosatrienoic Acid, Leukotoxin and Leukotoxin Diol in Human Plasma as Biomarkers of Soluble Epoxide Hydrolase Activity in Vivo

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2011
Substrates and products of soluble epoxide hydrolase (sEH) such as 14,15-epoxyeicosatrienoic acid (14,15-EET), 14,15-dihydroxyeicosatrienoic acid (14,15-DHET), leukotoxin, and leukotoxin diol are potential biomarkers for assessing sEH activity in clinical trial subjects.
Hermes Licea-Perez, James F Callahan
exaly   +3 more sources

A Sensitive LC-MS/MS Method for the Quantification of Serum Epoxyeicosatrienoic and Dihydroxyeicosatrienoic Acids in the Identification of Diabetic Kidney Disease

Analytical and Bioanalytical Chemistry
Epoxyeicosatrienoic acids (EETs) are vasoactive eicosanoids with vasodilatory, anti-inflammatory, and nephroprotective properties, and metabolized to low-bioactive dihydroxyeicosatrienoic acids (DHETs) by soluble epoxide hydrolase. Evidence from animal studies suggests that EETs may be potential biomarkers for diabetic kidney disease (DKD).
Yi, Liu, Anxian, Huang, Yongwei, Jiang, Xiaomu, Kong, Meimei, Zhao, Peng, Gao, Ming, Yang, Ziqing, Kong, Wei, Jia, Yongtong, Cao, Liang, Ma   +10 more
exaly   +3 more sources