Results 11 to 20 of about 25,647 (343)

Involvement of the L-DOPA receptor GPR143 in acute and chronic actions of methylphenidate

Journal of Pharmacological Sciences, 2023
Methylphenidate (MPH) and methamphetamine (METH) are the current treatments of choice for attention deficit/hyperactivity disorder. We previously reported that METH induces the release of dopamine (DA) and of the neurotransmitter candidate L-3,4 ...
Hiraku Uchimura, Kaori Kanai, Masami Arai, Miyu Inoue, Akitoyo Hishimoto, Daiki Masukawa, Yoshio Goshima   +6 more
doaj   +1 more source

The aromatic amino acid hydroxylase genes AAH1 and AAH2 in Toxoplasma gondii contribute to transmission in the cat [PDF]

, 2017
The Toxoplasma gondii genome contains two aromatic amino acid hydroxylase genes, AAH1 and AAH2 encode proteins that produce L-DOPA, which can serve as a precursor of catecholamine neurotransmitters.
Dubey, Jitender P, Sibley, L. David, Verma, Shiv K, Wang, Zi T   +3 more
core   +6 more sources

Novel Strecker degradation products of tyrosine and dihydroxyphenylalanine

Czech Journal of Food Sciences, 2001
Tyrosine was oxidised with either potassium peroxodisulphate or glyoxal. Volatile reaction products were isolated and analysed by GC/FID and GC/MS, derivatised with diazomethane and analysed by the same methods.
J. Adamiec, K. Cejpek, J. Rössner, J. Velíšek   +3 more
doaj   +1 more source

Biomedical and Clinical Importance of Mussel-Inspired Polymers and Materials

Marine Drugs, 2015
The substance secreted by mussels, also known as nature’s glue, is a type of liquid protein that hardens rapidly into a solid water-resistant adhesive material.
Nagendra Kumar Kaushik, Neha Kaushik, Sunil Pardeshi, Jai Gopal Sharma, Seung Hyun Lee, Eun Ha Choi   +5 more
doaj   +1 more source

Dopamine D 4 Receptor-Deficient Mice Display Cortical Hyperexcitability [PDF]

, 2001
The dopamine D(4) receptor (D(4)R) is predominantly expressed in the frontal cortex (FC), a brain region that receives dense input from midbrain dopamine (DA) neurons and is associated with cognitive and emotional processes.
Ariano, Marjorie A., Bunzow, James R., Cepeda, Carlos, Falzone, Tomas Luis, Flores Hernandez, Jorge, Grandy, David K., Hurst, Raymond S., Kozell, Laura B., Levine, Michael S., Low, Malcolm J., Meshul, Charles K., Rubinstein, Marcelo   +11 more
core   +1 more source

Effects of Aging on Levo-Dihydroxyphenylalanine- Induced Dyskinesia in a Rat Model of Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
BackgroundIt remains unclear why patients with young-onset Parkinson’s disease more often develop levo-dihydroxyphenylalanine (L-dopa)-induced dyskinesia (LID) and have a more severe form than patients with old-onset Parkinson’s disease. Previous studies
Haruo Nishijima, Tamaki Kimura, Fumiaki Mori, Koichi Wakabayashi, Iku Kinoshita, Takashi Nakamura, Tomoya Kon, Chieko Suzuki, Masahiko Tomiyama   +8 more
doaj   +1 more source

Magnetic resonance imaging-guided phase 1 trial of putaminal AADC gene therapy for Parkinson's disease. [PDF]

, 2019
ObjectiveTo understand the safety, putaminal coverage, and enzyme expression of adeno-associated viral vector serotype-2 encoding the complementary DNA for the enzyme, aromatic L-amino acid decarboxylase (VY-AADC01), delivered using novel intraoperative ...
Bankiewicz, Krystof S, Boot, Brendon, Christine, Chadwick W, Kells, Adrian P, Larson, Paul S, Martin, Alastair J, Nutt, John, Ravina, Bernard, Richardson, R Mark, Thompson, Marin E, Van Laar, Amber D   +10 more
core   +1 more source

Genetic associations of single nucleotide polymorphisms in the l-DOPA receptor (GPR143) gene with severity of nicotine dependence in Japanese individuals, and attenuation of nicotine reinforcement in Gpr143 gene-deficient mice

Journal of Pharmacological Sciences, 2020
l-3,4-dihydroxyphenylalanine (l-DOPA) is a candidate neurotransmitter. l-DOPA is released by nicotine through nicotinic receptors. Recently, G-protein coupled receptor GPR143, was identified as a receptor for l-DOPA.
Daiki Masukawa, Daisuke Nishizawa, Kaori Kanai, Satoshi Kitamura, Yuka Kasahara, Tatsuo Hashimoto, Ryo Takahagi, Junko Hasegawa, Kyoko Nakayama, Naomi Sato, Fumihiko Tanioka, Haruhiko Sugimura, Kazutaka Ikeda, Yoshio Goshima   +13 more
doaj   +1 more source

Early diagnosis of focal congenital hyperinsulinism: A fluorine-18-labeled l-dihydroxyphenylalanine positron emission tomography/computed tomography study

World Journal of Nuclear Medicine, 2021
Congenital hyperinsulinism (CHI) is responsible for hyperinsulinemic hypoglycemia which needs aggressive treatment in order to prevent neurological damages.
Luca Burroni, Andrea Palucci, Giuseppina Biscontini, Valentino Cherubini   +3 more
doaj   +1 more source

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Conversion of ribonucleotides to the 2′-deoxyribonucleotides required for DNA biosynthesis is catalyzed by ribonucleotide reductases (RNRs) via a free-radical mechanism.
Elizabeth J. Blaesi, G. Palowitch, K. Hu, Amelia J. Kim, Hannah R. Rose, R. Alapati, Marshall G. Lougee, H. Kim, Alexander T. Taguchi, K. Tan, Tatiana N. Laremore, R. Griffin, C. Krebs, Megan L. Matthews, Alexey Silakov, J. Bollinger, Benjamin D. Allen, A. Boal   +17 more
semanticscholar   +1 more source