Nature Communications, 2023 L−3,4-dihydroxyphenylalanine is an important molecule in the adhesion of mussels, and as an oxidative precursor of natural melanin, it plays an important role in living system.
Yuhe Shen +12 more
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Efficient production of salvianic acid A from l-dihydroxyphenylalanine through a tri-enzyme cascade [PDF]
Bioresources and Bioprocessing, 2023 Salvianic acid A (SAA), used for treating cardiovascular and cerebrovascular diseases, possesses several pharmacological properties. However, the current methods for the enzymatic synthesis of SAA show low efficiency.
Jiahui Yang +9 more
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Crystal structure and substrate specificity of Drosophila 3,4-dihydroxyphenylalanine decarboxylase. [PDF]
PLoS ONE, 2010 3,4-Dihydroxyphenylalanine decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase, catalyzes the decarboxylation of a number of aromatic L-amino acids.
Qian Han +4 more
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Dihydroxyphenylalanine-conjugated high molecular weight polyethylenimine for targeted delivery of Plasmid [PDF]
Scientific ReportsHigh molecular weight polyethylenimine (HMW PEI; branched 25 kDa PEI) has been widely investigated for gene delivery due to its high transfection efficiency.
Zahra Taheri +6 more
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GαolfMutation Allows Parsing the Role of cAMP-Dependent and Extracellular Signal-Regulated Kinase-Dependent Signaling in l-3,4-Dihydroxyphenylalanine-Induced Dyskinesia [PDF]
Journal of Neuroscience, 2012 Although l-3,4-dihydroxyphenylalanine (l-DOPA) remains the reference treatment of Parkinson's disease, its long-term beneficial effects are hindered by l-DOPA-induced dyskinesia (LID).
Cristina Alcacer +5 more
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l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice
Journal of Pharmacological Sciences, 2016 Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson's disease patients. We recently identified GPR143 as a candidate receptor for l-DOPA.
Suguru Ueda +3 more
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3,4-Dihydroxyphenylalanine and 5-Hydroxytryptophan as Reserpine Antagonists [PDF]
Nature, 1957 THE depletion by reserpine of storage in the body of 5-hydroxytryptamine (‘Serotonin’) and of the catechol amines is now well established1–3. In reserpinized animals the peripheral part of the adrenergic system does not function owing to lack of the transmitter2. This is presumably true also of the central part of the adrenergic system.
Arvid Carlsson +2 more
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Jurnal Veteriner, 2017 Indonesia is rich in flora potentially used for herbal medication. One of the potential herbal is koro benguk (Mucuna pruriens) beans, where in Central Java and Yogyakarta is proccessed into tempe (fermented mucuna beans) for daily human consumption ...
Tri Wahyu Pangestiningsih +2 more
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The clinical value of [18F]fluoro-dihydroxyphenylalanine positron emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumors [PDF]
Endocrine-Related Cancer, 2008 The study was set up to determine the clinical value of dihydroxyphenylalanine positron emission tomography-computed tomography ([(18)F]DOPA PET-CT) in patients with neuroendocrine tumors (NETs).
Saila Kauhanen +10 more
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The Interaction of Histamine H3 and Dopamine D1 Receptors on Hyperkinetic Alterations in Animal Models of Parkinson’s Disease [PDF]
PharmaceuticalsParkinson’s disease is associated with the loss of more than 40% of dopaminergic neurons in the substantia nigra pars compacta. One of the therapeutic options for restoring striatal dopamine levels is the administration of L-3,4-dihydroxyphenylalanine (L-
Alberto Avila-Luna +6 more
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