Results 11 to 20 of about 11,997 (297)

l-3,4-Dihydroxyphenylalanine induces ptosis through a GPR143-independent mechanism in mice [PDF]

Journal of Pharmacological Sciences, 2016
Through its conversion to dopamine by aromatic l-amino acid decarboxylase (AADC), l-3,4-dihydroxyphenylalanine (l-DOPA) replenishes depleted brain dopamine in Parkinson's disease patients. We recently identified GPR143 as a candidate receptor for l-DOPA.
Suguru Ueda, Daiki Masukawa, Motokazu Koga, Yoshio Goshima   +3 more
doaj   +2 more sources

Role of l-3,4-Dihydroxyphenylalanine in Mussel Adhesive Proteins [PDF]

, 2016
Role of l-3,4-Dihydroxyphenylalanine in Mussel Adhesive ...
Jungyeon Hwang (1413049), Timothy J. Deming (1359246), Miaoer Yu (3007038)   +2 more
core   +1 more source

Effects of Aging on Levo-Dihydroxyphenylalanine- Induced Dyskinesia in a Rat Model of Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
BackgroundIt remains unclear why patients with young-onset Parkinson’s disease more often develop levo-dihydroxyphenylalanine (L-dopa)-induced dyskinesia (LID) and have a more severe form than patients with old-onset Parkinson’s disease. Previous studies
Haruo Nishijima, Tamaki Kimura, Fumiaki Mori, Koichi Wakabayashi, Iku Kinoshita, Takashi Nakamura, Tomoya Kon, Chieko Suzuki, Masahiko Tomiyama   +8 more
doaj   +1 more source

Oxidation of peptidyl 3,4-Dihydroxyphenylalanine analogues: Implications for the biosynthesis of tunichromes and related oligopeptides [PDF]

, 1991
The o-diphenolic amino acid l-3,4-dihydroxyphenylalanine (dopa), the enamine α, β-dehydro-3,4-dihydroxyphenylalanine (Δ-dopa), and/or hydroxylated derivatives thereof, are integrated into the primary sequence of many scleroproteins and polyphenolic ...
Taylor S.W., Molinski T.F., Rzepecki L.M., Herbert Waite J.   +3 more
core   +1 more source

One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa). [PDF]

The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to means, methods and cassettes for the automated synthesis of the radiotracer 6-L-[18F]fluoro-3,4- dihydroxyphenylalanine (6-L-[18F]FDOPA).
Elsinga, Philippus Hein, Kwizera, Chantal, Farinha Antunes, Ines ; id_orcid, de Vries, Erik; id_orcid, Blok, Simon Niels, Luurtsema, Geert   +5 more
core   +10 more sources

Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice

Journal of Pharmacological Sciences, 2020
l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA.
Daiki Masukawa, Daisuke Nishizawa, Kaori Kanai, Satoshi Kitamura, Yuka Kasahara, Tatsuo Hashimoto, Ryo Takahagi, Junko Hasegawa, Kyoko Nakayama, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Kazutaka Ikeda, Yoshio Goshima   +13 more
doaj   +1 more source

Early diagnosis of focal congenital hyperinsulinism: A fluorine-18-labeled l-dihydroxyphenylalanine positron emission tomography/computed tomography study

World Journal of Nuclear Medicine, 2021
Congenital hyperinsulinism (CHI) is responsible for hyperinsulinemic hypoglycemia which needs aggressive treatment in order to prevent neurological damages.
Luca Burroni, Andrea Palucci, Giuseppina Biscontini, Valentino Cherubini   +3 more
doaj   +1 more source

3,4-Dihydroxyphenylalanine gel diffusion assay for polyphenol oxidase quantification [PDF]

, 2008
We have developed a simple, inexpensive plate assay to detect and quantify polyphenol oxidase (PPO) activity from different origins. The logarithm of enzyme activity is linearly correlated with the diameter of the dark, L-3,4-dihydroxyphenylalanine (L ...
LANTE, ANNA, LOMOLINO, GIOVANNA, ZOCCA F
core   +1 more source

Genetic incorporation ofl-dihydroxyphenylalanine (DOPA) biosynthesized by a tyrosine phenol-lyase [PDF]

, 2018
l-Dihydroxyphenylalanine (DOPA) was biosynthesized by a tyrosine-phenol lyase from catechol, pyruvate, and ammonia inEscherichia coli, and the biosynthesized amino acid was directly incorporated into proteins.
Hyun Soo Lee, S Kim, S C Kim, Sanggil Kim, H S Lee, Bong Hyun Sung, Sun Chang Kim   +6 more
core   +1 more source

Effect of Selective Serotonin Reuptake Inhibitors via 5-HT1A Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model

Journal of Pharmacological Sciences, 2012
l-Dihydroxyphenylalanine (l-DOPA) is considered the gold standard for the treatment of Parkinson’s disease (PD). However, long-term administration of l-DOPA can induce abnormal side effects.
Masatoshi Inden, Mari Abe, Hideaki Minamino, Kazuyuki Takata, Kanji Yoshimoto, Ikuo Tooyama, Yoshihisa Kitamura   +6 more
doaj   +1 more source